Cognitive declines precede and predict functional declines in aging and Alzheimer's disease.

<h4>Objective</h4>To investigate the temporal ordering of cognitive and functional declines separately in older adults with or without Alzheimer's disease (AD).<h4>Design and setting</h4>A community-based longitudinal study of aging and dementia in Northern Manhattan (Wa...

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Autores principales:	Laura B Zahodne, Jennifer J Manly, Anna MacKay-Brandt, Yaakov Stern
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/caab39ac28e14a99bc9f0b179d0f8929
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spelling	oai:doaj.org-article:caab39ac28e14a99bc9f0b179d0f89292021-11-18T08:57:19ZCognitive declines precede and predict functional declines in aging and Alzheimer's disease.1932-620310.1371/journal.pone.0073645https://doaj.org/article/caab39ac28e14a99bc9f0b179d0f89292013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24023894/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>To investigate the temporal ordering of cognitive and functional declines separately in older adults with or without Alzheimer's disease (AD).<h4>Design and setting</h4>A community-based longitudinal study of aging and dementia in Northern Manhattan (Washington Heights/Hamilton Heights Inwood Columbia Aging Project) and a multicenter, clinic-based longitudinal study of prevalent AD at Columbia University Medical Center, Johns Hopkins School of Medicine, Massachusetts General Hospital, and the Hôpital de la Salpêtrière in Paris, France (the Predictors Study).<h4>Participants</h4>3,443 initially non-demented older adults (612 with eventual incident dementia) and 517 patients with AD.<h4>Main outcome measures</h4>Cognitive measures included the modified Mini-Mental State Exam and composite scores of memory and language derived from a standardized neuropsychological battery. Function was measured with the Blessed Dementia Rating Scale, completed by the participant (in the sample of non-demented older adults) or an informant (in the sample of prevalent AD patients). Data were analyzed with autoregressive cross-lagged panel analysis.<h4>Results</h4>Cognitive scores more consistently predicted subsequent functional abilities than vice versa in non-demented older adults, participants with eventual incident dementia, and patients with prevalent AD.<h4>Conclusions</h4>Cognitive declines appear to precede and cause functional declines prior to and following dementia diagnosis. Standardized neuropsychological tests are valid predictors of later functional changes in both non-demented and demented older adults.Laura B ZahodneJennifer J ManlyAnna MacKay-BrandtYaakov SternPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e73645 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Laura B Zahodne Jennifer J Manly Anna MacKay-Brandt Yaakov Stern Cognitive declines precede and predict functional declines in aging and Alzheimer's disease.
description	<h4>Objective</h4>To investigate the temporal ordering of cognitive and functional declines separately in older adults with or without Alzheimer's disease (AD).<h4>Design and setting</h4>A community-based longitudinal study of aging and dementia in Northern Manhattan (Washington Heights/Hamilton Heights Inwood Columbia Aging Project) and a multicenter, clinic-based longitudinal study of prevalent AD at Columbia University Medical Center, Johns Hopkins School of Medicine, Massachusetts General Hospital, and the Hôpital de la Salpêtrière in Paris, France (the Predictors Study).<h4>Participants</h4>3,443 initially non-demented older adults (612 with eventual incident dementia) and 517 patients with AD.<h4>Main outcome measures</h4>Cognitive measures included the modified Mini-Mental State Exam and composite scores of memory and language derived from a standardized neuropsychological battery. Function was measured with the Blessed Dementia Rating Scale, completed by the participant (in the sample of non-demented older adults) or an informant (in the sample of prevalent AD patients). Data were analyzed with autoregressive cross-lagged panel analysis.<h4>Results</h4>Cognitive scores more consistently predicted subsequent functional abilities than vice versa in non-demented older adults, participants with eventual incident dementia, and patients with prevalent AD.<h4>Conclusions</h4>Cognitive declines appear to precede and cause functional declines prior to and following dementia diagnosis. Standardized neuropsychological tests are valid predictors of later functional changes in both non-demented and demented older adults.
format	article
author	Laura B Zahodne Jennifer J Manly Anna MacKay-Brandt Yaakov Stern
author_facet	Laura B Zahodne Jennifer J Manly Anna MacKay-Brandt Yaakov Stern
author_sort	Laura B Zahodne
title	Cognitive declines precede and predict functional declines in aging and Alzheimer's disease.
title_short	Cognitive declines precede and predict functional declines in aging and Alzheimer's disease.
title_full	Cognitive declines precede and predict functional declines in aging and Alzheimer's disease.
title_fullStr	Cognitive declines precede and predict functional declines in aging and Alzheimer's disease.
title_full_unstemmed	Cognitive declines precede and predict functional declines in aging and Alzheimer's disease.
title_sort	cognitive declines precede and predict functional declines in aging and alzheimer's disease.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/caab39ac28e14a99bc9f0b179d0f8929
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Cognitive declines precede and predict functional declines in aging and Alzheimer's disease.

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