Adipose tissue-derived mesenchymal stem cells increase skin allograft survival and inhibit Th-17 immune response.

Adipose tissue-derived mesenchymal stem cells (ADSC) exhibit immunosuppressive capabilities both in vitro and in vivo. Their use for therapy in the transplant field is attractive as they could render the use of immunosuppressive drugs unnecessary. The aim of this study was to investigate the effect...

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Autores principales:	Rafael Assumpção Larocca, Pedro Manoel Moraes-Vieira, Enio José Bassi, Patrícia Semedo, Danilo Candido de Almeida, Marina Burgos da Silva, Thomas Thornley, Alvaro Pacheco-Silva, Niels Olsen Saraiva Câmara
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/caa5f0b345824fa79196e25c41b582c0
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spelling	oai:doaj.org-article:caa5f0b345824fa79196e25c41b582c02021-11-18T08:52:24ZAdipose tissue-derived mesenchymal stem cells increase skin allograft survival and inhibit Th-17 immune response.1932-620310.1371/journal.pone.0076396https://doaj.org/article/caa5f0b345824fa79196e25c41b582c02013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24124557/?tool=EBIhttps://doaj.org/toc/1932-6203Adipose tissue-derived mesenchymal stem cells (ADSC) exhibit immunosuppressive capabilities both in vitro and in vivo. Their use for therapy in the transplant field is attractive as they could render the use of immunosuppressive drugs unnecessary. The aim of this study was to investigate the effect of ADSC therapy on prolonging skin allograft survival. Animals that were treated with a single injection of donor allogeneic ADSC one day after transplantation showed an increase in donor skin graft survival by approximately one week. This improvement was associated with preserved histological morphology, an expansion of CD4(+) regulatory T cells (Treg) in draining lymph nodes, as well as heightened IL-10 expression and down-regulated IL-17 expression. In vitro, ADSC inhibit naïve CD4(+) T cell proliferation and constrain Th-1 and Th-17 polarization. In summary, infusion of ADSC one day post-transplantation dramatically increases skin allograft survival by inhibiting the Th-17 pathogenic immune response and enhancing the protective Treg immune response. Finally, these data suggest that ADSC therapy will open new opportunities for promoting drug-free allograft survival in clinical transplantation.Rafael Assumpção LaroccaPedro Manoel Moraes-VieiraEnio José BassiPatrícia SemedoDanilo Candido de AlmeidaMarina Burgos da SilvaThomas ThornleyAlvaro Pacheco-SilvaNiels Olsen Saraiva CâmaraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 10, p e76396 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rafael Assumpção Larocca Pedro Manoel Moraes-Vieira Enio José Bassi Patrícia Semedo Danilo Candido de Almeida Marina Burgos da Silva Thomas Thornley Alvaro Pacheco-Silva Niels Olsen Saraiva Câmara Adipose tissue-derived mesenchymal stem cells increase skin allograft survival and inhibit Th-17 immune response.
description	Adipose tissue-derived mesenchymal stem cells (ADSC) exhibit immunosuppressive capabilities both in vitro and in vivo. Their use for therapy in the transplant field is attractive as they could render the use of immunosuppressive drugs unnecessary. The aim of this study was to investigate the effect of ADSC therapy on prolonging skin allograft survival. Animals that were treated with a single injection of donor allogeneic ADSC one day after transplantation showed an increase in donor skin graft survival by approximately one week. This improvement was associated with preserved histological morphology, an expansion of CD4(+) regulatory T cells (Treg) in draining lymph nodes, as well as heightened IL-10 expression and down-regulated IL-17 expression. In vitro, ADSC inhibit naïve CD4(+) T cell proliferation and constrain Th-1 and Th-17 polarization. In summary, infusion of ADSC one day post-transplantation dramatically increases skin allograft survival by inhibiting the Th-17 pathogenic immune response and enhancing the protective Treg immune response. Finally, these data suggest that ADSC therapy will open new opportunities for promoting drug-free allograft survival in clinical transplantation.
format	article
author	Rafael Assumpção Larocca Pedro Manoel Moraes-Vieira Enio José Bassi Patrícia Semedo Danilo Candido de Almeida Marina Burgos da Silva Thomas Thornley Alvaro Pacheco-Silva Niels Olsen Saraiva Câmara
author_facet	Rafael Assumpção Larocca Pedro Manoel Moraes-Vieira Enio José Bassi Patrícia Semedo Danilo Candido de Almeida Marina Burgos da Silva Thomas Thornley Alvaro Pacheco-Silva Niels Olsen Saraiva Câmara
author_sort	Rafael Assumpção Larocca
title	Adipose tissue-derived mesenchymal stem cells increase skin allograft survival and inhibit Th-17 immune response.
title_short	Adipose tissue-derived mesenchymal stem cells increase skin allograft survival and inhibit Th-17 immune response.
title_full	Adipose tissue-derived mesenchymal stem cells increase skin allograft survival and inhibit Th-17 immune response.
title_fullStr	Adipose tissue-derived mesenchymal stem cells increase skin allograft survival and inhibit Th-17 immune response.
title_full_unstemmed	Adipose tissue-derived mesenchymal stem cells increase skin allograft survival and inhibit Th-17 immune response.
title_sort	adipose tissue-derived mesenchymal stem cells increase skin allograft survival and inhibit th-17 immune response.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/caa5f0b345824fa79196e25c41b582c0
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Adipose tissue-derived mesenchymal stem cells increase skin allograft survival and inhibit Th-17 immune response.

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