HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells

Organ regeneration by transplantation of ESC/iPSC-derived tissues is a promising but still challenging approach. Here Lin et al. show that liver damage caused by a chemical insult induces not only fibrosis but also Lgr5+ cell expansion that can be further promoted by treatment with HGF/R-spondin1.

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Autores principales:	Yuan Lin, Zhe-Ping Fang, Hong-Juan Liu, Li-Jing Wang, Zhiqiang Cheng, Na Tang, Tingting Li, Tengfei Liu, Hai-Xiong Han, Guangwen Cao, Li Liang, Yan-Qing Ding, Wei-Jie Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cab654a367c941948d9cd8ac4d0be63a
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spelling	oai:doaj.org-article:cab654a367c941948d9cd8ac4d0be63a2021-12-02T14:40:45ZHGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells10.1038/s41467-017-01341-62041-1723https://doaj.org/article/cab654a367c941948d9cd8ac4d0be63a2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01341-6https://doaj.org/toc/2041-1723Organ regeneration by transplantation of ESC/iPSC-derived tissues is a promising but still challenging approach. Here Lin et al. show that liver damage caused by a chemical insult induces not only fibrosis but also Lgr5+ cell expansion that can be further promoted by treatment with HGF/R-spondin1.Yuan LinZhe-Ping FangHong-Juan LiuLi-Jing WangZhiqiang ChengNa TangTingting LiTengfei LiuHai-Xiong HanGuangwen CaoLi LiangYan-Qing DingWei-Jie ZhouNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuan Lin Zhe-Ping Fang Hong-Juan Liu Li-Jing Wang Zhiqiang Cheng Na Tang Tingting Li Tengfei Liu Hai-Xiong Han Guangwen Cao Li Liang Yan-Qing Ding Wei-Jie Zhou HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells
description	Organ regeneration by transplantation of ESC/iPSC-derived tissues is a promising but still challenging approach. Here Lin et al. show that liver damage caused by a chemical insult induces not only fibrosis but also Lgr5+ cell expansion that can be further promoted by treatment with HGF/R-spondin1.
format	article
author	Yuan Lin Zhe-Ping Fang Hong-Juan Liu Li-Jing Wang Zhiqiang Cheng Na Tang Tingting Li Tengfei Liu Hai-Xiong Han Guangwen Cao Li Liang Yan-Qing Ding Wei-Jie Zhou
author_facet	Yuan Lin Zhe-Ping Fang Hong-Juan Liu Li-Jing Wang Zhiqiang Cheng Na Tang Tingting Li Tengfei Liu Hai-Xiong Han Guangwen Cao Li Liang Yan-Qing Ding Wei-Jie Zhou
author_sort	Yuan Lin
title	HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells
title_short	HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells
title_full	HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells
title_fullStr	HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells
title_full_unstemmed	HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells
title_sort	hgf/r-spondin1 rescues liver dysfunction through the induction of lgr5+ liver stem cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cab654a367c941948d9cd8ac4d0be63a
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HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells

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