Overtraining Strengthens the Visual Discrimination Memory Trace Outside the Hippocampus in Male Rats

The hippocampus (HPC) may compete with other memory systems when establishing a representation, a process termed overshadowing. However, this overshadowing may be mitigated by repeated learning episodes, making a memory resistant to post-training hippocampal damage. In the current study, we examined...

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Autores principales:	Hugo Lehmann, Morgan G. Stykel, Melissa J. Glenn
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	retrograde amnesia lesion consolidation hippocampus rat Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/cadc8eab392e4d1e917fcf9986ec401a
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id	oai:doaj.org-article:cadc8eab392e4d1e917fcf9986ec401a
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spelling	oai:doaj.org-article:cadc8eab392e4d1e917fcf9986ec401a2021-11-15T06:34:40ZOvertraining Strengthens the Visual Discrimination Memory Trace Outside the Hippocampus in Male Rats1662-515310.3389/fnbeh.2021.768552https://doaj.org/article/cadc8eab392e4d1e917fcf9986ec401a2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnbeh.2021.768552/fullhttps://doaj.org/toc/1662-5153The hippocampus (HPC) may compete with other memory systems when establishing a representation, a process termed overshadowing. However, this overshadowing may be mitigated by repeated learning episodes, making a memory resistant to post-training hippocampal damage. In the current study, we examined this overshadowing process for a hippocampal-dependent visual discrimination memory in rats. In Experiment 1, male rats were trained to criterion (80% accuracy on two consecutive days) on a visual discrimination and then given 50 additional trials distributed over 5 days or 10 weeks. Regardless of this additional learning, extensive damage to the HPC caused retrograde amnesia for the visual discrimination, suggesting that the memory remained hippocampal-dependent. In Experiment 2, rats received hippocampal damage before learning and required approximately twice as many trials to acquire the visual discrimination as control rats, suggesting that, when the overshadowing or competition is removed, the non-hippocampal memory systems only slowly acquires the discrimination. In Experiment 3, increasing the additional learning beyond criterion by 230 trials, the amount needed in Experiment 2 to train the non-hippocampal systems in absence of competition, successfully prevented the retrograde amnesic effects of post-training hippocampal damage. Combined, the findings suggest that a visual discrimination memory trace can be strengthened in non-hippocampal systems with overtraining and become independent of the HPC.Hugo LehmannMorgan G. StykelMelissa J. GlennFrontiers Media S.A.articleretrograde amnesialesionconsolidationhippocampusratNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Behavioral Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	retrograde amnesia lesion consolidation hippocampus rat Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	retrograde amnesia lesion consolidation hippocampus rat Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Hugo Lehmann Morgan G. Stykel Melissa J. Glenn Overtraining Strengthens the Visual Discrimination Memory Trace Outside the Hippocampus in Male Rats
description	The hippocampus (HPC) may compete with other memory systems when establishing a representation, a process termed overshadowing. However, this overshadowing may be mitigated by repeated learning episodes, making a memory resistant to post-training hippocampal damage. In the current study, we examined this overshadowing process for a hippocampal-dependent visual discrimination memory in rats. In Experiment 1, male rats were trained to criterion (80% accuracy on two consecutive days) on a visual discrimination and then given 50 additional trials distributed over 5 days or 10 weeks. Regardless of this additional learning, extensive damage to the HPC caused retrograde amnesia for the visual discrimination, suggesting that the memory remained hippocampal-dependent. In Experiment 2, rats received hippocampal damage before learning and required approximately twice as many trials to acquire the visual discrimination as control rats, suggesting that, when the overshadowing or competition is removed, the non-hippocampal memory systems only slowly acquires the discrimination. In Experiment 3, increasing the additional learning beyond criterion by 230 trials, the amount needed in Experiment 2 to train the non-hippocampal systems in absence of competition, successfully prevented the retrograde amnesic effects of post-training hippocampal damage. Combined, the findings suggest that a visual discrimination memory trace can be strengthened in non-hippocampal systems with overtraining and become independent of the HPC.
format	article
author	Hugo Lehmann Morgan G. Stykel Melissa J. Glenn
author_facet	Hugo Lehmann Morgan G. Stykel Melissa J. Glenn
author_sort	Hugo Lehmann
title	Overtraining Strengthens the Visual Discrimination Memory Trace Outside the Hippocampus in Male Rats
title_short	Overtraining Strengthens the Visual Discrimination Memory Trace Outside the Hippocampus in Male Rats
title_full	Overtraining Strengthens the Visual Discrimination Memory Trace Outside the Hippocampus in Male Rats
title_fullStr	Overtraining Strengthens the Visual Discrimination Memory Trace Outside the Hippocampus in Male Rats
title_full_unstemmed	Overtraining Strengthens the Visual Discrimination Memory Trace Outside the Hippocampus in Male Rats
title_sort	overtraining strengthens the visual discrimination memory trace outside the hippocampus in male rats
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/cadc8eab392e4d1e917fcf9986ec401a
work_keys_str_mv	AT hugolehmann overtrainingstrengthensthevisualdiscriminationmemorytraceoutsidethehippocampusinmalerats AT morgangstykel overtrainingstrengthensthevisualdiscriminationmemorytraceoutsidethehippocampusinmalerats AT melissajglenn overtrainingstrengthensthevisualdiscriminationmemorytraceoutsidethehippocampusinmalerats
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Overtraining Strengthens the Visual Discrimination Memory Trace Outside the Hippocampus in Male Rats

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