Secreted Protein Acidic and Rich in Cysteine as a Molecular Physiological and Pathological Biomarker

Secreted protein acidic and rich in cysteine (SPARC) is expressed in diverse tissues and plays roles in various biological functions and processes. Increased serum levels of SPARC or its gene overexpression have been reported following numerous physiological and pathological changes including injuri...

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Autores principales:	Abdelaziz Ghanemi, Mayumi Yoshioka, Jonny St-Amand
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	secreted protein acidic and rich in cysteine expression physiology pathology biomarker Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/cae2f316bbbd4fde96bd5c2222e08e1d
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spelling	oai:doaj.org-article:cae2f316bbbd4fde96bd5c2222e08e1d2021-11-25T16:53:51ZSecreted Protein Acidic and Rich in Cysteine as a Molecular Physiological and Pathological Biomarker10.3390/biom111116892218-273Xhttps://doaj.org/article/cae2f316bbbd4fde96bd5c2222e08e1d2021-11-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1689https://doaj.org/toc/2218-273XSecreted protein acidic and rich in cysteine (SPARC) is expressed in diverse tissues and plays roles in various biological functions and processes. Increased serum levels of SPARC or its gene overexpression have been reported following numerous physiological and pathological changes including injuries, exercise, regeneration, obesity, cancer, and inflammation. Such expression pattern interrelation between these biological changes and the SPARC expression/secretion points to it as a biomarker. This property could lead to a variety of potential applications ranging from mechanistic studies and animal model validation to the clinical and therapeutic evaluation of both disease prognosis and pharmacological agents.Abdelaziz GhanemiMayumi YoshiokaJonny St-AmandMDPI AGarticlesecreted protein acidic and rich in cysteineexpressionphysiologypathologybiomarkerMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1689, p 1689 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	secreted protein acidic and rich in cysteine expression physiology pathology biomarker Microbiology QR1-502
spellingShingle	secreted protein acidic and rich in cysteine expression physiology pathology biomarker Microbiology QR1-502 Abdelaziz Ghanemi Mayumi Yoshioka Jonny St-Amand Secreted Protein Acidic and Rich in Cysteine as a Molecular Physiological and Pathological Biomarker
description	Secreted protein acidic and rich in cysteine (SPARC) is expressed in diverse tissues and plays roles in various biological functions and processes. Increased serum levels of SPARC or its gene overexpression have been reported following numerous physiological and pathological changes including injuries, exercise, regeneration, obesity, cancer, and inflammation. Such expression pattern interrelation between these biological changes and the SPARC expression/secretion points to it as a biomarker. This property could lead to a variety of potential applications ranging from mechanistic studies and animal model validation to the clinical and therapeutic evaluation of both disease prognosis and pharmacological agents.
format	article
author	Abdelaziz Ghanemi Mayumi Yoshioka Jonny St-Amand
author_facet	Abdelaziz Ghanemi Mayumi Yoshioka Jonny St-Amand
author_sort	Abdelaziz Ghanemi
title	Secreted Protein Acidic and Rich in Cysteine as a Molecular Physiological and Pathological Biomarker
title_short	Secreted Protein Acidic and Rich in Cysteine as a Molecular Physiological and Pathological Biomarker
title_full	Secreted Protein Acidic and Rich in Cysteine as a Molecular Physiological and Pathological Biomarker
title_fullStr	Secreted Protein Acidic and Rich in Cysteine as a Molecular Physiological and Pathological Biomarker
title_full_unstemmed	Secreted Protein Acidic and Rich in Cysteine as a Molecular Physiological and Pathological Biomarker
title_sort	secreted protein acidic and rich in cysteine as a molecular physiological and pathological biomarker
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/cae2f316bbbd4fde96bd5c2222e08e1d
work_keys_str_mv	AT abdelazizghanemi secretedproteinacidicandrichincysteineasamolecularphysiologicalandpathologicalbiomarker AT mayumiyoshioka secretedproteinacidicandrichincysteineasamolecularphysiologicalandpathologicalbiomarker AT jonnystamand secretedproteinacidicandrichincysteineasamolecularphysiologicalandpathologicalbiomarker
_version_	1718412863521947648

Secreted Protein Acidic and Rich in Cysteine as a Molecular Physiological and Pathological Biomarker

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