hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy

Acute myeloid leukemia cells are often resistant to radiotherapy and chemotherapy. Here, the authors suggest that hCINAP contributes to the resistance of acute myeloid leukemia cells by regulating SUMOylation of Nucleophosmin during the DNA-damage response.

Guardado en:

Detalles Bibliográficos
Autores principales:	Ruidan Xu, Shuyu Yu, Dan Zhu, Xinping Huang, Yuqi Xu, Yimin Lao, Yonglu Tian, Jinfang Zhang, Zefang Tang, Zemin Zhang, Jing Yi, Hong-Hu Zhu, Xiaofeng Zheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/caea99c77e2349bc964a9ae562bf4dbe
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:caea99c77e2349bc964a9ae562bf4dbe
record_format	dspace
spelling	oai:doaj.org-article:caea99c77e2349bc964a9ae562bf4dbe2021-12-02T15:35:31ZhCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy10.1038/s41467-019-11795-52041-1723https://doaj.org/article/caea99c77e2349bc964a9ae562bf4dbe2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11795-5https://doaj.org/toc/2041-1723Acute myeloid leukemia cells are often resistant to radiotherapy and chemotherapy. Here, the authors suggest that hCINAP contributes to the resistance of acute myeloid leukemia cells by regulating SUMOylation of Nucleophosmin during the DNA-damage response.Ruidan XuShuyu YuDan ZhuXinping HuangYuqi XuYimin LaoYonglu TianJinfang ZhangZefang TangZemin ZhangJing YiHong-Hu ZhuXiaofeng ZhengNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ruidan Xu Shuyu Yu Dan Zhu Xinping Huang Yuqi Xu Yimin Lao Yonglu Tian Jinfang Zhang Zefang Tang Zemin Zhang Jing Yi Hong-Hu Zhu Xiaofeng Zheng hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy
description	Acute myeloid leukemia cells are often resistant to radiotherapy and chemotherapy. Here, the authors suggest that hCINAP contributes to the resistance of acute myeloid leukemia cells by regulating SUMOylation of Nucleophosmin during the DNA-damage response.
format	article
author	Ruidan Xu Shuyu Yu Dan Zhu Xinping Huang Yuqi Xu Yimin Lao Yonglu Tian Jinfang Zhang Zefang Tang Zemin Zhang Jing Yi Hong-Hu Zhu Xiaofeng Zheng
author_facet	Ruidan Xu Shuyu Yu Dan Zhu Xinping Huang Yuqi Xu Yimin Lao Yonglu Tian Jinfang Zhang Zefang Tang Zemin Zhang Jing Yi Hong-Hu Zhu Xiaofeng Zheng
author_sort	Ruidan Xu
title	hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy
title_short	hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy
title_full	hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy
title_fullStr	hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy
title_full_unstemmed	hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy
title_sort	hcinap regulates the dna-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/caea99c77e2349bc964a9ae562bf4dbe
work_keys_str_mv	AT ruidanxu hcinapregulatesthednadamageresponseandmediatestheresistanceofacutemyelocyticleukemiacellstotherapy AT shuyuyu hcinapregulatesthednadamageresponseandmediatestheresistanceofacutemyelocyticleukemiacellstotherapy AT danzhu hcinapregulatesthednadamageresponseandmediatestheresistanceofacutemyelocyticleukemiacellstotherapy AT xinpinghuang hcinapregulatesthednadamageresponseandmediatestheresistanceofacutemyelocyticleukemiacellstotherapy AT yuqixu hcinapregulatesthednadamageresponseandmediatestheresistanceofacutemyelocyticleukemiacellstotherapy AT yiminlao hcinapregulatesthednadamageresponseandmediatestheresistanceofacutemyelocyticleukemiacellstotherapy AT yonglutian hcinapregulatesthednadamageresponseandmediatestheresistanceofacutemyelocyticleukemiacellstotherapy AT jinfangzhang hcinapregulatesthednadamageresponseandmediatestheresistanceofacutemyelocyticleukemiacellstotherapy AT zefangtang hcinapregulatesthednadamageresponseandmediatestheresistanceofacutemyelocyticleukemiacellstotherapy AT zeminzhang hcinapregulatesthednadamageresponseandmediatestheresistanceofacutemyelocyticleukemiacellstotherapy AT jingyi hcinapregulatesthednadamageresponseandmediatestheresistanceofacutemyelocyticleukemiacellstotherapy AT honghuzhu hcinapregulatesthednadamageresponseandmediatestheresistanceofacutemyelocyticleukemiacellstotherapy AT xiaofengzheng hcinapregulatesthednadamageresponseandmediatestheresistanceofacutemyelocyticleukemiacellstotherapy
_version_	1718386560951386112

hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy

Ejemplares similares