Mesenchymal Stromal Cells Modulate Corneal Alloimmunity via Secretion of Hepatocyte Growth Factor

Abstract Mesenchymal stromal cells (MSCs) are multipotent stem cells that participate in tissue repair and possess considerable immunomodulatory potential. MSCs have been shown to promote allograft survival, yet the mechanisms behind this phenomenon have not been fully defined. Here, we investigate...

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Autores principales:	Sharad K. Mittal, William Foulsham, Sachin Shukla, Elsayed Elbasiony, Masahiro Omoto, Sunil K. Chauhan
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2019
Materias:	Cornea Transplantation Mesenchymal stromal cells Hepatocyte growth factor Medicine (General) R5-920 Cytology QH573-671
Acceso en línea:	https://doaj.org/article/cacc75198e384647935177e5aa3be9be
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spelling	oai:doaj.org-article:cacc75198e384647935177e5aa3be9be2021-11-30T19:15:37ZMesenchymal Stromal Cells Modulate Corneal Alloimmunity via Secretion of Hepatocyte Growth Factor2157-65802157-656410.1002/sctm.19-0004https://doaj.org/article/cacc75198e384647935177e5aa3be9be2019-10-01T00:00:00Zhttps://doi.org/10.1002/sctm.19-0004https://doaj.org/toc/2157-6564https://doaj.org/toc/2157-6580Abstract Mesenchymal stromal cells (MSCs) are multipotent stem cells that participate in tissue repair and possess considerable immunomodulatory potential. MSCs have been shown to promote allograft survival, yet the mechanisms behind this phenomenon have not been fully defined. Here, we investigate the capacity of MSCs to suppress the allogeneic immune response by secreting the pleiotropic molecule hepatocyte growth factor (HGF). Using an in vivo mouse model of corneal transplantation, we report that MSCs promote graft survival in an HGF‐dependent manner. Moreover, our data indicate that topically administered recombinant HGF (a) suppresses antigen‐presenting cell maturation in draining lymphoid tissue, (b) limits T‐helper type‐1 cell generation, (c) decreases inflammatory cell infiltration into grafted tissue, and (d) is itself sufficient to promote transplant survival. These findings have potential translational implications for the development of HGF‐based therapeutics. Stem Cells Translational Medicine 2019;8:1030–1040Sharad K. MittalWilliam FoulshamSachin ShuklaElsayed ElbasionyMasahiro OmotoSunil K. ChauhanWileyarticleCorneaTransplantationMesenchymal stromal cellsHepatocyte growth factorMedicine (General)R5-920CytologyQH573-671ENStem Cells Translational Medicine, Vol 8, Iss 10, Pp 1030-1040 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cornea Transplantation Mesenchymal stromal cells Hepatocyte growth factor Medicine (General) R5-920 Cytology QH573-671
spellingShingle	Cornea Transplantation Mesenchymal stromal cells Hepatocyte growth factor Medicine (General) R5-920 Cytology QH573-671 Sharad K. Mittal William Foulsham Sachin Shukla Elsayed Elbasiony Masahiro Omoto Sunil K. Chauhan Mesenchymal Stromal Cells Modulate Corneal Alloimmunity via Secretion of Hepatocyte Growth Factor
description	Abstract Mesenchymal stromal cells (MSCs) are multipotent stem cells that participate in tissue repair and possess considerable immunomodulatory potential. MSCs have been shown to promote allograft survival, yet the mechanisms behind this phenomenon have not been fully defined. Here, we investigate the capacity of MSCs to suppress the allogeneic immune response by secreting the pleiotropic molecule hepatocyte growth factor (HGF). Using an in vivo mouse model of corneal transplantation, we report that MSCs promote graft survival in an HGF‐dependent manner. Moreover, our data indicate that topically administered recombinant HGF (a) suppresses antigen‐presenting cell maturation in draining lymphoid tissue, (b) limits T‐helper type‐1 cell generation, (c) decreases inflammatory cell infiltration into grafted tissue, and (d) is itself sufficient to promote transplant survival. These findings have potential translational implications for the development of HGF‐based therapeutics. Stem Cells Translational Medicine 2019;8:1030–1040
format	article
author	Sharad K. Mittal William Foulsham Sachin Shukla Elsayed Elbasiony Masahiro Omoto Sunil K. Chauhan
author_facet	Sharad K. Mittal William Foulsham Sachin Shukla Elsayed Elbasiony Masahiro Omoto Sunil K. Chauhan
author_sort	Sharad K. Mittal
title	Mesenchymal Stromal Cells Modulate Corneal Alloimmunity via Secretion of Hepatocyte Growth Factor
title_short	Mesenchymal Stromal Cells Modulate Corneal Alloimmunity via Secretion of Hepatocyte Growth Factor
title_full	Mesenchymal Stromal Cells Modulate Corneal Alloimmunity via Secretion of Hepatocyte Growth Factor
title_fullStr	Mesenchymal Stromal Cells Modulate Corneal Alloimmunity via Secretion of Hepatocyte Growth Factor
title_full_unstemmed	Mesenchymal Stromal Cells Modulate Corneal Alloimmunity via Secretion of Hepatocyte Growth Factor
title_sort	mesenchymal stromal cells modulate corneal alloimmunity via secretion of hepatocyte growth factor
publisher	Wiley
publishDate	2019
url	https://doaj.org/article/cacc75198e384647935177e5aa3be9be
work_keys_str_mv	AT sharadkmittal mesenchymalstromalcellsmodulatecornealalloimmunityviasecretionofhepatocytegrowthfactor AT williamfoulsham mesenchymalstromalcellsmodulatecornealalloimmunityviasecretionofhepatocytegrowthfactor AT sachinshukla mesenchymalstromalcellsmodulatecornealalloimmunityviasecretionofhepatocytegrowthfactor AT elsayedelbasiony mesenchymalstromalcellsmodulatecornealalloimmunityviasecretionofhepatocytegrowthfactor AT masahiroomoto mesenchymalstromalcellsmodulatecornealalloimmunityviasecretionofhepatocytegrowthfactor AT sunilkchauhan mesenchymalstromalcellsmodulatecornealalloimmunityviasecretionofhepatocytegrowthfactor
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Mesenchymal Stromal Cells Modulate Corneal Alloimmunity via Secretion of Hepatocyte Growth Factor

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