Optimisation of a Novel Spiral-Inducing Bypass Graft Using Computational Fluid Dynamics

Abstract Graft failure is currently a major concern for medical practitioners in treating Peripheral Vascular Disease (PVD) and Coronary Artery Disease (CAD). It is now widely accepted that unfavourable haemodynamic conditions play an essential role in the formation and development of intimal hyperp...

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Autores principales:	Andres Ruiz-Soler, Foad Kabinejadian, Mark A. Slevin, Paulo J. Bartolo, Amir Keshmiri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/cae776921cf54c72878a1e60b74b5702
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spelling	oai:doaj.org-article:cae776921cf54c72878a1e60b74b57022021-12-02T16:06:28ZOptimisation of a Novel Spiral-Inducing Bypass Graft Using Computational Fluid Dynamics10.1038/s41598-017-01930-x2045-2322https://doaj.org/article/cae776921cf54c72878a1e60b74b57022017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-01930-xhttps://doaj.org/toc/2045-2322Abstract Graft failure is currently a major concern for medical practitioners in treating Peripheral Vascular Disease (PVD) and Coronary Artery Disease (CAD). It is now widely accepted that unfavourable haemodynamic conditions play an essential role in the formation and development of intimal hyperplasia, which is the main cause of graft failure. This paper uses Computational Fluid Dynamics (CFD) to conduct a parametric study to enhance the design and performance of a novel prosthetic graft, which utilises internal ridge(s) to induce spiral flow. This design is primarily based on the identification of the blood flow as spiral in the whole arterial system and is believed to improve the graft longevity and patency rates at distal graft anastomoses. Four different design parameters were assessed in this work and the trailing edge orientation of the ridge was identified as the most important parameter to induce physiological swirling flow, while the height of the ridge also significantly contributed to the enhanced performance of this type of graft. Building on these conclusions, an enhanced configuration of spiral graft is proposed and compared against conventional and spiral grafts to reaffirm its potential benefits.Andres Ruiz-SolerFoad KabinejadianMark A. SlevinPaulo J. BartoloAmir KeshmiriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andres Ruiz-Soler Foad Kabinejadian Mark A. Slevin Paulo J. Bartolo Amir Keshmiri Optimisation of a Novel Spiral-Inducing Bypass Graft Using Computational Fluid Dynamics
description	Abstract Graft failure is currently a major concern for medical practitioners in treating Peripheral Vascular Disease (PVD) and Coronary Artery Disease (CAD). It is now widely accepted that unfavourable haemodynamic conditions play an essential role in the formation and development of intimal hyperplasia, which is the main cause of graft failure. This paper uses Computational Fluid Dynamics (CFD) to conduct a parametric study to enhance the design and performance of a novel prosthetic graft, which utilises internal ridge(s) to induce spiral flow. This design is primarily based on the identification of the blood flow as spiral in the whole arterial system and is believed to improve the graft longevity and patency rates at distal graft anastomoses. Four different design parameters were assessed in this work and the trailing edge orientation of the ridge was identified as the most important parameter to induce physiological swirling flow, while the height of the ridge also significantly contributed to the enhanced performance of this type of graft. Building on these conclusions, an enhanced configuration of spiral graft is proposed and compared against conventional and spiral grafts to reaffirm its potential benefits.
format	article
author	Andres Ruiz-Soler Foad Kabinejadian Mark A. Slevin Paulo J. Bartolo Amir Keshmiri
author_facet	Andres Ruiz-Soler Foad Kabinejadian Mark A. Slevin Paulo J. Bartolo Amir Keshmiri
author_sort	Andres Ruiz-Soler
title	Optimisation of a Novel Spiral-Inducing Bypass Graft Using Computational Fluid Dynamics
title_short	Optimisation of a Novel Spiral-Inducing Bypass Graft Using Computational Fluid Dynamics
title_full	Optimisation of a Novel Spiral-Inducing Bypass Graft Using Computational Fluid Dynamics
title_fullStr	Optimisation of a Novel Spiral-Inducing Bypass Graft Using Computational Fluid Dynamics
title_full_unstemmed	Optimisation of a Novel Spiral-Inducing Bypass Graft Using Computational Fluid Dynamics
title_sort	optimisation of a novel spiral-inducing bypass graft using computational fluid dynamics
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cae776921cf54c72878a1e60b74b5702
work_keys_str_mv	AT andresruizsoler optimisationofanovelspiralinducingbypassgraftusingcomputationalfluiddynamics AT foadkabinejadian optimisationofanovelspiralinducingbypassgraftusingcomputationalfluiddynamics AT markaslevin optimisationofanovelspiralinducingbypassgraftusingcomputationalfluiddynamics AT paulojbartolo optimisationofanovelspiralinducingbypassgraftusingcomputationalfluiddynamics AT amirkeshmiri optimisationofanovelspiralinducingbypassgraftusingcomputationalfluiddynamics
_version_	1718384989851090944

Optimisation of a Novel Spiral-Inducing Bypass Graft Using Computational Fluid Dynamics

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