Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans

Lung cancer etiology has largely been studied in homogenous populations of European descent. Here, targeted sequencing in African American lung adenocarcinomas finds significantly higher prevalence of PTPRTand JAK2 mutations, validated independently by whole exome sequencing, highlighting potentiall...

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Autores principales:	Khadijah A. Mitchell, Noah Nichols, Wei Tang, Jennifer Walling, Holly Stevenson, Marbin Pineda, Roxana Stefanescu, Daniel C. Edelman, Andrew T. Girvin, Adriana Zingone, Sanju Sinha, Elise Bowman, Emily L. Rossi, Rony F. Arauz, Yuelin Jack Zhu, Justin Lack, Elizabeth Weingartner, Joshua J. Waterfall, Sharon R. Pine, John Simmons, Paul Meltzer, Bríd M. Ryan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cad556f170ba4c32bd112c041c7993c8
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spelling	oai:doaj.org-article:cad556f170ba4c32bd112c041c7993c82021-12-02T14:39:01ZRecurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans10.1038/s41467-019-13732-y2041-1723https://doaj.org/article/cad556f170ba4c32bd112c041c7993c82019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13732-yhttps://doaj.org/toc/2041-1723Lung cancer etiology has largely been studied in homogenous populations of European descent. Here, targeted sequencing in African American lung adenocarcinomas finds significantly higher prevalence of PTPRTand JAK2 mutations, validated independently by whole exome sequencing, highlighting potentially clinically actionable mutations in this population.Khadijah A. MitchellNoah NicholsWei TangJennifer WallingHolly StevensonMarbin PinedaRoxana StefanescuDaniel C. EdelmanAndrew T. GirvinAdriana ZingoneSanju SinhaElise BowmanEmily L. RossiRony F. ArauzYuelin Jack ZhuJustin LackElizabeth WeingartnerJoshua J. WaterfallSharon R. PineJohn SimmonsPaul MeltzerBríd M. RyanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Khadijah A. Mitchell Noah Nichols Wei Tang Jennifer Walling Holly Stevenson Marbin Pineda Roxana Stefanescu Daniel C. Edelman Andrew T. Girvin Adriana Zingone Sanju Sinha Elise Bowman Emily L. Rossi Rony F. Arauz Yuelin Jack Zhu Justin Lack Elizabeth Weingartner Joshua J. Waterfall Sharon R. Pine John Simmons Paul Meltzer Bríd M. Ryan Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans
description	Lung cancer etiology has largely been studied in homogenous populations of European descent. Here, targeted sequencing in African American lung adenocarcinomas finds significantly higher prevalence of PTPRTand JAK2 mutations, validated independently by whole exome sequencing, highlighting potentially clinically actionable mutations in this population.
format	article
author	Khadijah A. Mitchell Noah Nichols Wei Tang Jennifer Walling Holly Stevenson Marbin Pineda Roxana Stefanescu Daniel C. Edelman Andrew T. Girvin Adriana Zingone Sanju Sinha Elise Bowman Emily L. Rossi Rony F. Arauz Yuelin Jack Zhu Justin Lack Elizabeth Weingartner Joshua J. Waterfall Sharon R. Pine John Simmons Paul Meltzer Bríd M. Ryan
author_facet	Khadijah A. Mitchell Noah Nichols Wei Tang Jennifer Walling Holly Stevenson Marbin Pineda Roxana Stefanescu Daniel C. Edelman Andrew T. Girvin Adriana Zingone Sanju Sinha Elise Bowman Emily L. Rossi Rony F. Arauz Yuelin Jack Zhu Justin Lack Elizabeth Weingartner Joshua J. Waterfall Sharon R. Pine John Simmons Paul Meltzer Bríd M. Ryan
author_sort	Khadijah A. Mitchell
title	Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans
title_short	Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans
title_full	Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans
title_fullStr	Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans
title_full_unstemmed	Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans
title_sort	recurrent ptprt/jak2 mutations in lung adenocarcinoma among african americans
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/cad556f170ba4c32bd112c041c7993c8
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Recurrent PTPRT/JAK2 mutations in lung adenocarcinoma among African Americans

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