Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors

Bleeding complications limits the use of effective antithrombotics therapeutics. Here, the authors developed next-generation direct thrombin inhibitors with low bleeding risks as safe peri-percutaneous coronary intervention anticoagulants when used in combination with antiplatelets.

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Autores principales:	Cho Yeow Koh, Norrapat Shih, Christina Y. C. Yip, Aaron Wei Liang Li, Weiming Chen, Fathiah S. Amran, Esther Jia En Leong, Janaki Krishnamoorthy Iyer, Grace Croft, Muhammad Ibrahim Bin Mazlan, Yen-Lin Chee, Eng-Soo Yap, Dougald M. Monroe, Maureane Hoffman, Richard C. Becker, Dominique P. V. de Kleijn, Vaishali Verma, Amita Gupta, Vijay K. Chaudhary, A. Mark Richards, R. Manjunatha Kini, Mark Y. Chan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cad6e99b695d4c66a9002c62027f15b1
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spelling	oai:doaj.org-article:cad6e99b695d4c66a9002c62027f15b12021-11-28T12:35:50ZEfficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors10.1038/s41467-021-27275-82041-1723https://doaj.org/article/cad6e99b695d4c66a9002c62027f15b12021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27275-8https://doaj.org/toc/2041-1723Bleeding complications limits the use of effective antithrombotics therapeutics. Here, the authors developed next-generation direct thrombin inhibitors with low bleeding risks as safe peri-percutaneous coronary intervention anticoagulants when used in combination with antiplatelets.Cho Yeow KohNorrapat ShihChristina Y. C. YipAaron Wei Liang LiWeiming ChenFathiah S. AmranEsther Jia En LeongJanaki Krishnamoorthy IyerGrace CroftMuhammad Ibrahim Bin MazlanYen-Lin CheeEng-Soo YapDougald M. MonroeMaureane HoffmanRichard C. BeckerDominique P. V. de KleijnVaishali VermaAmita GuptaVijay K. ChaudharyA. Mark RichardsR. Manjunatha KiniMark Y. ChanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cho Yeow Koh Norrapat Shih Christina Y. C. Yip Aaron Wei Liang Li Weiming Chen Fathiah S. Amran Esther Jia En Leong Janaki Krishnamoorthy Iyer Grace Croft Muhammad Ibrahim Bin Mazlan Yen-Lin Chee Eng-Soo Yap Dougald M. Monroe Maureane Hoffman Richard C. Becker Dominique P. V. de Kleijn Vaishali Verma Amita Gupta Vijay K. Chaudhary A. Mark Richards R. Manjunatha Kini Mark Y. Chan Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors
description	Bleeding complications limits the use of effective antithrombotics therapeutics. Here, the authors developed next-generation direct thrombin inhibitors with low bleeding risks as safe peri-percutaneous coronary intervention anticoagulants when used in combination with antiplatelets.
format	article
author	Cho Yeow Koh Norrapat Shih Christina Y. C. Yip Aaron Wei Liang Li Weiming Chen Fathiah S. Amran Esther Jia En Leong Janaki Krishnamoorthy Iyer Grace Croft Muhammad Ibrahim Bin Mazlan Yen-Lin Chee Eng-Soo Yap Dougald M. Monroe Maureane Hoffman Richard C. Becker Dominique P. V. de Kleijn Vaishali Verma Amita Gupta Vijay K. Chaudhary A. Mark Richards R. Manjunatha Kini Mark Y. Chan
author_facet	Cho Yeow Koh Norrapat Shih Christina Y. C. Yip Aaron Wei Liang Li Weiming Chen Fathiah S. Amran Esther Jia En Leong Janaki Krishnamoorthy Iyer Grace Croft Muhammad Ibrahim Bin Mazlan Yen-Lin Chee Eng-Soo Yap Dougald M. Monroe Maureane Hoffman Richard C. Becker Dominique P. V. de Kleijn Vaishali Verma Amita Gupta Vijay K. Chaudhary A. Mark Richards R. Manjunatha Kini Mark Y. Chan
author_sort	Cho Yeow Koh
title	Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors
title_short	Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors
title_full	Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors
title_fullStr	Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors
title_full_unstemmed	Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors
title_sort	efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cad6e99b695d4c66a9002c62027f15b1
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Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors

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