FACTORS OF THE ACUTE PHASE OF INFLAMMATION AS MODULATORS OF THE INTERACTION OF MAST CELLS AND FIBROBLASTS

We investigated the influence of factors of the acute phase of inflammation (purified anaphylatoxins C3a and C5a, pentraxin C-reactive protein (CRP), and aggregated. IgG (aIgG) — as an analogue of circulating immune complexes) on the adhesive interaction of human mast cells (MC) with human fibroblas...

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Autores principales:	S. A. Trulioff, I. V. Kudryavtsev, P. G. Nazarov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	anaphylatoxins c-reactive protein mast cells fibroblasts Science Q
Acceso en línea:	https://doaj.org/article/cadca21efc72468a9a47f82b921dd2d0
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spelling	oai:doaj.org-article:cadca21efc72468a9a47f82b921dd2d02021-11-23T06:14:20ZFACTORS OF THE ACUTE PHASE OF INFLAMMATION AS MODULATORS OF THE INTERACTION OF MAST CELLS AND FIBROBLASTS2541-94202587-9596https://doaj.org/article/cadca21efc72468a9a47f82b921dd2d02012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/944https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596We investigated the influence of factors of the acute phase of inflammation (purified anaphylatoxins C3a and C5a, pentraxin C-reactive protein (CRP), and aggregated. IgG (aIgG) — as an analogue of circulating immune complexes) on the adhesive interaction of human mast cells (MC) with human fibroblasts (FB). HMC-1 MC line and primary human foreskin FB were used. MC or FB were treated with each of the studied inflammatory proteins within 24 h and then the changes in their adhesive properties were examined. Cell adhesion was assessed by flow cytometry. The results showed that all studied proteins increased MC adhesiveness, whereas FB adhesiveness was increased only by anaphylatoxins. Stimulation of the adhesive properties of the MC was associated with increased expression of CD11b and ICAM-1 molecules.S. A. TrulioffI. V. KudryavtsevP. G. NazarovScientific Сentre for Family Health and Human Reproduction Problemsarticleanaphylatoxinsc-reactive proteinmast cellsfibroblastsScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 319-322 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	anaphylatoxins c-reactive protein mast cells fibroblasts Science Q
spellingShingle	anaphylatoxins c-reactive protein mast cells fibroblasts Science Q S. A. Trulioff I. V. Kudryavtsev P. G. Nazarov FACTORS OF THE ACUTE PHASE OF INFLAMMATION AS MODULATORS OF THE INTERACTION OF MAST CELLS AND FIBROBLASTS
description	We investigated the influence of factors of the acute phase of inflammation (purified anaphylatoxins C3a and C5a, pentraxin C-reactive protein (CRP), and aggregated. IgG (aIgG) — as an analogue of circulating immune complexes) on the adhesive interaction of human mast cells (MC) with human fibroblasts (FB). HMC-1 MC line and primary human foreskin FB were used. MC or FB were treated with each of the studied inflammatory proteins within 24 h and then the changes in their adhesive properties were examined. Cell adhesion was assessed by flow cytometry. The results showed that all studied proteins increased MC adhesiveness, whereas FB adhesiveness was increased only by anaphylatoxins. Stimulation of the adhesive properties of the MC was associated with increased expression of CD11b and ICAM-1 molecules.
format	article
author	S. A. Trulioff I. V. Kudryavtsev P. G. Nazarov
author_facet	S. A. Trulioff I. V. Kudryavtsev P. G. Nazarov
author_sort	S. A. Trulioff
title	FACTORS OF THE ACUTE PHASE OF INFLAMMATION AS MODULATORS OF THE INTERACTION OF MAST CELLS AND FIBROBLASTS
title_short	FACTORS OF THE ACUTE PHASE OF INFLAMMATION AS MODULATORS OF THE INTERACTION OF MAST CELLS AND FIBROBLASTS
title_full	FACTORS OF THE ACUTE PHASE OF INFLAMMATION AS MODULATORS OF THE INTERACTION OF MAST CELLS AND FIBROBLASTS
title_fullStr	FACTORS OF THE ACUTE PHASE OF INFLAMMATION AS MODULATORS OF THE INTERACTION OF MAST CELLS AND FIBROBLASTS
title_full_unstemmed	FACTORS OF THE ACUTE PHASE OF INFLAMMATION AS MODULATORS OF THE INTERACTION OF MAST CELLS AND FIBROBLASTS
title_sort	factors of the acute phase of inflammation as modulators of the interaction of mast cells and fibroblasts
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/cadca21efc72468a9a47f82b921dd2d0
work_keys_str_mv	AT satrulioff factorsoftheacutephaseofinflammationasmodulatorsoftheinteractionofmastcellsandfibroblasts AT ivkudryavtsev factorsoftheacutephaseofinflammationasmodulatorsoftheinteractionofmastcellsandfibroblasts AT pgnazarov factorsoftheacutephaseofinflammationasmodulatorsoftheinteractionofmastcellsandfibroblasts
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FACTORS OF THE ACUTE PHASE OF INFLAMMATION AS MODULATORS OF THE INTERACTION OF MAST CELLS AND FIBROBLASTS

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