A general theoretical framework to design base editors with reduced bystander effects

Base editors can edit target nucleotides, and identical ones that are within the editing window. Here the authors build an analytical model to propose general principles of editor design to reduce bystander effects.

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Autores principales:	Qian Wang, Jie Yang, Zhicheng Zhong, Jeffrey A. Vanegas, Xue Gao, Anatoly B. Kolomeisky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cad9f9a2161f45c0a9f734f112a85fde
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spelling	oai:doaj.org-article:cad9f9a2161f45c0a9f734f112a85fde2021-11-14T12:36:22ZA general theoretical framework to design base editors with reduced bystander effects10.1038/s41467-021-26789-52041-1723https://doaj.org/article/cad9f9a2161f45c0a9f734f112a85fde2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26789-5https://doaj.org/toc/2041-1723Base editors can edit target nucleotides, and identical ones that are within the editing window. Here the authors build an analytical model to propose general principles of editor design to reduce bystander effects.Qian WangJie YangZhicheng ZhongJeffrey A. VanegasXue GaoAnatoly B. KolomeiskyNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qian Wang Jie Yang Zhicheng Zhong Jeffrey A. Vanegas Xue Gao Anatoly B. Kolomeisky A general theoretical framework to design base editors with reduced bystander effects
description	Base editors can edit target nucleotides, and identical ones that are within the editing window. Here the authors build an analytical model to propose general principles of editor design to reduce bystander effects.
format	article
author	Qian Wang Jie Yang Zhicheng Zhong Jeffrey A. Vanegas Xue Gao Anatoly B. Kolomeisky
author_facet	Qian Wang Jie Yang Zhicheng Zhong Jeffrey A. Vanegas Xue Gao Anatoly B. Kolomeisky
author_sort	Qian Wang
title	A general theoretical framework to design base editors with reduced bystander effects
title_short	A general theoretical framework to design base editors with reduced bystander effects
title_full	A general theoretical framework to design base editors with reduced bystander effects
title_fullStr	A general theoretical framework to design base editors with reduced bystander effects
title_full_unstemmed	A general theoretical framework to design base editors with reduced bystander effects
title_sort	general theoretical framework to design base editors with reduced bystander effects
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cad9f9a2161f45c0a9f734f112a85fde
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A general theoretical framework to design base editors with reduced bystander effects

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