The role of family history of Cancer in Oral Cavity Cancer

Abstract Objectives Oral and oropharyngeal squamous cell carcinoma (SCC) is the 10th most common cancer in the United States (8th in males, 13th in females), with an estimated 54,010 new cases expected in 2021, and is primarily associated with smoked tobacco, heavy alcohol consumption, areca nut use...

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Autores principales:	Paolo Junior Fantozzi, Roxanne Bavarian, Ibon Tamayo, Marie-Abele Bind, Sook-Bin Woo, Alessandro Villa
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Oral cancer Oral cavity Risk factors Family history Immunosuppression Cancer Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/cad2c6ae183046eabe025c080aae9d50
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spelling	oai:doaj.org-article:cad2c6ae183046eabe025c080aae9d502021-11-28T12:09:58ZThe role of family history of Cancer in Oral Cavity Cancer10.1186/s13005-021-00298-81746-160Xhttps://doaj.org/article/cad2c6ae183046eabe025c080aae9d502021-11-01T00:00:00Zhttps://doi.org/10.1186/s13005-021-00298-8https://doaj.org/toc/1746-160XAbstract Objectives Oral and oropharyngeal squamous cell carcinoma (SCC) is the 10th most common cancer in the United States (8th in males, 13th in females), with an estimated 54,010 new cases expected in 2021, and is primarily associated with smoked tobacco, heavy alcohol consumption, areca nut use and persistent high-risk human papillomavirus (HPV). Family history of cancer (FHC) and family history of head and neck cancer (FHHNC) have been reported to play an important role in the development of OSCC. We aimed to investigate the role of FHC, FHHNC and personal history of cancer in first/second degree-relatives as co-risk factors for oral cancer. Methods This was a retrospective study of patients diagnosed with OSCC at the Division of Oral Medicine and Dentistry at Brigham and Women’s Hospital and at the Division of Head and Neck Oncology at Dana Farber Cancer Institute. Conditional logistic regressions were performed to examine whether OSCC was associated with FHC and FHHNC of FDRs and SDRs, personal history of cancer and secondary risk factors. Results Overall, we did not find an association between FHC, FHHNC and OSCC risk, whereas patients with a cancer history in one of their siblings were 1.6-times more likely to present with an OSCC. When secondary risk factors were considered, patients with a history of oral leukoplakia and dysplasia had a 16-times higher risk of having an OSCC. Conclusions Our study confirmed that a previous history of oral leukoplakia or dysplasia was an independent risk factor for OSCC. A positive family history of cancer in one or more siblings may be an additional risk factor for OSCC.Paolo Junior FantozziRoxanne BavarianIbon TamayoMarie-Abele BindSook-Bin WooAlessandro VillaBMCarticleOral cancerOral cavityRisk factorsFamily historyImmunosuppressionCancerSpecialties of internal medicineRC581-951ENHead & Face Medicine, Vol 17, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Oral cancer Oral cavity Risk factors Family history Immunosuppression Cancer Specialties of internal medicine RC581-951
spellingShingle	Oral cancer Oral cavity Risk factors Family history Immunosuppression Cancer Specialties of internal medicine RC581-951 Paolo Junior Fantozzi Roxanne Bavarian Ibon Tamayo Marie-Abele Bind Sook-Bin Woo Alessandro Villa The role of family history of Cancer in Oral Cavity Cancer
description	Abstract Objectives Oral and oropharyngeal squamous cell carcinoma (SCC) is the 10th most common cancer in the United States (8th in males, 13th in females), with an estimated 54,010 new cases expected in 2021, and is primarily associated with smoked tobacco, heavy alcohol consumption, areca nut use and persistent high-risk human papillomavirus (HPV). Family history of cancer (FHC) and family history of head and neck cancer (FHHNC) have been reported to play an important role in the development of OSCC. We aimed to investigate the role of FHC, FHHNC and personal history of cancer in first/second degree-relatives as co-risk factors for oral cancer. Methods This was a retrospective study of patients diagnosed with OSCC at the Division of Oral Medicine and Dentistry at Brigham and Women’s Hospital and at the Division of Head and Neck Oncology at Dana Farber Cancer Institute. Conditional logistic regressions were performed to examine whether OSCC was associated with FHC and FHHNC of FDRs and SDRs, personal history of cancer and secondary risk factors. Results Overall, we did not find an association between FHC, FHHNC and OSCC risk, whereas patients with a cancer history in one of their siblings were 1.6-times more likely to present with an OSCC. When secondary risk factors were considered, patients with a history of oral leukoplakia and dysplasia had a 16-times higher risk of having an OSCC. Conclusions Our study confirmed that a previous history of oral leukoplakia or dysplasia was an independent risk factor for OSCC. A positive family history of cancer in one or more siblings may be an additional risk factor for OSCC.
format	article
author	Paolo Junior Fantozzi Roxanne Bavarian Ibon Tamayo Marie-Abele Bind Sook-Bin Woo Alessandro Villa
author_facet	Paolo Junior Fantozzi Roxanne Bavarian Ibon Tamayo Marie-Abele Bind Sook-Bin Woo Alessandro Villa
author_sort	Paolo Junior Fantozzi
title	The role of family history of Cancer in Oral Cavity Cancer
title_short	The role of family history of Cancer in Oral Cavity Cancer
title_full	The role of family history of Cancer in Oral Cavity Cancer
title_fullStr	The role of family history of Cancer in Oral Cavity Cancer
title_full_unstemmed	The role of family history of Cancer in Oral Cavity Cancer
title_sort	role of family history of cancer in oral cavity cancer
publisher	BMC
publishDate	2021
url	https://doaj.org/article/cad2c6ae183046eabe025c080aae9d50
work_keys_str_mv	AT paolojuniorfantozzi theroleoffamilyhistoryofcancerinoralcavitycancer AT roxannebavarian theroleoffamilyhistoryofcancerinoralcavitycancer AT ibontamayo theroleoffamilyhistoryofcancerinoralcavitycancer AT marieabelebind theroleoffamilyhistoryofcancerinoralcavitycancer AT sookbinwoo theroleoffamilyhistoryofcancerinoralcavitycancer AT alessandrovilla theroleoffamilyhistoryofcancerinoralcavitycancer AT paolojuniorfantozzi roleoffamilyhistoryofcancerinoralcavitycancer AT roxannebavarian roleoffamilyhistoryofcancerinoralcavitycancer AT ibontamayo roleoffamilyhistoryofcancerinoralcavitycancer AT marieabelebind roleoffamilyhistoryofcancerinoralcavitycancer AT sookbinwoo roleoffamilyhistoryofcancerinoralcavitycancer AT alessandrovilla roleoffamilyhistoryofcancerinoralcavitycancer
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The role of family history of Cancer in Oral Cavity Cancer

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