Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth.
Gut microbiota has been implicated as a modifier of childhood growth. Here, 16S rRNA sequencing-based fecal microbiota profiles of 18-24 month old Indian children were evaluated (n = 41), in relation to their anthropometric parameters, intestinal permeability, body composition and total energy expen...
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oai:doaj.org-article:cab54c57905d45f7a6440ed61b3869a22021-11-25T06:19:14ZGut microbiota profiles of young South Indian children: Child sex-specific relations with growth.1932-620310.1371/journal.pone.0251803https://doaj.org/article/cab54c57905d45f7a6440ed61b3869a22021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251803https://doaj.org/toc/1932-6203Gut microbiota has been implicated as a modifier of childhood growth. Here, 16S rRNA sequencing-based fecal microbiota profiles of 18-24 month old Indian children were evaluated (n = 41), in relation to their anthropometric parameters, intestinal permeability, body composition and total energy expenditure. Pathway analyses were conducted to assess microbial functions related to stunting, underweight and wasting. The fecal microbiota was enriched in Prevotella 9, Bifidobacterium and Escherichia-Shigella. Weight, weight-for-age Z-scores (WAZ) and weight-for-length Z-scores (WLZ), along with age, acted as covariates of microbiota variation specifically in boys (n = 23). Bifidobacterium longum subsp longum abundance was positively associated with WAZ while Bifidobacterium bifidum and Bifidobacterium breve abundances were negatively associated with age. The lipopolysaccharide biosynthesis pathway was upregulated in stunted (n = 16) and wasted (n = 8) children. Findings from this study indicate that child sex may be a critical modifier of the role of gut microbiota on childhood growth.Nirupama ShivakumarAmbily SivadasSarita DeviFarook JahoorJohn McLaughlinCraig P SmithAnura V KurpadArpita MukhopadhyayPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251803 (2021) |
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Medicine R Science Q Nirupama Shivakumar Ambily Sivadas Sarita Devi Farook Jahoor John McLaughlin Craig P Smith Anura V Kurpad Arpita Mukhopadhyay Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth. |
| description |
Gut microbiota has been implicated as a modifier of childhood growth. Here, 16S rRNA sequencing-based fecal microbiota profiles of 18-24 month old Indian children were evaluated (n = 41), in relation to their anthropometric parameters, intestinal permeability, body composition and total energy expenditure. Pathway analyses were conducted to assess microbial functions related to stunting, underweight and wasting. The fecal microbiota was enriched in Prevotella 9, Bifidobacterium and Escherichia-Shigella. Weight, weight-for-age Z-scores (WAZ) and weight-for-length Z-scores (WLZ), along with age, acted as covariates of microbiota variation specifically in boys (n = 23). Bifidobacterium longum subsp longum abundance was positively associated with WAZ while Bifidobacterium bifidum and Bifidobacterium breve abundances were negatively associated with age. The lipopolysaccharide biosynthesis pathway was upregulated in stunted (n = 16) and wasted (n = 8) children. Findings from this study indicate that child sex may be a critical modifier of the role of gut microbiota on childhood growth. |
| format |
article |
| author |
Nirupama Shivakumar Ambily Sivadas Sarita Devi Farook Jahoor John McLaughlin Craig P Smith Anura V Kurpad Arpita Mukhopadhyay |
| author_facet |
Nirupama Shivakumar Ambily Sivadas Sarita Devi Farook Jahoor John McLaughlin Craig P Smith Anura V Kurpad Arpita Mukhopadhyay |
| author_sort |
Nirupama Shivakumar |
| title |
Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth. |
| title_short |
Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth. |
| title_full |
Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth. |
| title_fullStr |
Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth. |
| title_full_unstemmed |
Gut microbiota profiles of young South Indian children: Child sex-specific relations with growth. |
| title_sort |
gut microbiota profiles of young south indian children: child sex-specific relations with growth. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/cab54c57905d45f7a6440ed61b3869a2 |
| work_keys_str_mv |
AT nirupamashivakumar gutmicrobiotaprofilesofyoungsouthindianchildrenchildsexspecificrelationswithgrowth AT ambilysivadas gutmicrobiotaprofilesofyoungsouthindianchildrenchildsexspecificrelationswithgrowth AT saritadevi gutmicrobiotaprofilesofyoungsouthindianchildrenchildsexspecificrelationswithgrowth AT farookjahoor gutmicrobiotaprofilesofyoungsouthindianchildrenchildsexspecificrelationswithgrowth AT johnmclaughlin gutmicrobiotaprofilesofyoungsouthindianchildrenchildsexspecificrelationswithgrowth AT craigpsmith gutmicrobiotaprofilesofyoungsouthindianchildrenchildsexspecificrelationswithgrowth AT anuravkurpad gutmicrobiotaprofilesofyoungsouthindianchildrenchildsexspecificrelationswithgrowth AT arpitamukhopadhyay gutmicrobiotaprofilesofyoungsouthindianchildrenchildsexspecificrelationswithgrowth |
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