Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection

Long-lived IgG plasma cells develop in germinal centres and then home to the bone marrow and persist for a lifetime. Here the authors identify long-lived IgM plasma cells in the murine spleen, which carry IgH mutations but can develop independently of germinal centres, and confer protective antivira...

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Autores principales:	Caitlin Bohannon, Ryan Powers, Lakshmipriyadarshini Satyabhama, Ang Cui, Christopher Tipton, Miri Michaeli, Ioanna Skountzou, Robert S. Mittler, Steven H. Kleinstein, Ramit Mehr, Frances Eun-Yun Lee, Ignacio Sanz, Joshy Jacob
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cac2164087834241a0295662d5889fe7
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spelling	oai:doaj.org-article:cac2164087834241a0295662d5889fe72021-12-02T17:31:49ZLong-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection10.1038/ncomms118262041-1723https://doaj.org/article/cac2164087834241a0295662d5889fe72016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11826https://doaj.org/toc/2041-1723Long-lived IgG plasma cells develop in germinal centres and then home to the bone marrow and persist for a lifetime. Here the authors identify long-lived IgM plasma cells in the murine spleen, which carry IgH mutations but can develop independently of germinal centres, and confer protective antiviral immunity.Caitlin BohannonRyan PowersLakshmipriyadarshini SatyabhamaAng CuiChristopher TiptonMiri MichaeliIoanna SkountzouRobert S. MittlerSteven H. KleinsteinRamit MehrFrances Eun-Yun LeeIgnacio SanzJoshy JacobNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Caitlin Bohannon Ryan Powers Lakshmipriyadarshini Satyabhama Ang Cui Christopher Tipton Miri Michaeli Ioanna Skountzou Robert S. Mittler Steven H. Kleinstein Ramit Mehr Frances Eun-Yun Lee Ignacio Sanz Joshy Jacob Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection
description	Long-lived IgG plasma cells develop in germinal centres and then home to the bone marrow and persist for a lifetime. Here the authors identify long-lived IgM plasma cells in the murine spleen, which carry IgH mutations but can develop independently of germinal centres, and confer protective antiviral immunity.
format	article
author	Caitlin Bohannon Ryan Powers Lakshmipriyadarshini Satyabhama Ang Cui Christopher Tipton Miri Michaeli Ioanna Skountzou Robert S. Mittler Steven H. Kleinstein Ramit Mehr Frances Eun-Yun Lee Ignacio Sanz Joshy Jacob
author_facet	Caitlin Bohannon Ryan Powers Lakshmipriyadarshini Satyabhama Ang Cui Christopher Tipton Miri Michaeli Ioanna Skountzou Robert S. Mittler Steven H. Kleinstein Ramit Mehr Frances Eun-Yun Lee Ignacio Sanz Joshy Jacob
author_sort	Caitlin Bohannon
title	Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection
title_short	Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection
title_full	Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection
title_fullStr	Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection
title_full_unstemmed	Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection
title_sort	long-lived antigen-induced igm plasma cells demonstrate somatic mutations and contribute to long-term protection
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/cac2164087834241a0295662d5889fe7
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Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection

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