CURRENT APPROACHES TO UNIVERSAL VACCINE AGAINST INFLUENZA VIRUS

Influenza is a seasonal infectious disease widespread across the globe. In Russia the share of influenza and other acute respiratory viral infections account for up to 90% of all infectious diseases. Scientific and reasonable method of influenza prevention is vaccination. However, traditional curren...

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Autores principales:	I. B. Esmagambetov, S. V. Alekseeva, K. S. Sayadyan, M. M. Shmarov
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2016
Materias:	influenza virus universal vaccine haemagglutinin m2 (ion channel) nucleoprotein wide range immune response Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/cae30481594f424ea89cbd65c91b0c9b
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spelling	oai:doaj.org-article:cae30481594f424ea89cbd65c91b0c9b2021-11-22T07:09:47ZCURRENT APPROACHES TO UNIVERSAL VACCINE AGAINST INFLUENZA VIRUS2220-76192313-739810.15789/2220-7619-2016-2-117-132https://doaj.org/article/cae30481594f424ea89cbd65c91b0c9b2016-06-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/397https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Influenza is a seasonal infectious disease widespread across the globe. In Russia the share of influenza and other acute respiratory viral infections account for up to 90% of all infectious diseases. Scientific and reasonable method of influenza prevention is vaccination. However, traditional current influenza vaccines can’t induce protection against various virus strains that differ substantially in terms of their antigenic structure, and thus require periodic updates to its immunogenic components. In addition, there is the risk of a pandemic caused by an entirely new antigen in relation to variants of influenza virus A. Attempts to improve on traditional approaches to vaccination have focused primarily on improving production technologies and to increase immunogenicity of vaccines. Therefore, the urgent task is the creation of vaccines able to induce immune response a broad spectrum against different influenza virus strains and human strains of avian influenza, also can cause disease in humans. Protective effect of universal vaccine should be the induction of integrated immune response, based on the formulation of cross-reactive antibodies and T cells. The development of such universal vaccine could remove the need for periodical strain composition update of existing vaccines and, accor dingly, will be able to give the vaccine manufacturer itself, production planning regardless of epidemic seasons. Currently, the most widely studied antigens as key components of flu vaccines are proteins M2 and NP as well as the hemagglutinin of influenza virus. This review summarizes and lists some data of domestic and foreign research on a universal influenza virus vaccine.I. B. EsmagambetovS. V. AlekseevaK. S. SayadyanM. M. ShmarovSankt-Peterburg : NIIÈM imeni Pasteraarticleinfluenza virusuniversal vaccinehaemagglutininm2 (ion channel)nucleoproteinwide range immune responseInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 6, Iss 2, Pp 117-132 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	influenza virus universal vaccine haemagglutinin m2 (ion channel) nucleoprotein wide range immune response Infectious and parasitic diseases RC109-216
spellingShingle	influenza virus universal vaccine haemagglutinin m2 (ion channel) nucleoprotein wide range immune response Infectious and parasitic diseases RC109-216 I. B. Esmagambetov S. V. Alekseeva K. S. Sayadyan M. M. Shmarov CURRENT APPROACHES TO UNIVERSAL VACCINE AGAINST INFLUENZA VIRUS
description	Influenza is a seasonal infectious disease widespread across the globe. In Russia the share of influenza and other acute respiratory viral infections account for up to 90% of all infectious diseases. Scientific and reasonable method of influenza prevention is vaccination. However, traditional current influenza vaccines can’t induce protection against various virus strains that differ substantially in terms of their antigenic structure, and thus require periodic updates to its immunogenic components. In addition, there is the risk of a pandemic caused by an entirely new antigen in relation to variants of influenza virus A. Attempts to improve on traditional approaches to vaccination have focused primarily on improving production technologies and to increase immunogenicity of vaccines. Therefore, the urgent task is the creation of vaccines able to induce immune response a broad spectrum against different influenza virus strains and human strains of avian influenza, also can cause disease in humans. Protective effect of universal vaccine should be the induction of integrated immune response, based on the formulation of cross-reactive antibodies and T cells. The development of such universal vaccine could remove the need for periodical strain composition update of existing vaccines and, accor dingly, will be able to give the vaccine manufacturer itself, production planning regardless of epidemic seasons. Currently, the most widely studied antigens as key components of flu vaccines are proteins M2 and NP as well as the hemagglutinin of influenza virus. This review summarizes and lists some data of domestic and foreign research on a universal influenza virus vaccine.
format	article
author	I. B. Esmagambetov S. V. Alekseeva K. S. Sayadyan M. M. Shmarov
author_facet	I. B. Esmagambetov S. V. Alekseeva K. S. Sayadyan M. M. Shmarov
author_sort	I. B. Esmagambetov
title	CURRENT APPROACHES TO UNIVERSAL VACCINE AGAINST INFLUENZA VIRUS
title_short	CURRENT APPROACHES TO UNIVERSAL VACCINE AGAINST INFLUENZA VIRUS
title_full	CURRENT APPROACHES TO UNIVERSAL VACCINE AGAINST INFLUENZA VIRUS
title_fullStr	CURRENT APPROACHES TO UNIVERSAL VACCINE AGAINST INFLUENZA VIRUS
title_full_unstemmed	CURRENT APPROACHES TO UNIVERSAL VACCINE AGAINST INFLUENZA VIRUS
title_sort	current approaches to universal vaccine against influenza virus
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2016
url	https://doaj.org/article/cae30481594f424ea89cbd65c91b0c9b
work_keys_str_mv	AT ibesmagambetov currentapproachestouniversalvaccineagainstinfluenzavirus AT svalekseeva currentapproachestouniversalvaccineagainstinfluenzavirus AT kssayadyan currentapproachestouniversalvaccineagainstinfluenzavirus AT mmshmarov currentapproachestouniversalvaccineagainstinfluenzavirus
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CURRENT APPROACHES TO UNIVERSAL VACCINE AGAINST INFLUENZA VIRUS

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