Nephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic Nephropathy

Oxidative stress due to chronic hyperglycaemia is a key factor in the development and progression of various microvascular complications including diabetic nephropathy (DN) and associated renal injury. Treatment with antioxidants is one of the strategies to protect the kidney from oxidative tissue d...

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Autores principales:	Mahajan Manojkumar S., Upaganlawar Aman B., Upasani Chandrashekar D.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	diabetic nephropathy oxidative stress streptozotocin coenzyme q10 n-acetylcysteine Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/cab3b820a24e460fbc19dccfba845d11
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spelling	oai:doaj.org-article:cab3b820a24e460fbc19dccfba845d112021-12-05T14:11:05ZNephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic Nephropathy2453-672510.2478/afpuc-2020-0020https://doaj.org/article/cab3b820a24e460fbc19dccfba845d112021-06-01T00:00:00Zhttps://doi.org/10.2478/afpuc-2020-0020https://doaj.org/toc/2453-6725Oxidative stress due to chronic hyperglycaemia is a key factor in the development and progression of various microvascular complications including diabetic nephropathy (DN) and associated renal injury. Treatment with antioxidants is one of the strategies to protect the kidney from oxidative tissue damage to improve renal physiology during DN. The investigation, therefore, was designed to assess the nephroprotective effect of coenzyme Q10 (CoQ10) and N-acetylcysteine (NAC), either alone or in combination in streptozotocin (STZ)-nicotinamide (NAD) induced diabetic nephropathy (DN) in rats.Mahajan Manojkumar S.Upaganlawar Aman B.Upasani Chandrashekar D.Sciendoarticlediabetic nephropathyoxidative stressstreptozotocincoenzyme q10n-acetylcysteineTherapeutics. PharmacologyRM1-950ENEuropean Pharmaceutical Journal, Vol 68, Iss 1, Pp 30-39 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetic nephropathy oxidative stress streptozotocin coenzyme q10 n-acetylcysteine Therapeutics. Pharmacology RM1-950
spellingShingle	diabetic nephropathy oxidative stress streptozotocin coenzyme q10 n-acetylcysteine Therapeutics. Pharmacology RM1-950 Mahajan Manojkumar S. Upaganlawar Aman B. Upasani Chandrashekar D. Nephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic Nephropathy
description	Oxidative stress due to chronic hyperglycaemia is a key factor in the development and progression of various microvascular complications including diabetic nephropathy (DN) and associated renal injury. Treatment with antioxidants is one of the strategies to protect the kidney from oxidative tissue damage to improve renal physiology during DN. The investigation, therefore, was designed to assess the nephroprotective effect of coenzyme Q10 (CoQ10) and N-acetylcysteine (NAC), either alone or in combination in streptozotocin (STZ)-nicotinamide (NAD) induced diabetic nephropathy (DN) in rats.
format	article
author	Mahajan Manojkumar S. Upaganlawar Aman B. Upasani Chandrashekar D.
author_facet	Mahajan Manojkumar S. Upaganlawar Aman B. Upasani Chandrashekar D.
author_sort	Mahajan Manojkumar S.
title	Nephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic Nephropathy
title_short	Nephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic Nephropathy
title_full	Nephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic Nephropathy
title_fullStr	Nephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic Nephropathy
title_full_unstemmed	Nephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic Nephropathy
title_sort	nephroprotective effect of coenzyme q10 alone and in combination with n-acetylcysteine in diabetic nephropathy
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/cab3b820a24e460fbc19dccfba845d11
work_keys_str_mv	AT mahajanmanojkumars nephroprotectiveeffectofcoenzymeq10aloneandincombinationwithnacetylcysteineindiabeticnephropathy AT upaganlawaramanb nephroprotectiveeffectofcoenzymeq10aloneandincombinationwithnacetylcysteineindiabeticnephropathy AT upasanichandrashekard nephroprotectiveeffectofcoenzymeq10aloneandincombinationwithnacetylcysteineindiabeticnephropathy
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Nephroprotective Effect of Coenzyme Q10 alone and in Combination with N-acetylcysteine in Diabetic Nephropathy

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