Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors

Glucocorticoid hormones (GCs) are of critical importance for maintaining brain health, but their involvement in mental disorders is poorly understood. Here the authors show how GCs act through hippocampal mineralocorticoid and glucocorticoid receptors to impact the gene regulatory programs underpinn...

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Auteurs principaux:	Karen R. Mifsud, Clare L. M. Kennedy, Silvia Salatino, Eshita Sharma, Emily M. Price, Samantha N. Haque, Andriana Gialeli, Hannah M. Goss, Polina E. Panchenko, John Broxholme, Simon Engledow, Helen Lockstone, Oscar Cordero Llana, Johannes M. H. M. Reul
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/cab8e81fe2db49c6b2482e6a7549ae9b
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spelling	oai:doaj.org-article:cab8e81fe2db49c6b2482e6a7549ae9b2021-12-02T14:53:37ZDistinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors10.1038/s41467-021-24967-z2041-1723https://doaj.org/article/cab8e81fe2db49c6b2482e6a7549ae9b2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24967-zhttps://doaj.org/toc/2041-1723Glucocorticoid hormones (GCs) are of critical importance for maintaining brain health, but their involvement in mental disorders is poorly understood. Here the authors show how GCs act through hippocampal mineralocorticoid and glucocorticoid receptors to impact the gene regulatory programs underpinning neuronal plasticity, ciliogenesis and behavioral adaptation.Karen R. MifsudClare L. M. KennedySilvia SalatinoEshita SharmaEmily M. PriceSamantha N. HaqueAndriana GialeliHannah M. GossPolina E. PanchenkoJohn BroxholmeSimon EngledowHelen LockstoneOscar Cordero LlanaJohannes M. H. M. ReulNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-23 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karen R. Mifsud Clare L. M. Kennedy Silvia Salatino Eshita Sharma Emily M. Price Samantha N. Haque Andriana Gialeli Hannah M. Goss Polina E. Panchenko John Broxholme Simon Engledow Helen Lockstone Oscar Cordero Llana Johannes M. H. M. Reul Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors
description	Glucocorticoid hormones (GCs) are of critical importance for maintaining brain health, but their involvement in mental disorders is poorly understood. Here the authors show how GCs act through hippocampal mineralocorticoid and glucocorticoid receptors to impact the gene regulatory programs underpinning neuronal plasticity, ciliogenesis and behavioral adaptation.
format	article
author	Karen R. Mifsud Clare L. M. Kennedy Silvia Salatino Eshita Sharma Emily M. Price Samantha N. Haque Andriana Gialeli Hannah M. Goss Polina E. Panchenko John Broxholme Simon Engledow Helen Lockstone Oscar Cordero Llana Johannes M. H. M. Reul
author_facet	Karen R. Mifsud Clare L. M. Kennedy Silvia Salatino Eshita Sharma Emily M. Price Samantha N. Haque Andriana Gialeli Hannah M. Goss Polina E. Panchenko John Broxholme Simon Engledow Helen Lockstone Oscar Cordero Llana Johannes M. H. M. Reul
author_sort	Karen R. Mifsud
title	Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors
title_short	Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors
title_full	Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors
title_fullStr	Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors
title_full_unstemmed	Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors
title_sort	distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cab8e81fe2db49c6b2482e6a7549ae9b
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Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors

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