Regression of tumor thrombus in the suprahepatic vena cava of hepatocellular carcinoma and conversion hepatectomy induced by lenvatinib

Abstract Recent developments in systemic chemotherapy for advanced hepatocellular carcinoma have been outstanding. However, reports on conversion surgery after lenvatinib therapy are scarce. We present the first case of advanced hepatocellular carcinoma with tumor thrombus in the suprahepatic vena...

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Autores principales:	Ryota Matsuki, Naohiro Okano, Takaaki Arai, Shinya Yoshiike, Masaharu Kogure, Yutaka Suzuki, Junji Shibahara, Junji Furuse, Yoshihiro Sakamoto
Formato:	article
Lenguaje:	EN
Publicado:	Karger Publishers 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/cac56efedcaa4870b775feb85b21e7f6
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spelling	oai:doaj.org-article:cac56efedcaa4870b775feb85b21e7f62021-12-02T12:40:23ZRegression of tumor thrombus in the suprahepatic vena cava of hepatocellular carcinoma and conversion hepatectomy induced by lenvatinib2235-17951664-555310.1159/000520822https://doaj.org/article/cac56efedcaa4870b775feb85b21e7f62021-11-01T00:00:00Zhttps://www.karger.com/Article/FullText/520822https://doaj.org/toc/2235-1795https://doaj.org/toc/1664-5553Abstract Recent developments in systemic chemotherapy for advanced hepatocellular carcinoma have been outstanding. However, reports on conversion surgery after lenvatinib therapy are scarce. We present the first case of advanced hepatocellular carcinoma with tumor thrombus in the suprahepatic vena cava close to the right atrium, which shrank after 12 weeks’ administration of lenvatinib, thereby leading to successful conversion surgery without using total vascular exclusion or extracorporeal circulation. The treatment strategy for hepatocellular carcinoma with macroscopic hepatic vein tumor thrombus is controversial, however, from a Japanese nationwide survey, surgical resection has been accepted as one of the treatment options for advanced hepatocellular carcinoma with hepatic vein tumor thrombus in Japan. However, the survival rate after resection of hepatocellular carcinoma having inferior vena cava tumor thrombus with extracorporeal circulation was reported to be worse than without extracorporeal circulation, and some preoperative down-sizing therapy for inferior vena cava tumor thrombus was advocated. Preoperative lenvatinib therapy might be a promising option among the multidisciplinary treatments for hepatocellular carcinoma with macroscopic tumor thrombus in the hepatic veins.Ryota MatsukiNaohiro OkanoTakaaki AraiShinya YoshiikeMasaharu KogureYutaka SuzukiJunji ShibaharaJunji FuruseYoshihiro SakamotoKarger PublishersarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENLiver Cancer (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Ryota Matsuki Naohiro Okano Takaaki Arai Shinya Yoshiike Masaharu Kogure Yutaka Suzuki Junji Shibahara Junji Furuse Yoshihiro Sakamoto Regression of tumor thrombus in the suprahepatic vena cava of hepatocellular carcinoma and conversion hepatectomy induced by lenvatinib
description	Abstract Recent developments in systemic chemotherapy for advanced hepatocellular carcinoma have been outstanding. However, reports on conversion surgery after lenvatinib therapy are scarce. We present the first case of advanced hepatocellular carcinoma with tumor thrombus in the suprahepatic vena cava close to the right atrium, which shrank after 12 weeks’ administration of lenvatinib, thereby leading to successful conversion surgery without using total vascular exclusion or extracorporeal circulation. The treatment strategy for hepatocellular carcinoma with macroscopic hepatic vein tumor thrombus is controversial, however, from a Japanese nationwide survey, surgical resection has been accepted as one of the treatment options for advanced hepatocellular carcinoma with hepatic vein tumor thrombus in Japan. However, the survival rate after resection of hepatocellular carcinoma having inferior vena cava tumor thrombus with extracorporeal circulation was reported to be worse than without extracorporeal circulation, and some preoperative down-sizing therapy for inferior vena cava tumor thrombus was advocated. Preoperative lenvatinib therapy might be a promising option among the multidisciplinary treatments for hepatocellular carcinoma with macroscopic tumor thrombus in the hepatic veins.
format	article
author	Ryota Matsuki Naohiro Okano Takaaki Arai Shinya Yoshiike Masaharu Kogure Yutaka Suzuki Junji Shibahara Junji Furuse Yoshihiro Sakamoto
author_facet	Ryota Matsuki Naohiro Okano Takaaki Arai Shinya Yoshiike Masaharu Kogure Yutaka Suzuki Junji Shibahara Junji Furuse Yoshihiro Sakamoto
author_sort	Ryota Matsuki
title	Regression of tumor thrombus in the suprahepatic vena cava of hepatocellular carcinoma and conversion hepatectomy induced by lenvatinib
title_short	Regression of tumor thrombus in the suprahepatic vena cava of hepatocellular carcinoma and conversion hepatectomy induced by lenvatinib
title_full	Regression of tumor thrombus in the suprahepatic vena cava of hepatocellular carcinoma and conversion hepatectomy induced by lenvatinib
title_fullStr	Regression of tumor thrombus in the suprahepatic vena cava of hepatocellular carcinoma and conversion hepatectomy induced by lenvatinib
title_full_unstemmed	Regression of tumor thrombus in the suprahepatic vena cava of hepatocellular carcinoma and conversion hepatectomy induced by lenvatinib
title_sort	regression of tumor thrombus in the suprahepatic vena cava of hepatocellular carcinoma and conversion hepatectomy induced by lenvatinib
publisher	Karger Publishers
publishDate	2021
url	https://doaj.org/article/cac56efedcaa4870b775feb85b21e7f6
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Regression of tumor thrombus in the suprahepatic vena cava of hepatocellular carcinoma and conversion hepatectomy induced by lenvatinib

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