HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells

HGF/R-spondin1 rescues liver dysfunction through the induction of Lgr5+ liver stem cells

Organ regeneration by transplantation of ESC/iPSC-derived tissues is a promising but still challenging approach. Here Lin et al. show that liver damage caused by a chemical insult induces not only fibrosis but also Lgr5+ cell expansion that can be further promoted by treatment with HGF/R-spondin1.

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Detalles Bibliográficos
Autores principales: Yuan Lin, Zhe-Ping Fang, Hong-Juan Liu, Li-Jing Wang, Zhiqiang Cheng, Na Tang, Tingting Li, Tengfei Liu, Hai-Xiong Han, Guangwen Cao, Li Liang, Yan-Qing Ding, Wei-Jie Zhou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/cab654a367c941948d9cd8ac4d0be63a
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