Automated Quantification of Early Bone Alterations and Pathological Bone Turnover in Experimental Arthritis by in vivo PET/CT Imaging

Abstract The assessment of bone damage is required to evaluate disease severity and treatment efficacy both in arthritis patients and in experimental arthritis models. Today there is still a lack of in vivo methods that enable the quantification of arthritic processes at an early stage of the diseas...

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Autores principales:	Bianca Hoffmann, Carl-Magnus Svensson, Maria Straßburger, Björn Gebser, Ingo M. Irmler, Thomas Kamradt, Hans Peter Saluz, Marc Thilo Figge
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cacc0218165e466c83adae775fca26db
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spelling	oai:doaj.org-article:cacc0218165e466c83adae775fca26db2021-12-02T16:06:29ZAutomated Quantification of Early Bone Alterations and Pathological Bone Turnover in Experimental Arthritis by in vivo PET/CT Imaging10.1038/s41598-017-02389-62045-2322https://doaj.org/article/cacc0218165e466c83adae775fca26db2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02389-6https://doaj.org/toc/2045-2322Abstract The assessment of bone damage is required to evaluate disease severity and treatment efficacy both in arthritis patients and in experimental arthritis models. Today there is still a lack of in vivo methods that enable the quantification of arthritic processes at an early stage of the disease. We performed longitudinal in vivo imaging with [18F]-fluoride PET/CT before and after experimental arthritis onset for diseased and control DBA/1 mice and assessed arthritis progression by clinical scoring, tracer uptake studies and bone volume as well as surface roughness measurements. Arthritic animals showed significantly increased tracer uptake in the paws compared to non-diseased controls. Automated CT image analysis revealed increased bone surface roughness already in the earliest stage of the disease. Moreover, we observed clear differences between endosteal and periosteal sites of cortical bone regarding surface roughness. This study shows that in vivo PET/CT imaging is a favorable method to study arthritic processes, enabling the quantification of different aspects of the disease like pathological bone turnover and bone alteration. Especially the evaluation of bone surface roughness is sensitive to early pathological changes and can be applied to study the dynamics of bone erosion at different sites of the bones in an automated fashion.Bianca HoffmannCarl-Magnus SvenssonMaria StraßburgerBjörn GebserIngo M. IrmlerThomas KamradtHans Peter SaluzMarc Thilo FiggeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Bianca Hoffmann Carl-Magnus Svensson Maria Straßburger Björn Gebser Ingo M. Irmler Thomas Kamradt Hans Peter Saluz Marc Thilo Figge Automated Quantification of Early Bone Alterations and Pathological Bone Turnover in Experimental Arthritis by in vivo PET/CT Imaging
description	Abstract The assessment of bone damage is required to evaluate disease severity and treatment efficacy both in arthritis patients and in experimental arthritis models. Today there is still a lack of in vivo methods that enable the quantification of arthritic processes at an early stage of the disease. We performed longitudinal in vivo imaging with [18F]-fluoride PET/CT before and after experimental arthritis onset for diseased and control DBA/1 mice and assessed arthritis progression by clinical scoring, tracer uptake studies and bone volume as well as surface roughness measurements. Arthritic animals showed significantly increased tracer uptake in the paws compared to non-diseased controls. Automated CT image analysis revealed increased bone surface roughness already in the earliest stage of the disease. Moreover, we observed clear differences between endosteal and periosteal sites of cortical bone regarding surface roughness. This study shows that in vivo PET/CT imaging is a favorable method to study arthritic processes, enabling the quantification of different aspects of the disease like pathological bone turnover and bone alteration. Especially the evaluation of bone surface roughness is sensitive to early pathological changes and can be applied to study the dynamics of bone erosion at different sites of the bones in an automated fashion.
format	article
author	Bianca Hoffmann Carl-Magnus Svensson Maria Straßburger Björn Gebser Ingo M. Irmler Thomas Kamradt Hans Peter Saluz Marc Thilo Figge
author_facet	Bianca Hoffmann Carl-Magnus Svensson Maria Straßburger Björn Gebser Ingo M. Irmler Thomas Kamradt Hans Peter Saluz Marc Thilo Figge
author_sort	Bianca Hoffmann
title	Automated Quantification of Early Bone Alterations and Pathological Bone Turnover in Experimental Arthritis by in vivo PET/CT Imaging
title_short	Automated Quantification of Early Bone Alterations and Pathological Bone Turnover in Experimental Arthritis by in vivo PET/CT Imaging
title_full	Automated Quantification of Early Bone Alterations and Pathological Bone Turnover in Experimental Arthritis by in vivo PET/CT Imaging
title_fullStr	Automated Quantification of Early Bone Alterations and Pathological Bone Turnover in Experimental Arthritis by in vivo PET/CT Imaging
title_full_unstemmed	Automated Quantification of Early Bone Alterations and Pathological Bone Turnover in Experimental Arthritis by in vivo PET/CT Imaging
title_sort	automated quantification of early bone alterations and pathological bone turnover in experimental arthritis by in vivo pet/ct imaging
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cacc0218165e466c83adae775fca26db
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Automated Quantification of Early Bone Alterations and Pathological Bone Turnover in Experimental Arthritis by in vivo PET/CT Imaging

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