Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease

Genetic variation can influence levels of disease-related plasma proteins and, thus, contribute to the pathogenesis of complex diseases. Here, the authors perform genome-wide QTL analysis for 71 plasma proteins to identify causal proteins for coronary heart disease and provide a molecular QTL browse...

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Autores principales:	Chen Yao, George Chen, Ci Song, Joshua Keefe, Michael Mendelson, Tianxiao Huan, Benjamin B. Sun, Annika Laser, Joseph C. Maranville, Hongsheng Wu, Jennifer E. Ho, Paul Courchesne, Asya Lyass, Martin G. Larson, Christian Gieger, Johannes Graumann, Andrew D. Johnson, John Danesh, Heiko Runz, Shih-Jen Hwang, Chunyu Liu, Adam S. Butterworth, Karsten Suhre, Daniel Levy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cae1352d0a9c4818b111c7a3955ca2ac
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spelling	oai:doaj.org-article:cae1352d0a9c4818b111c7a3955ca2ac2021-12-02T15:34:48ZGenome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease10.1038/s41467-018-05512-x2041-1723https://doaj.org/article/cae1352d0a9c4818b111c7a3955ca2ac2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05512-xhttps://doaj.org/toc/2041-1723Genetic variation can influence levels of disease-related plasma proteins and, thus, contribute to the pathogenesis of complex diseases. Here, the authors perform genome-wide QTL analysis for 71 plasma proteins to identify causal proteins for coronary heart disease and provide a molecular QTL browser.Chen YaoGeorge ChenCi SongJoshua KeefeMichael MendelsonTianxiao HuanBenjamin B. SunAnnika LaserJoseph C. MaranvilleHongsheng WuJennifer E. HoPaul CourchesneAsya LyassMartin G. LarsonChristian GiegerJohannes GraumannAndrew D. JohnsonJohn DaneshHeiko RunzShih-Jen HwangChunyu LiuAdam S. ButterworthKarsten SuhreDaniel LevyNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chen Yao George Chen Ci Song Joshua Keefe Michael Mendelson Tianxiao Huan Benjamin B. Sun Annika Laser Joseph C. Maranville Hongsheng Wu Jennifer E. Ho Paul Courchesne Asya Lyass Martin G. Larson Christian Gieger Johannes Graumann Andrew D. Johnson John Danesh Heiko Runz Shih-Jen Hwang Chunyu Liu Adam S. Butterworth Karsten Suhre Daniel Levy Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease
description	Genetic variation can influence levels of disease-related plasma proteins and, thus, contribute to the pathogenesis of complex diseases. Here, the authors perform genome-wide QTL analysis for 71 plasma proteins to identify causal proteins for coronary heart disease and provide a molecular QTL browser.
format	article
author	Chen Yao George Chen Ci Song Joshua Keefe Michael Mendelson Tianxiao Huan Benjamin B. Sun Annika Laser Joseph C. Maranville Hongsheng Wu Jennifer E. Ho Paul Courchesne Asya Lyass Martin G. Larson Christian Gieger Johannes Graumann Andrew D. Johnson John Danesh Heiko Runz Shih-Jen Hwang Chunyu Liu Adam S. Butterworth Karsten Suhre Daniel Levy
author_facet	Chen Yao George Chen Ci Song Joshua Keefe Michael Mendelson Tianxiao Huan Benjamin B. Sun Annika Laser Joseph C. Maranville Hongsheng Wu Jennifer E. Ho Paul Courchesne Asya Lyass Martin G. Larson Christian Gieger Johannes Graumann Andrew D. Johnson John Danesh Heiko Runz Shih-Jen Hwang Chunyu Liu Adam S. Butterworth Karsten Suhre Daniel Levy
author_sort	Chen Yao
title	Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease
title_short	Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease
title_full	Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease
title_fullStr	Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease
title_full_unstemmed	Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease
title_sort	genome‐wide mapping of plasma protein qtls identifies putatively causal genes and pathways for cardiovascular disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/cae1352d0a9c4818b111c7a3955ca2ac
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Genome‐wide mapping of plasma protein QTLs identifies putatively causal genes and pathways for cardiovascular disease

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