POTENTIAL OF ANTHOCYANIN BASED POLY (METHYL METHACRYLATE) NANOPARTICLES SPECIFIC ACTIVATED MICROGLIA IN MANAGEMENT INFLAMMATORY PAIN ON HERNIATED NUCLEUS PULPOSUS: A LITERATURE REVIEW

Pain is an unpleasant sensory and emotional experience that can affect the quality of life and leads to decreased productivity in patients. Low back pain (LBP) is one of the significant causes of disability worldwide with lifelong incidence. The purpose of this literature review describes the potent...

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Autores principales:	I Putu Eka Widyadharma, Agung Bagus Sista Satyarsa, Feliani Sanjaya, Ni Made Gitari, I Wayan Niryana, Thomas Eko Purwata, I Made Jawi, Dewa Ngurah Suprapta, AA Raka Sudewi
Formato:	article
Lenguaje:	EN ID
Publicado:	University of Brawijaya 2021
Materias:	anti-nociceptive; anthocyanin; hernia nucleus pulposus; and poly (methyl methacrylate) nanoparticles Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/caacd6a670764b8799aeef68f7505dd1
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spelling	oai:doaj.org-article:caacd6a670764b8799aeef68f7505dd12021-11-23T03:38:23ZPOTENTIAL OF ANTHOCYANIN BASED POLY (METHYL METHACRYLATE) NANOPARTICLES SPECIFIC ACTIVATED MICROGLIA IN MANAGEMENT INFLAMMATORY PAIN ON HERNIATED NUCLEUS PULPOSUS: A LITERATURE REVIEW10.21776/ub.mnj.2021.007.01.92407-67242442-5001https://doaj.org/article/caacd6a670764b8799aeef68f7505dd12021-01-01T00:00:00Zhttps://mnj.ub.ac.id/index.php/mnj/article/view/428https://doaj.org/toc/2407-6724https://doaj.org/toc/2442-5001Pain is an unpleasant sensory and emotional experience that can affect the quality of life and leads to decreased productivity in patients. Low back pain (LBP) is one of the significant causes of disability worldwide with lifelong incidence. The purpose of this literature review describes the potential of anthocyanin-based Poly (Methyl Methacrylate) (PMMA) nanoparticles as the management of inflammatory pain in the Hernia Nucleus Pulposus (HNP ). The method used is a literature study by entering the keyword. Of the 77 journals reviewed, 47 journals were found by the topic and used as a reference for this work. The anthocyanin-based PMMA nanoparticles act as anti-nociceptors by inhibiting microglia that produce inflammatory mediators in HNP. Poly (Methyl Methacrylate) nanoparticles have specific targets in microglia. Anthocyanins have the effect of inhibiting inflammatory pain through many destinations. Anthocyanin inhibits the synthesis of nitric oxide (NO ) and prostaglandin E2 (PGE 2) and inhibits the activation of p38 MAPK and NF-kB pathways that express TNF-α and IL-1β genes as anti-nociceptive. The anthocyanin-based PMMA nanoparticles have potential as a novel therapy for inflammatory pain in HNP. There has been no research between these modalities. Therefore, further research is needed to find out the exact potential of anthocyanin-based PMMA nanoparticles.I Putu Eka WidyadharmaAgung Bagus Sista SatyarsaFeliani SanjayaNi Made GitariI Wayan NiryanaThomas Eko PurwataI Made JawiDewa Ngurah SupraptaAA Raka SudewiUniversity of Brawijayaarticleanti-nociceptive; anthocyanin; hernia nucleus pulposus; and poly (methyl methacrylate) nanoparticlesMedicineRNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENIDMalang Neurology Journal, Vol 7, Iss 1, Pp 40-47 (2021)
institution	DOAJ
collection	DOAJ
language	EN ID
topic	anti-nociceptive; anthocyanin; hernia nucleus pulposus; and poly (methyl methacrylate) nanoparticles Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	anti-nociceptive; anthocyanin; hernia nucleus pulposus; and poly (methyl methacrylate) nanoparticles Medicine R Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 I Putu Eka Widyadharma Agung Bagus Sista Satyarsa Feliani Sanjaya Ni Made Gitari I Wayan Niryana Thomas Eko Purwata I Made Jawi Dewa Ngurah Suprapta AA Raka Sudewi POTENTIAL OF ANTHOCYANIN BASED POLY (METHYL METHACRYLATE) NANOPARTICLES SPECIFIC ACTIVATED MICROGLIA IN MANAGEMENT INFLAMMATORY PAIN ON HERNIATED NUCLEUS PULPOSUS: A LITERATURE REVIEW
description	Pain is an unpleasant sensory and emotional experience that can affect the quality of life and leads to decreased productivity in patients. Low back pain (LBP) is one of the significant causes of disability worldwide with lifelong incidence. The purpose of this literature review describes the potential of anthocyanin-based Poly (Methyl Methacrylate) (PMMA) nanoparticles as the management of inflammatory pain in the Hernia Nucleus Pulposus (HNP ). The method used is a literature study by entering the keyword. Of the 77 journals reviewed, 47 journals were found by the topic and used as a reference for this work. The anthocyanin-based PMMA nanoparticles act as anti-nociceptors by inhibiting microglia that produce inflammatory mediators in HNP. Poly (Methyl Methacrylate) nanoparticles have specific targets in microglia. Anthocyanins have the effect of inhibiting inflammatory pain through many destinations. Anthocyanin inhibits the synthesis of nitric oxide (NO ) and prostaglandin E2 (PGE 2) and inhibits the activation of p38 MAPK and NF-kB pathways that express TNF-α and IL-1β genes as anti-nociceptive. The anthocyanin-based PMMA nanoparticles have potential as a novel therapy for inflammatory pain in HNP. There has been no research between these modalities. Therefore, further research is needed to find out the exact potential of anthocyanin-based PMMA nanoparticles.
format	article
author	I Putu Eka Widyadharma Agung Bagus Sista Satyarsa Feliani Sanjaya Ni Made Gitari I Wayan Niryana Thomas Eko Purwata I Made Jawi Dewa Ngurah Suprapta AA Raka Sudewi
author_facet	I Putu Eka Widyadharma Agung Bagus Sista Satyarsa Feliani Sanjaya Ni Made Gitari I Wayan Niryana Thomas Eko Purwata I Made Jawi Dewa Ngurah Suprapta AA Raka Sudewi
author_sort	I Putu Eka Widyadharma
title	POTENTIAL OF ANTHOCYANIN BASED POLY (METHYL METHACRYLATE) NANOPARTICLES SPECIFIC ACTIVATED MICROGLIA IN MANAGEMENT INFLAMMATORY PAIN ON HERNIATED NUCLEUS PULPOSUS: A LITERATURE REVIEW
title_short	POTENTIAL OF ANTHOCYANIN BASED POLY (METHYL METHACRYLATE) NANOPARTICLES SPECIFIC ACTIVATED MICROGLIA IN MANAGEMENT INFLAMMATORY PAIN ON HERNIATED NUCLEUS PULPOSUS: A LITERATURE REVIEW
title_full	POTENTIAL OF ANTHOCYANIN BASED POLY (METHYL METHACRYLATE) NANOPARTICLES SPECIFIC ACTIVATED MICROGLIA IN MANAGEMENT INFLAMMATORY PAIN ON HERNIATED NUCLEUS PULPOSUS: A LITERATURE REVIEW
title_fullStr	POTENTIAL OF ANTHOCYANIN BASED POLY (METHYL METHACRYLATE) NANOPARTICLES SPECIFIC ACTIVATED MICROGLIA IN MANAGEMENT INFLAMMATORY PAIN ON HERNIATED NUCLEUS PULPOSUS: A LITERATURE REVIEW
title_full_unstemmed	POTENTIAL OF ANTHOCYANIN BASED POLY (METHYL METHACRYLATE) NANOPARTICLES SPECIFIC ACTIVATED MICROGLIA IN MANAGEMENT INFLAMMATORY PAIN ON HERNIATED NUCLEUS PULPOSUS: A LITERATURE REVIEW
title_sort	potential of anthocyanin based poly (methyl methacrylate) nanoparticles specific activated microglia in management inflammatory pain on herniated nucleus pulposus: a literature review
publisher	University of Brawijaya
publishDate	2021
url	https://doaj.org/article/caacd6a670764b8799aeef68f7505dd1
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POTENTIAL OF ANTHOCYANIN BASED POLY (METHYL METHACRYLATE) NANOPARTICLES SPECIFIC ACTIVATED MICROGLIA IN MANAGEMENT INFLAMMATORY PAIN ON HERNIATED NUCLEUS PULPOSUS: A LITERATURE REVIEW

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