Malnutrition Risk, Physical Function Decline and Disability in Middle-Aged and Older Adults Followed Up in the Singapore Longitudinal Ageing Study

Shan Hai,1 Qi Gao,2 Xinyi Gwee,2 Denise Qian Ling Chua,2 Keng Bee Yap,3 Tze Pin Ng2 1Gerontology and Geriatrics Centre, West China Hospital of Sichuan University, Chengdu, People’s Republic of China; 2Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singa...

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Autores principales:	Hai S, Gao Q, Gwee X, Chua DQL, Yap KB, Ng TP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	malnutrition functionality ageing prospective cohort study Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/cae31b7373cc490faa90ad1c84448447
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spelling	oai:doaj.org-article:cae31b7373cc490faa90ad1c844484472021-12-02T16:45:43ZMalnutrition Risk, Physical Function Decline and Disability in Middle-Aged and Older Adults Followed Up in the Singapore Longitudinal Ageing Study1178-1998https://doaj.org/article/cae31b7373cc490faa90ad1c844484472021-08-01T00:00:00Zhttps://www.dovepress.com/malnutrition-risk-physical-function-decline-and-disability-in-middle-a-peer-reviewed-fulltext-article-CIAhttps://doaj.org/toc/1178-1998Shan Hai,1 Qi Gao,2 Xinyi Gwee,2 Denise Qian Ling Chua,2 Keng Bee Yap,3 Tze Pin Ng2 1Gerontology and Geriatrics Centre, West China Hospital of Sichuan University, Chengdu, People’s Republic of China; 2Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 3Department of Medicine, Ng Teng Fong General Hospital, SingaporeCorrespondence: Tze Pin NgDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Level 9, NUHS Tower Block, 1E Kent Ridge Road, 119228, SingaporeTel +65 6772 4518; +65 6772 3478Fax +65 6777 2191Email pcmngtp@nus.edu.sgPurpose: Malnutrition and population ageing are doubly global healthcare challenges. It is widely recognized that disability is a major contributor to malnutrition among older people, but the importance of reducing malnutrition risk (MR) for disability prevention is given little attention. We investigated the association between MR and risk of incident disability and functional decline among community-dwelling older persons.Materials and Methods: Prospective cohort study of community-dwelling older adults aged 55 and above (Singapore Longitudinal Ageing Study) with 3– 5 years follow-up. MR was measured at baseline using an appropriate and validated index (ENIGMA); physical and functional measures at baseline and follow-up included instrumental and basic activity of daily living (ADL), knee extension (KES), gait velocity (GV), timed up-and-go (TUG).Results: Compared to low MR, mild-moderate MR (OR = 1.43, 95% CI = 1.02– 2.01) and severe MR (OR=1.74, 95% CI=1.10– 2.74) were associated with higher risks of incident disability. Severe MR was associated with functional decline (OR = 1.69, 95% CI = 1.11– 2.57). Estimates were adjusted for demographic, social, lifestyle behaviour and health variables. In particular, eating difficulty was associated with incident disability and functional decline, and low lymphocyte with functional decline. Severe MR and low albumin were associated with 37% worse GV and 126% worse TUG declines; consuming few vegetables or fruits with 34% worse KES decline; polypharmacy with 56% worse TUG decline.Conclusion: Malnutrition risk increased the risk of incident disability and functional decline in non-disabled persons, it worsened physical performance declines. Further studies should investigate the effectiveness of nutritional interventions in reducing the risk of disability among older people.Keywords: malnutrition, functionality, ageing, prospective cohort studyHai SGao QGwee XChua DQLYap KBNg TPDove Medical Pressarticlemalnutritionfunctionalityageingprospective cohort studyGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 16, Pp 1527-1539 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	malnutrition functionality ageing prospective cohort study Geriatrics RC952-954.6
spellingShingle	malnutrition functionality ageing prospective cohort study Geriatrics RC952-954.6 Hai S Gao Q Gwee X Chua DQL Yap KB Ng TP Malnutrition Risk, Physical Function Decline and Disability in Middle-Aged and Older Adults Followed Up in the Singapore Longitudinal Ageing Study
description	Shan Hai,1 Qi Gao,2 Xinyi Gwee,2 Denise Qian Ling Chua,2 Keng Bee Yap,3 Tze Pin Ng2 1Gerontology and Geriatrics Centre, West China Hospital of Sichuan University, Chengdu, People’s Republic of China; 2Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 3Department of Medicine, Ng Teng Fong General Hospital, SingaporeCorrespondence: Tze Pin NgDepartment of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Level 9, NUHS Tower Block, 1E Kent Ridge Road, 119228, SingaporeTel +65 6772 4518; +65 6772 3478Fax +65 6777 2191Email pcmngtp@nus.edu.sgPurpose: Malnutrition and population ageing are doubly global healthcare challenges. It is widely recognized that disability is a major contributor to malnutrition among older people, but the importance of reducing malnutrition risk (MR) for disability prevention is given little attention. We investigated the association between MR and risk of incident disability and functional decline among community-dwelling older persons.Materials and Methods: Prospective cohort study of community-dwelling older adults aged 55 and above (Singapore Longitudinal Ageing Study) with 3– 5 years follow-up. MR was measured at baseline using an appropriate and validated index (ENIGMA); physical and functional measures at baseline and follow-up included instrumental and basic activity of daily living (ADL), knee extension (KES), gait velocity (GV), timed up-and-go (TUG).Results: Compared to low MR, mild-moderate MR (OR = 1.43, 95% CI = 1.02– 2.01) and severe MR (OR=1.74, 95% CI=1.10– 2.74) were associated with higher risks of incident disability. Severe MR was associated with functional decline (OR = 1.69, 95% CI = 1.11– 2.57). Estimates were adjusted for demographic, social, lifestyle behaviour and health variables. In particular, eating difficulty was associated with incident disability and functional decline, and low lymphocyte with functional decline. Severe MR and low albumin were associated with 37% worse GV and 126% worse TUG declines; consuming few vegetables or fruits with 34% worse KES decline; polypharmacy with 56% worse TUG decline.Conclusion: Malnutrition risk increased the risk of incident disability and functional decline in non-disabled persons, it worsened physical performance declines. Further studies should investigate the effectiveness of nutritional interventions in reducing the risk of disability among older people.Keywords: malnutrition, functionality, ageing, prospective cohort study
format	article
author	Hai S Gao Q Gwee X Chua DQL Yap KB Ng TP
author_facet	Hai S Gao Q Gwee X Chua DQL Yap KB Ng TP
author_sort	Hai S
title	Malnutrition Risk, Physical Function Decline and Disability in Middle-Aged and Older Adults Followed Up in the Singapore Longitudinal Ageing Study
title_short	Malnutrition Risk, Physical Function Decline and Disability in Middle-Aged and Older Adults Followed Up in the Singapore Longitudinal Ageing Study
title_full	Malnutrition Risk, Physical Function Decline and Disability in Middle-Aged and Older Adults Followed Up in the Singapore Longitudinal Ageing Study
title_fullStr	Malnutrition Risk, Physical Function Decline and Disability in Middle-Aged and Older Adults Followed Up in the Singapore Longitudinal Ageing Study
title_full_unstemmed	Malnutrition Risk, Physical Function Decline and Disability in Middle-Aged and Older Adults Followed Up in the Singapore Longitudinal Ageing Study
title_sort	malnutrition risk, physical function decline and disability in middle-aged and older adults followed up in the singapore longitudinal ageing study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/cae31b7373cc490faa90ad1c84448447
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Malnutrition Risk, Physical Function Decline and Disability in Middle-Aged and Older Adults Followed Up in the Singapore Longitudinal Ageing Study

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