Clinical significance of small molecule metabolites in the blood of patients with different types of liver injury

Abstract To understand the characteristic of changes of serum metabolites between healthy people and patients with hepatitis B virus (HBV) infection at different stages of disease, and to provide reference metabolomics information for clinical diagnosis of liver disease patients. 255 patients with d...

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Autores principales:	Hui Li, Yan Wang, Shizhao Ma, Chaoqun Zhang, Hua Liu, Dianxing Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cade4ab836244dad83fb55c0b7f9aa8f
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spelling	oai:doaj.org-article:cade4ab836244dad83fb55c0b7f9aa8f2021-12-02T15:56:49ZClinical significance of small molecule metabolites in the blood of patients with different types of liver injury10.1038/s41598-021-91164-92045-2322https://doaj.org/article/cade4ab836244dad83fb55c0b7f9aa8f2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91164-9https://doaj.org/toc/2045-2322Abstract To understand the characteristic of changes of serum metabolites between healthy people and patients with hepatitis B virus (HBV) infection at different stages of disease, and to provide reference metabolomics information for clinical diagnosis of liver disease patients. 255 patients with different stages of HBV infection were selected. 3 mL blood was collected from each patient in the morning to detect differences in serum lysophosphatidylcholine, acetyl-l-carnitine, oleic acid amide, and glycocholic acid concentrations by UFLC-IT-TOF/MS. The diagnostic values of four metabolic substances were evaluated by receiver operating characteristic (ROC) curve. The results showed that the optimal cut-off value of oleic acid amide concentration of the liver cirrhosis and HCC groups was 23.6 mg/L, with a diagnostic sensitivity of 88.9% and specificity of 70.6%. The diagnostic efficacies of the three substances were similar in the hepatitis and HCC groups, with an optimal cut-off value of 2.04 mg/L, and a diagnostic sensitivity and specificity of 100% and 47.2%, respectively. The optimal cut-off value of lecithin of the HBV-carrier and HCC groups was 132.85 mg/L, with a diagnostic sensitivity and specificity of 88.9% and 66.7%, respectively. The optimal cut-off value of oleic acid amide of the healthy and HCC groups was 129.03 mg/L, with a diagnostic sensitivity and specificity of 88.4% and 83.3%, respectively. Lysophosphatidylcholine, acetyl-l-carnitine, and oleic acid amide were potential metabolic markers of HCC. Among them, lysophosphatidylcholine was low in the blood of HCC patients, and its diagnostic efficacy was better than that of acetyl-l-carnitine and oleic acid amide, providing reference metabolomics information in clinical diagnosis and future research.Hui LiYan WangShizhao MaChaoqun ZhangHua LiuDianxing SunNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hui Li Yan Wang Shizhao Ma Chaoqun Zhang Hua Liu Dianxing Sun Clinical significance of small molecule metabolites in the blood of patients with different types of liver injury
description	Abstract To understand the characteristic of changes of serum metabolites between healthy people and patients with hepatitis B virus (HBV) infection at different stages of disease, and to provide reference metabolomics information for clinical diagnosis of liver disease patients. 255 patients with different stages of HBV infection were selected. 3 mL blood was collected from each patient in the morning to detect differences in serum lysophosphatidylcholine, acetyl-l-carnitine, oleic acid amide, and glycocholic acid concentrations by UFLC-IT-TOF/MS. The diagnostic values of four metabolic substances were evaluated by receiver operating characteristic (ROC) curve. The results showed that the optimal cut-off value of oleic acid amide concentration of the liver cirrhosis and HCC groups was 23.6 mg/L, with a diagnostic sensitivity of 88.9% and specificity of 70.6%. The diagnostic efficacies of the three substances were similar in the hepatitis and HCC groups, with an optimal cut-off value of 2.04 mg/L, and a diagnostic sensitivity and specificity of 100% and 47.2%, respectively. The optimal cut-off value of lecithin of the HBV-carrier and HCC groups was 132.85 mg/L, with a diagnostic sensitivity and specificity of 88.9% and 66.7%, respectively. The optimal cut-off value of oleic acid amide of the healthy and HCC groups was 129.03 mg/L, with a diagnostic sensitivity and specificity of 88.4% and 83.3%, respectively. Lysophosphatidylcholine, acetyl-l-carnitine, and oleic acid amide were potential metabolic markers of HCC. Among them, lysophosphatidylcholine was low in the blood of HCC patients, and its diagnostic efficacy was better than that of acetyl-l-carnitine and oleic acid amide, providing reference metabolomics information in clinical diagnosis and future research.
format	article
author	Hui Li Yan Wang Shizhao Ma Chaoqun Zhang Hua Liu Dianxing Sun
author_facet	Hui Li Yan Wang Shizhao Ma Chaoqun Zhang Hua Liu Dianxing Sun
author_sort	Hui Li
title	Clinical significance of small molecule metabolites in the blood of patients with different types of liver injury
title_short	Clinical significance of small molecule metabolites in the blood of patients with different types of liver injury
title_full	Clinical significance of small molecule metabolites in the blood of patients with different types of liver injury
title_fullStr	Clinical significance of small molecule metabolites in the blood of patients with different types of liver injury
title_full_unstemmed	Clinical significance of small molecule metabolites in the blood of patients with different types of liver injury
title_sort	clinical significance of small molecule metabolites in the blood of patients with different types of liver injury
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/cade4ab836244dad83fb55c0b7f9aa8f
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Clinical significance of small molecule metabolites in the blood of patients with different types of liver injury

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