Moderate plasma dilution using artificial plasma expanders shifts the haemostatic balance to hypercoagulation

Abstract Artificial plasma expanders (PEs) are widely used in modern transfusion medicine. PEs do not contain components of the coagulation system, so their infusion in large volumes causes haemodilution and affects haemostasis. However, the existing information on this effect is contradictory. We s...

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Autores principales:	Elena I. Sinauridze, Alexander S. Gorbatenko, Elena A. Seregina, Elena N. Lipets, Fazoil I. Ataullakhanov
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cabeb134f4034f4e806afaa83c3cc50a
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spelling	oai:doaj.org-article:cabeb134f4034f4e806afaa83c3cc50a2021-12-02T11:52:42ZModerate plasma dilution using artificial plasma expanders shifts the haemostatic balance to hypercoagulation10.1038/s41598-017-00927-w2045-2322https://doaj.org/article/cabeb134f4034f4e806afaa83c3cc50a2017-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00927-whttps://doaj.org/toc/2045-2322Abstract Artificial plasma expanders (PEs) are widely used in modern transfusion medicine. PEs do not contain components of the coagulation system, so their infusion in large volumes causes haemodilution and affects haemostasis. However, the existing information on this effect is contradictory. We studied the effect of the very process of plasma dilution on coagulation and tested the hypothesis that moderate dilution with a PE should accelerate clotting owing to a decrease in concentration of coagulation inhibitors. The standard clotting times, a thrombin generation test, and the spatial rate of clot growth (test of thrombodynamics) were used to assess donor plasma diluted in vitro with various PEs. The pH value and Ca+2 concentration were maintained strictly constant in all samples. The effect of thrombin inhibitors on dilution-induced hypercoagulation was also examined. It was shown that coagulation was enhanced in plasma diluted up to 2.0–2.5-fold with any PE. This enhancement was due to the dilution of coagulation inhibitors in plasma. Their addition to plasma or PE could partially prevent the hypercoagulation shift.Elena I. SinauridzeAlexander S. GorbatenkoElena A. SereginaElena N. LipetsFazoil I. AtaullakhanovNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elena I. Sinauridze Alexander S. Gorbatenko Elena A. Seregina Elena N. Lipets Fazoil I. Ataullakhanov Moderate plasma dilution using artificial plasma expanders shifts the haemostatic balance to hypercoagulation
description	Abstract Artificial plasma expanders (PEs) are widely used in modern transfusion medicine. PEs do not contain components of the coagulation system, so their infusion in large volumes causes haemodilution and affects haemostasis. However, the existing information on this effect is contradictory. We studied the effect of the very process of plasma dilution on coagulation and tested the hypothesis that moderate dilution with a PE should accelerate clotting owing to a decrease in concentration of coagulation inhibitors. The standard clotting times, a thrombin generation test, and the spatial rate of clot growth (test of thrombodynamics) were used to assess donor plasma diluted in vitro with various PEs. The pH value and Ca+2 concentration were maintained strictly constant in all samples. The effect of thrombin inhibitors on dilution-induced hypercoagulation was also examined. It was shown that coagulation was enhanced in plasma diluted up to 2.0–2.5-fold with any PE. This enhancement was due to the dilution of coagulation inhibitors in plasma. Their addition to plasma or PE could partially prevent the hypercoagulation shift.
format	article
author	Elena I. Sinauridze Alexander S. Gorbatenko Elena A. Seregina Elena N. Lipets Fazoil I. Ataullakhanov
author_facet	Elena I. Sinauridze Alexander S. Gorbatenko Elena A. Seregina Elena N. Lipets Fazoil I. Ataullakhanov
author_sort	Elena I. Sinauridze
title	Moderate plasma dilution using artificial plasma expanders shifts the haemostatic balance to hypercoagulation
title_short	Moderate plasma dilution using artificial plasma expanders shifts the haemostatic balance to hypercoagulation
title_full	Moderate plasma dilution using artificial plasma expanders shifts the haemostatic balance to hypercoagulation
title_fullStr	Moderate plasma dilution using artificial plasma expanders shifts the haemostatic balance to hypercoagulation
title_full_unstemmed	Moderate plasma dilution using artificial plasma expanders shifts the haemostatic balance to hypercoagulation
title_sort	moderate plasma dilution using artificial plasma expanders shifts the haemostatic balance to hypercoagulation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cabeb134f4034f4e806afaa83c3cc50a
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Moderate plasma dilution using artificial plasma expanders shifts the haemostatic balance to hypercoagulation

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