Genome-wide high-resolution aCGH analysis of gestational choriocarcinomas.

Eleven samples of DNA from choriocarcinomas were studied by high resolution CGH-array 244 K. They were studied after histopathological confirmation of the diagnosis, of the androgenic etiology and after a microsatellite marker analysis confirming the absence of contamination of tumor DNA from matern...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Henriette Poaty, Philippe Coullin, Jean Félix Peko, Philippe Dessen, Ange Lucien Diatta, Alexander Valent, Eric Leguern, Sophie Prévot, Charles Gombé-Mbalawa, Jean-Jacques Candelier, Jean-Yves Picard, Alain Bernheim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cae2dfb2a086447a9ef2e5339e231621
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cae2dfb2a086447a9ef2e5339e231621
record_format	dspace
spelling	oai:doaj.org-article:cae2dfb2a086447a9ef2e5339e2316212021-11-18T07:30:43ZGenome-wide high-resolution aCGH analysis of gestational choriocarcinomas.1932-620310.1371/journal.pone.0029426https://doaj.org/article/cae2dfb2a086447a9ef2e5339e2316212012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22253721/?tool=EBIhttps://doaj.org/toc/1932-6203Eleven samples of DNA from choriocarcinomas were studied by high resolution CGH-array 244 K. They were studied after histopathological confirmation of the diagnosis, of the androgenic etiology and after a microsatellite marker analysis confirming the absence of contamination of tumor DNA from maternal DNA. Three cell lines, BeWo, JAR, JEG were also studied by this high resolution pangenomic technique. According to aCGH analysis, the de novo choriocarcinomas exhibited simple chromosomal rearrangements or normal profiles. The cell lines showed various and complex chromosomal aberrations. 23 Minimal Critical Regions were defined that allowed us to list the genes that were potentially implicated. Among them, unusually high numbers of microRNA clusters and imprinted genes were observed.Henriette PoatyPhilippe CoullinJean Félix PekoPhilippe DessenAnge Lucien DiattaAlexander ValentEric LeguernSophie PrévotCharles Gombé-MbalawaJean-Jacques CandelierJean-Yves PicardAlain BernheimPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 1, p e29426 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Henriette Poaty Philippe Coullin Jean Félix Peko Philippe Dessen Ange Lucien Diatta Alexander Valent Eric Leguern Sophie Prévot Charles Gombé-Mbalawa Jean-Jacques Candelier Jean-Yves Picard Alain Bernheim Genome-wide high-resolution aCGH analysis of gestational choriocarcinomas.
description	Eleven samples of DNA from choriocarcinomas were studied by high resolution CGH-array 244 K. They were studied after histopathological confirmation of the diagnosis, of the androgenic etiology and after a microsatellite marker analysis confirming the absence of contamination of tumor DNA from maternal DNA. Three cell lines, BeWo, JAR, JEG were also studied by this high resolution pangenomic technique. According to aCGH analysis, the de novo choriocarcinomas exhibited simple chromosomal rearrangements or normal profiles. The cell lines showed various and complex chromosomal aberrations. 23 Minimal Critical Regions were defined that allowed us to list the genes that were potentially implicated. Among them, unusually high numbers of microRNA clusters and imprinted genes were observed.
format	article
author	Henriette Poaty Philippe Coullin Jean Félix Peko Philippe Dessen Ange Lucien Diatta Alexander Valent Eric Leguern Sophie Prévot Charles Gombé-Mbalawa Jean-Jacques Candelier Jean-Yves Picard Alain Bernheim
author_facet	Henriette Poaty Philippe Coullin Jean Félix Peko Philippe Dessen Ange Lucien Diatta Alexander Valent Eric Leguern Sophie Prévot Charles Gombé-Mbalawa Jean-Jacques Candelier Jean-Yves Picard Alain Bernheim
author_sort	Henriette Poaty
title	Genome-wide high-resolution aCGH analysis of gestational choriocarcinomas.
title_short	Genome-wide high-resolution aCGH analysis of gestational choriocarcinomas.
title_full	Genome-wide high-resolution aCGH analysis of gestational choriocarcinomas.
title_fullStr	Genome-wide high-resolution aCGH analysis of gestational choriocarcinomas.
title_full_unstemmed	Genome-wide high-resolution aCGH analysis of gestational choriocarcinomas.
title_sort	genome-wide high-resolution acgh analysis of gestational choriocarcinomas.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/cae2dfb2a086447a9ef2e5339e231621
work_keys_str_mv	AT henriettepoaty genomewidehighresolutionacghanalysisofgestationalchoriocarcinomas AT philippecoullin genomewidehighresolutionacghanalysisofgestationalchoriocarcinomas AT jeanfelixpeko genomewidehighresolutionacghanalysisofgestationalchoriocarcinomas AT philippedessen genomewidehighresolutionacghanalysisofgestationalchoriocarcinomas AT angeluciendiatta genomewidehighresolutionacghanalysisofgestationalchoriocarcinomas AT alexandervalent genomewidehighresolutionacghanalysisofgestationalchoriocarcinomas AT ericleguern genomewidehighresolutionacghanalysisofgestationalchoriocarcinomas AT sophieprevot genomewidehighresolutionacghanalysisofgestationalchoriocarcinomas AT charlesgombembalawa genomewidehighresolutionacghanalysisofgestationalchoriocarcinomas AT jeanjacquescandelier genomewidehighresolutionacghanalysisofgestationalchoriocarcinomas AT jeanyvespicard genomewidehighresolutionacghanalysisofgestationalchoriocarcinomas AT alainbernheim genomewidehighresolutionacghanalysisofgestationalchoriocarcinomas
_version_	1718423376004907008

Genome-wide high-resolution aCGH analysis of gestational choriocarcinomas.

Ejemplares similares