Formation, contents, functions of exosomes and their potential in lung cancer diagnostics and therapeutics
Abstract Lung cancer is the leading cause of cancer‐related death worldwide due to diagnosis in the advanced stage and drug resistance in the subsequent treatments. Development of novel diagnostic and therapeutic methods is urged to improve the disease outcome. Exosomes are nano‐sized vehicles which...
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Wiley
2021
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oai:doaj.org-article:cabb4b3448564567bd7770b90d913ee92021-12-02T02:34:55ZFormation, contents, functions of exosomes and their potential in lung cancer diagnostics and therapeutics1759-77141759-770610.1111/1759-7714.14217https://doaj.org/article/cabb4b3448564567bd7770b90d913ee92021-12-01T00:00:00Zhttps://doi.org/10.1111/1759-7714.14217https://doaj.org/toc/1759-7706https://doaj.org/toc/1759-7714Abstract Lung cancer is the leading cause of cancer‐related death worldwide due to diagnosis in the advanced stage and drug resistance in the subsequent treatments. Development of novel diagnostic and therapeutic methods is urged to improve the disease outcome. Exosomes are nano‐sized vehicles which transport different types of biomolecules intercellularly, including DNA, RNA and proteins, and are implicated in cross‐talk between cells and their surrounding microenvironment. Tumor‐derived exosomes (TEXs) have been revealed to strongly influence the tumor microenvironment, antitumor immunoregulatory activities, tumor progression and metastasis. Potential of TEXs as biomarkers for lung cancer diagnosis, prognosis and treatment prediction is supported by numerous studies. Moreover, exosomes have been proposed to be promising drug carriers. Here, we review the mechanisms of exosomal formation and uptake, the functions of exosomes in carcinogenesis, and potential clinical utility of exosomes as biomarkers, tumor vaccine and drug delivery vehicles in the diagnosis and therapeutics of lung cancer.Zhenkun XiaBei QingWei WangLinguo GuHongzuo ChenYunchang YuanWileyarticlebiomarkerdiagnosisexosomelung cancertumor‐derived exosomeNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENThoracic Cancer, Vol 12, Iss 23, Pp 3088-3100 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
biomarker diagnosis exosome lung cancer tumor‐derived exosome Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
biomarker diagnosis exosome lung cancer tumor‐derived exosome Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Zhenkun Xia Bei Qing Wei Wang Linguo Gu Hongzuo Chen Yunchang Yuan Formation, contents, functions of exosomes and their potential in lung cancer diagnostics and therapeutics |
| description |
Abstract Lung cancer is the leading cause of cancer‐related death worldwide due to diagnosis in the advanced stage and drug resistance in the subsequent treatments. Development of novel diagnostic and therapeutic methods is urged to improve the disease outcome. Exosomes are nano‐sized vehicles which transport different types of biomolecules intercellularly, including DNA, RNA and proteins, and are implicated in cross‐talk between cells and their surrounding microenvironment. Tumor‐derived exosomes (TEXs) have been revealed to strongly influence the tumor microenvironment, antitumor immunoregulatory activities, tumor progression and metastasis. Potential of TEXs as biomarkers for lung cancer diagnosis, prognosis and treatment prediction is supported by numerous studies. Moreover, exosomes have been proposed to be promising drug carriers. Here, we review the mechanisms of exosomal formation and uptake, the functions of exosomes in carcinogenesis, and potential clinical utility of exosomes as biomarkers, tumor vaccine and drug delivery vehicles in the diagnosis and therapeutics of lung cancer. |
| format |
article |
| author |
Zhenkun Xia Bei Qing Wei Wang Linguo Gu Hongzuo Chen Yunchang Yuan |
| author_facet |
Zhenkun Xia Bei Qing Wei Wang Linguo Gu Hongzuo Chen Yunchang Yuan |
| author_sort |
Zhenkun Xia |
| title |
Formation, contents, functions of exosomes and their potential in lung cancer diagnostics and therapeutics |
| title_short |
Formation, contents, functions of exosomes and their potential in lung cancer diagnostics and therapeutics |
| title_full |
Formation, contents, functions of exosomes and their potential in lung cancer diagnostics and therapeutics |
| title_fullStr |
Formation, contents, functions of exosomes and their potential in lung cancer diagnostics and therapeutics |
| title_full_unstemmed |
Formation, contents, functions of exosomes and their potential in lung cancer diagnostics and therapeutics |
| title_sort |
formation, contents, functions of exosomes and their potential in lung cancer diagnostics and therapeutics |
| publisher |
Wiley |
| publishDate |
2021 |
| url |
https://doaj.org/article/cabb4b3448564567bd7770b90d913ee9 |
| work_keys_str_mv |
AT zhenkunxia formationcontentsfunctionsofexosomesandtheirpotentialinlungcancerdiagnosticsandtherapeutics AT beiqing formationcontentsfunctionsofexosomesandtheirpotentialinlungcancerdiagnosticsandtherapeutics AT weiwang formationcontentsfunctionsofexosomesandtheirpotentialinlungcancerdiagnosticsandtherapeutics AT linguogu formationcontentsfunctionsofexosomesandtheirpotentialinlungcancerdiagnosticsandtherapeutics AT hongzuochen formationcontentsfunctionsofexosomesandtheirpotentialinlungcancerdiagnosticsandtherapeutics AT yunchangyuan formationcontentsfunctionsofexosomesandtheirpotentialinlungcancerdiagnosticsandtherapeutics |
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1718402374944423936 |