Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors

Functional cardiac fibroblasts derived from human pluripotent stem cells via second heart field progenitors

Cardiac fibroblasts (CFs) play critical roles in heart development, homeostasis, and disease. Here the authors efficiently differentiate human pluripotent stem cells through second heart field progenitors to CFs that exhibit features and functional properties similar to native CFs.

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Detalles Bibliográficos
Autores principales: Jianhua Zhang, Ran Tao, Katherine F. Campbell, Juliana L. Carvalho, Edward C. Ruiz, Gina C. Kim, Eric G. Schmuck, Amish N. Raval, André Monteiro da Rocha, Todd J. Herron, José Jalife, James A. Thomson, Timothy J. Kamp
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/cac0b63036aa4319872cc66f34cdaf9b
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Descripción
Sumario:Cardiac fibroblasts (CFs) play critical roles in heart development, homeostasis, and disease. Here the authors efficiently differentiate human pluripotent stem cells through second heart field progenitors to CFs that exhibit features and functional properties similar to native CFs.

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