Effect of Sublingual Misoprostol Prior to Insertion of Intrauterine Device in Women with no Previous Vaginal Delivery

Background: The intrauterine device [IUD] is a safe and effective method of contraception, fear of pain during insertion discourages some providers to recommend IUDs to women with no previous vaginal delivery. Aim of the work:The aim of the study is to evaluate sublingual misoprostol 200µg on the...

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Autores principales:	Zeinab Elgharbawy, Abd Elraouf Oun, Waleed Ayad
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2020
Materias:	misoprostol intrauterine device Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/caeb0faa68804fa69ee0b379632d4ce4
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spelling	oai:doaj.org-article:caeb0faa68804fa69ee0b379632d4ce42021-12-02T10:38:27ZEffect of Sublingual Misoprostol Prior to Insertion of Intrauterine Device in Women with no Previous Vaginal Delivery2636-41742682-378010.21608/ijma.2020.22013.1075https://doaj.org/article/caeb0faa68804fa69ee0b379632d4ce42020-07-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_85217_a43d554a8352744febd5205f0d03a6c4.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: The intrauterine device [IUD] is a safe and effective method of contraception, fear of pain during insertion discourages some providers to recommend IUDs to women with no previous vaginal delivery. Aim of the work:The aim of the study is to evaluate sublingual misoprostol 200µg on the cervix one hour before IUD insertion; to facilitate IUD insertion in women with tight cervix or in whom did not deliver vaginally. Patients and Methods:The study was a double blinded randomized controlled trial, compared sublingual 200µg misoprostol with placebo. The study included 260 cases attended the Gynecology Clinic [Al-Azhar University Hospital] from December 2018 to November 2019. All females signed an informed written consent, and then have been randomly divided into 2 groups using a closed envelope technique. Every female had been asked to take the drug sublingually then return after one hour to insert her IUD. Group A included 130 females who used sublingual misoprostol 200µg [Misotac] and group B included 130 females who took a placebo one hour before IUD insertion [Control group]. Results: IUD and uterine sound insertion was unsuccessful in 8.5% of group A versus 13.8% in group B while it was successful in 91.5% of group A versus 86.2% in Group B. Among the successful cases, 88[73.9] were easy in group A versus 77[68.8] in group B. On the other hand, 31[26.1%] and 35[31.2%] were difficult in group A and B respectively. With no significant difference between both groups either in IUD or uterine sound insertion successful or easiness rate [p=0.17 & 0.38 respectively] Conclusion: Using of misoprostol to facilitate IUD insertion in women with tight cervix, has no role in pain reduction or increase the ease of IUD insertion, although results with misoprostol are superior to placebo, but the different did not reach statistical significanceZeinab ElgharbawyAbd Elraouf OunWaleed AyadAl-Azhar University, Faculty of Medicine (Damietta)articlemisoprostolintrauterinedeviceMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 2, Iss 3, Pp 668-673 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	misoprostol intrauterine device Medicine (General) R5-920
spellingShingle	misoprostol intrauterine device Medicine (General) R5-920 Zeinab Elgharbawy Abd Elraouf Oun Waleed Ayad Effect of Sublingual Misoprostol Prior to Insertion of Intrauterine Device in Women with no Previous Vaginal Delivery
description	Background: The intrauterine device [IUD] is a safe and effective method of contraception, fear of pain during insertion discourages some providers to recommend IUDs to women with no previous vaginal delivery. Aim of the work:The aim of the study is to evaluate sublingual misoprostol 200µg on the cervix one hour before IUD insertion; to facilitate IUD insertion in women with tight cervix or in whom did not deliver vaginally. Patients and Methods:The study was a double blinded randomized controlled trial, compared sublingual 200µg misoprostol with placebo. The study included 260 cases attended the Gynecology Clinic [Al-Azhar University Hospital] from December 2018 to November 2019. All females signed an informed written consent, and then have been randomly divided into 2 groups using a closed envelope technique. Every female had been asked to take the drug sublingually then return after one hour to insert her IUD. Group A included 130 females who used sublingual misoprostol 200µg [Misotac] and group B included 130 females who took a placebo one hour before IUD insertion [Control group]. Results: IUD and uterine sound insertion was unsuccessful in 8.5% of group A versus 13.8% in group B while it was successful in 91.5% of group A versus 86.2% in Group B. Among the successful cases, 88[73.9] were easy in group A versus 77[68.8] in group B. On the other hand, 31[26.1%] and 35[31.2%] were difficult in group A and B respectively. With no significant difference between both groups either in IUD or uterine sound insertion successful or easiness rate [p=0.17 & 0.38 respectively] Conclusion: Using of misoprostol to facilitate IUD insertion in women with tight cervix, has no role in pain reduction or increase the ease of IUD insertion, although results with misoprostol are superior to placebo, but the different did not reach statistical significance
format	article
author	Zeinab Elgharbawy Abd Elraouf Oun Waleed Ayad
author_facet	Zeinab Elgharbawy Abd Elraouf Oun Waleed Ayad
author_sort	Zeinab Elgharbawy
title	Effect of Sublingual Misoprostol Prior to Insertion of Intrauterine Device in Women with no Previous Vaginal Delivery
title_short	Effect of Sublingual Misoprostol Prior to Insertion of Intrauterine Device in Women with no Previous Vaginal Delivery
title_full	Effect of Sublingual Misoprostol Prior to Insertion of Intrauterine Device in Women with no Previous Vaginal Delivery
title_fullStr	Effect of Sublingual Misoprostol Prior to Insertion of Intrauterine Device in Women with no Previous Vaginal Delivery
title_full_unstemmed	Effect of Sublingual Misoprostol Prior to Insertion of Intrauterine Device in Women with no Previous Vaginal Delivery
title_sort	effect of sublingual misoprostol prior to insertion of intrauterine device in women with no previous vaginal delivery
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2020
url	https://doaj.org/article/caeb0faa68804fa69ee0b379632d4ce4
work_keys_str_mv	AT zeinabelgharbawy effectofsublingualmisoprostolpriortoinsertionofintrauterinedeviceinwomenwithnopreviousvaginaldelivery AT abdelraoufoun effectofsublingualmisoprostolpriortoinsertionofintrauterinedeviceinwomenwithnopreviousvaginaldelivery AT waleedayad effectofsublingualmisoprostolpriortoinsertionofintrauterinedeviceinwomenwithnopreviousvaginaldelivery
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Effect of Sublingual Misoprostol Prior to Insertion of Intrauterine Device in Women with no Previous Vaginal Delivery

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