Single-cell variability in multicellular organisms

While gene expression noise in single-celled organisms is well understood, it is less so in the context of tissues. Here the authors show that coupling between cells in tissues can increase or decrease cell-to-cell variability depending on the level of noise intrinsic to the regulatory networks.

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Detalles Bibliográficos
Autores principales:	Stephen Smith, Ramon Grima
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cab872a9570d477dbfe85626517b38bc
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spelling	oai:doaj.org-article:cab872a9570d477dbfe85626517b38bc2021-12-02T15:33:36ZSingle-cell variability in multicellular organisms10.1038/s41467-017-02710-x2041-1723https://doaj.org/article/cab872a9570d477dbfe85626517b38bc2018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02710-xhttps://doaj.org/toc/2041-1723While gene expression noise in single-celled organisms is well understood, it is less so in the context of tissues. Here the authors show that coupling between cells in tissues can increase or decrease cell-to-cell variability depending on the level of noise intrinsic to the regulatory networks.Stephen SmithRamon GrimaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephen Smith Ramon Grima Single-cell variability in multicellular organisms
description	While gene expression noise in single-celled organisms is well understood, it is less so in the context of tissues. Here the authors show that coupling between cells in tissues can increase or decrease cell-to-cell variability depending on the level of noise intrinsic to the regulatory networks.
format	article
author	Stephen Smith Ramon Grima
author_facet	Stephen Smith Ramon Grima
author_sort	Stephen Smith
title	Single-cell variability in multicellular organisms
title_short	Single-cell variability in multicellular organisms
title_full	Single-cell variability in multicellular organisms
title_fullStr	Single-cell variability in multicellular organisms
title_full_unstemmed	Single-cell variability in multicellular organisms
title_sort	single-cell variability in multicellular organisms
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cab872a9570d477dbfe85626517b38bc
work_keys_str_mv	AT stephensmith singlecellvariabilityinmulticellularorganisms AT ramongrima singlecellvariabilityinmulticellularorganisms
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Single-cell variability in multicellular organisms

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