Genetic predispositions moderate the effectiveness of tobacco excise taxes

<h4>Background</h4> Tobacco consumption is one of the leading causes of preventable death. In this study, we analyze whether someone’s genetic predisposition to smoking moderates the response to tobacco excise taxes. <h4>Methods</h4> We interact polygenic scores for smoking b...

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Autores principales:	Eric A. W. Slob, Cornelius A. Rietveld
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/caaf36e918c440699bdbc2059f4aaeb0
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spelling	oai:doaj.org-article:caaf36e918c440699bdbc2059f4aaeb02021-11-11T08:14:53ZGenetic predispositions moderate the effectiveness of tobacco excise taxes1932-6203https://doaj.org/article/caaf36e918c440699bdbc2059f4aaeb02021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8570524/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4> Tobacco consumption is one of the leading causes of preventable death. In this study, we analyze whether someone’s genetic predisposition to smoking moderates the response to tobacco excise taxes. <h4>Methods</h4> We interact polygenic scores for smoking behavior with state-level tobacco excise taxes in longitudinal data (1992-2016) from the US Health and Retirement Study (N = 12,058). <h4>Results</h4> Someone’s genetic propensity to smoking moderates the effect of tobacco excise taxes on smoking behavior along the extensive margin (smoking vs. not smoking) and the intensive margin (the amount of tobacco consumed). In our analysis sample, we do not find a significant gene-environment interaction effect on smoking cessation. <h4>Conclusions</h4> When tobacco excise taxes are relatively high, those with a high genetic predisposition to smoking are less likely (i) to smoke, and (ii) to smoke heavily. While tobacco excise taxes have been effective in reducing smoking, the gene-environment interaction effects we observe in our sample suggest that policy makers could benefit from taking into account the moderating role of genes in the design of future tobacco control policies.Eric A. W. SlobCornelius A. RietveldPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eric A. W. Slob Cornelius A. Rietveld Genetic predispositions moderate the effectiveness of tobacco excise taxes
description	<h4>Background</h4> Tobacco consumption is one of the leading causes of preventable death. In this study, we analyze whether someone’s genetic predisposition to smoking moderates the response to tobacco excise taxes. <h4>Methods</h4> We interact polygenic scores for smoking behavior with state-level tobacco excise taxes in longitudinal data (1992-2016) from the US Health and Retirement Study (N = 12,058). <h4>Results</h4> Someone’s genetic propensity to smoking moderates the effect of tobacco excise taxes on smoking behavior along the extensive margin (smoking vs. not smoking) and the intensive margin (the amount of tobacco consumed). In our analysis sample, we do not find a significant gene-environment interaction effect on smoking cessation. <h4>Conclusions</h4> When tobacco excise taxes are relatively high, those with a high genetic predisposition to smoking are less likely (i) to smoke, and (ii) to smoke heavily. While tobacco excise taxes have been effective in reducing smoking, the gene-environment interaction effects we observe in our sample suggest that policy makers could benefit from taking into account the moderating role of genes in the design of future tobacco control policies.
format	article
author	Eric A. W. Slob Cornelius A. Rietveld
author_facet	Eric A. W. Slob Cornelius A. Rietveld
author_sort	Eric A. W. Slob
title	Genetic predispositions moderate the effectiveness of tobacco excise taxes
title_short	Genetic predispositions moderate the effectiveness of tobacco excise taxes
title_full	Genetic predispositions moderate the effectiveness of tobacco excise taxes
title_fullStr	Genetic predispositions moderate the effectiveness of tobacco excise taxes
title_full_unstemmed	Genetic predispositions moderate the effectiveness of tobacco excise taxes
title_sort	genetic predispositions moderate the effectiveness of tobacco excise taxes
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/caaf36e918c440699bdbc2059f4aaeb0
work_keys_str_mv	AT ericawslob geneticpredispositionsmoderatetheeffectivenessoftobaccoexcisetaxes AT corneliusarietveld geneticpredispositionsmoderatetheeffectivenessoftobaccoexcisetaxes
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Genetic predispositions moderate the effectiveness of tobacco excise taxes

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