The efficacy of biliary and serum macrophage inhibitory cytokine-1 for diagnosing biliary tract cancer

Abstract The serum macrophage inhibitory cytokine-1 (MIC-1) levels are elevated in some inflammatory conditions and cancers. We thus compared the levels of biliary and serum MIC-1 and conventional tumour markers between 23 biliary tract cancer (BTC) patients (malignant group) and 29 benign biliary d...

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Autores principales:	Mitsuru Sugimoto, Tadayuki Takagi, Naoki Konno, Rei Suzuki, Hiroyuki Asama, Ko Watanabe, Jun Nakamura, Yuichi Waragai, Hitomi Kikuchi, Mika Takasumi, Yuki Sato, Takuto Hikichi, Hiromasa Ohira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/caae148b3e58493c98e22ba3da3337bd
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spelling	oai:doaj.org-article:caae148b3e58493c98e22ba3da3337bd2021-12-02T16:07:44ZThe efficacy of biliary and serum macrophage inhibitory cytokine-1 for diagnosing biliary tract cancer10.1038/s41598-017-09740-x2045-2322https://doaj.org/article/caae148b3e58493c98e22ba3da3337bd2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09740-xhttps://doaj.org/toc/2045-2322Abstract The serum macrophage inhibitory cytokine-1 (MIC-1) levels are elevated in some inflammatory conditions and cancers. We thus compared the levels of biliary and serum MIC-1 and conventional tumour markers between 23 biliary tract cancer (BTC) patients (malignant group) and 29 benign biliary disease patients (benign group) and found that all markers were significantly elevated in the malignant group. The levels of two markers were higher in early BTC (Stage I/II, n = 15) than in the benign group: biliary MIC-1 [12 (0–2153) vs. 678 (0–4429) pg/ml, P < 0.01] and serum CA19–9 [13 (2–15,682) vs. 45.1 (2–10,478) U/ml, P = 0.02]. A receiver operating characteristic curve analysis revealed that the area under the curve for biliary MIC-1 was greater than that for serum CA19-9 (0.77 vs. 0.73). The cut-off value for biliary MIC-1 in diagnosing early BTC was 581.6 pg/ml, and this value yielded a sensitivity, specificity and accuracy of 71.4%, 82.8%, and 79.1%, respectively. The sensitivity of biliary MIC-1 for diagnosing early BTC was superior to that of biliary cytology (71.4% vs. 8.33%, P < 0.01), and the combination of serum MIC-1 with CA19-9 (cut-off value = 4021.2 pg/ml, 42.4 U/ml) was useful for screening BTC (sensitivity = 82.6%, specificity = 72.4%). In conclusion, biliary MIC-1 can effectively diagnose early BTC.Mitsuru SugimotoTadayuki TakagiNaoki KonnoRei SuzukiHiroyuki AsamaKo WatanabeJun NakamuraYuichi WaragaiHitomi KikuchiMika TakasumiYuki SatoTakuto HikichiHiromasa OhiraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mitsuru Sugimoto Tadayuki Takagi Naoki Konno Rei Suzuki Hiroyuki Asama Ko Watanabe Jun Nakamura Yuichi Waragai Hitomi Kikuchi Mika Takasumi Yuki Sato Takuto Hikichi Hiromasa Ohira The efficacy of biliary and serum macrophage inhibitory cytokine-1 for diagnosing biliary tract cancer
description	Abstract The serum macrophage inhibitory cytokine-1 (MIC-1) levels are elevated in some inflammatory conditions and cancers. We thus compared the levels of biliary and serum MIC-1 and conventional tumour markers between 23 biliary tract cancer (BTC) patients (malignant group) and 29 benign biliary disease patients (benign group) and found that all markers were significantly elevated in the malignant group. The levels of two markers were higher in early BTC (Stage I/II, n = 15) than in the benign group: biliary MIC-1 [12 (0–2153) vs. 678 (0–4429) pg/ml, P < 0.01] and serum CA19–9 [13 (2–15,682) vs. 45.1 (2–10,478) U/ml, P = 0.02]. A receiver operating characteristic curve analysis revealed that the area under the curve for biliary MIC-1 was greater than that for serum CA19-9 (0.77 vs. 0.73). The cut-off value for biliary MIC-1 in diagnosing early BTC was 581.6 pg/ml, and this value yielded a sensitivity, specificity and accuracy of 71.4%, 82.8%, and 79.1%, respectively. The sensitivity of biliary MIC-1 for diagnosing early BTC was superior to that of biliary cytology (71.4% vs. 8.33%, P < 0.01), and the combination of serum MIC-1 with CA19-9 (cut-off value = 4021.2 pg/ml, 42.4 U/ml) was useful for screening BTC (sensitivity = 82.6%, specificity = 72.4%). In conclusion, biliary MIC-1 can effectively diagnose early BTC.
format	article
author	Mitsuru Sugimoto Tadayuki Takagi Naoki Konno Rei Suzuki Hiroyuki Asama Ko Watanabe Jun Nakamura Yuichi Waragai Hitomi Kikuchi Mika Takasumi Yuki Sato Takuto Hikichi Hiromasa Ohira
author_facet	Mitsuru Sugimoto Tadayuki Takagi Naoki Konno Rei Suzuki Hiroyuki Asama Ko Watanabe Jun Nakamura Yuichi Waragai Hitomi Kikuchi Mika Takasumi Yuki Sato Takuto Hikichi Hiromasa Ohira
author_sort	Mitsuru Sugimoto
title	The efficacy of biliary and serum macrophage inhibitory cytokine-1 for diagnosing biliary tract cancer
title_short	The efficacy of biliary and serum macrophage inhibitory cytokine-1 for diagnosing biliary tract cancer
title_full	The efficacy of biliary and serum macrophage inhibitory cytokine-1 for diagnosing biliary tract cancer
title_fullStr	The efficacy of biliary and serum macrophage inhibitory cytokine-1 for diagnosing biliary tract cancer
title_full_unstemmed	The efficacy of biliary and serum macrophage inhibitory cytokine-1 for diagnosing biliary tract cancer
title_sort	efficacy of biliary and serum macrophage inhibitory cytokine-1 for diagnosing biliary tract cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/caae148b3e58493c98e22ba3da3337bd
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The efficacy of biliary and serum macrophage inhibitory cytokine-1 for diagnosing biliary tract cancer

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