hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy

hCINAP regulates the DNA-damage response and mediates the resistance of acute myelocytic leukemia cells to therapy

Acute myeloid leukemia cells are often resistant to radiotherapy and chemotherapy. Here, the authors suggest that hCINAP contributes to the resistance of acute myeloid leukemia cells by regulating SUMOylation of Nucleophosmin during the DNA-damage response.

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Detalles Bibliográficos
Autores principales: Ruidan Xu, Shuyu Yu, Dan Zhu, Xinping Huang, Yuqi Xu, Yimin Lao, Yonglu Tian, Jinfang Zhang, Zefang Tang, Zemin Zhang, Jing Yi, Hong-Hu Zhu, Xiaofeng Zheng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
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Acceso en línea:https://doaj.org/article/caea99c77e2349bc964a9ae562bf4dbe
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