CXCR3 CHEMOKINE RECEPTOR EXPRESSION ON PERIPHERAL BLOOD B-CELL SUBSETS IN PATIENTS WITH CHRONIC HEPATITIS C

Abstract. Present study was aimed to perform a quantitative determination of B lymphocyte subpopulations, i.e., B1, B2, memory B cells and CXCR3-positive B cells in peripheral blood of nineteen patients with chronic hepatitis C (HCV) and thirty-two healthy blood donors. Phenotyping of B cell subsets...

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Autores principales:	N. A. Arsentieva, I. V. Kudryavtsev, D. S. Elezov, A. V. Semenov, E. V. Esaulenko, V. V. Basina, Areg A. Totolian
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	hepatitis c b-cells chemokines cxcr3 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/cacc551d027b4fc99a5a77b03f4a78c8
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spelling	oai:doaj.org-article:cacc551d027b4fc99a5a77b03f4a78c82021-11-18T08:03:43ZCXCR3 CHEMOKINE RECEPTOR EXPRESSION ON PERIPHERAL BLOOD B-CELL SUBSETS IN PATIENTS WITH CHRONIC HEPATITIS C1563-06252313-741X10.15789/1563-0625-2013-5-471-476https://doaj.org/article/cacc551d027b4fc99a5a77b03f4a78c82014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/664https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Present study was aimed to perform a quantitative determination of B lymphocyte subpopulations, i.e., B1, B2, memory B cells and CXCR3-positive B cells in peripheral blood of nineteen patients with chronic hepatitis C (HCV) and thirty-two healthy blood donors. Phenotyping of B cell subsets was performed by means of flow cytometry, using a combination of specific monoclonal antibodies, i.e., CD5-FITC/CD27-PC7/CXCR3-APC/CD19-APC-AF700/CD45-APC-AF750. Total numbers of B-lymphocytes and their subpopulations in peripheral blood of HCV-infected patients did not differ from appropriate values in control group. Meanwhile, expression of CXCR3 chemokine receptor in HCV patients proved to be significantly increased in all subsets of B cells. These results suggest a possible involvement of CXCR3-positive B cells into pathogenesis of chronic HCV infection.N. A. ArsentievaI. V. KudryavtsevD. S. ElezovA. V. SemenovE. V. EsaulenkoV. V. BasinaAreg A. TotolianSPb RAACIarticlehepatitis cb-cellschemokinescxcr3Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 5, Pp 471-476 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	hepatitis c b-cells chemokines cxcr3 Immunologic diseases. Allergy RC581-607
spellingShingle	hepatitis c b-cells chemokines cxcr3 Immunologic diseases. Allergy RC581-607 N. A. Arsentieva I. V. Kudryavtsev D. S. Elezov A. V. Semenov E. V. Esaulenko V. V. Basina Areg A. Totolian CXCR3 CHEMOKINE RECEPTOR EXPRESSION ON PERIPHERAL BLOOD B-CELL SUBSETS IN PATIENTS WITH CHRONIC HEPATITIS C
description	Abstract. Present study was aimed to perform a quantitative determination of B lymphocyte subpopulations, i.e., B1, B2, memory B cells and CXCR3-positive B cells in peripheral blood of nineteen patients with chronic hepatitis C (HCV) and thirty-two healthy blood donors. Phenotyping of B cell subsets was performed by means of flow cytometry, using a combination of specific monoclonal antibodies, i.e., CD5-FITC/CD27-PC7/CXCR3-APC/CD19-APC-AF700/CD45-APC-AF750. Total numbers of B-lymphocytes and their subpopulations in peripheral blood of HCV-infected patients did not differ from appropriate values in control group. Meanwhile, expression of CXCR3 chemokine receptor in HCV patients proved to be significantly increased in all subsets of B cells. These results suggest a possible involvement of CXCR3-positive B cells into pathogenesis of chronic HCV infection.
format	article
author	N. A. Arsentieva I. V. Kudryavtsev D. S. Elezov A. V. Semenov E. V. Esaulenko V. V. Basina Areg A. Totolian
author_facet	N. A. Arsentieva I. V. Kudryavtsev D. S. Elezov A. V. Semenov E. V. Esaulenko V. V. Basina Areg A. Totolian
author_sort	N. A. Arsentieva
title	CXCR3 CHEMOKINE RECEPTOR EXPRESSION ON PERIPHERAL BLOOD B-CELL SUBSETS IN PATIENTS WITH CHRONIC HEPATITIS C
title_short	CXCR3 CHEMOKINE RECEPTOR EXPRESSION ON PERIPHERAL BLOOD B-CELL SUBSETS IN PATIENTS WITH CHRONIC HEPATITIS C
title_full	CXCR3 CHEMOKINE RECEPTOR EXPRESSION ON PERIPHERAL BLOOD B-CELL SUBSETS IN PATIENTS WITH CHRONIC HEPATITIS C
title_fullStr	CXCR3 CHEMOKINE RECEPTOR EXPRESSION ON PERIPHERAL BLOOD B-CELL SUBSETS IN PATIENTS WITH CHRONIC HEPATITIS C
title_full_unstemmed	CXCR3 CHEMOKINE RECEPTOR EXPRESSION ON PERIPHERAL BLOOD B-CELL SUBSETS IN PATIENTS WITH CHRONIC HEPATITIS C
title_sort	cxcr3 chemokine receptor expression on peripheral blood b-cell subsets in patients with chronic hepatitis c
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/cacc551d027b4fc99a5a77b03f4a78c8
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CXCR3 CHEMOKINE RECEPTOR EXPRESSION ON PERIPHERAL BLOOD B-CELL SUBSETS IN PATIENTS WITH CHRONIC HEPATITIS C

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