Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans

Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans

Lung cancer etiology has largely been studied in homogenous populations of European descent. Here, targeted sequencing in African American lung adenocarcinomas finds significantly higher prevalence of PTPRTand JAK2 mutations, validated independently by whole exome sequencing, highlighting potentiall...

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Autores principales: Khadijah A. Mitchell, Noah Nichols, Wei Tang, Jennifer Walling, Holly Stevenson, Marbin Pineda, Roxana Stefanescu, Daniel C. Edelman, Andrew T. Girvin, Adriana Zingone, Sanju Sinha, Elise Bowman, Emily L. Rossi, Rony F. Arauz, Yuelin Jack Zhu, Justin Lack, Elizabeth Weingartner, Joshua J. Waterfall, Sharon R. Pine, John Simmons, Paul Meltzer, Bríd M. Ryan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/cad556f170ba4c32bd112c041c7993c8
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Sumario:Lung cancer etiology has largely been studied in homogenous populations of European descent. Here, targeted sequencing in African American lung adenocarcinomas finds significantly higher prevalence of PTPRTand JAK2 mutations, validated independently by whole exome sequencing, highlighting potentially clinically actionable mutations in this population.

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