Application of Clustering Method to Explore the Correlation Between Dominant Flora and the Autism Spectrum Disorder Clinical Phenotype in Chinese Children

Autism spectrum disorder (ASD) is characterized by deficits in social interactions and repetitive, stereotypic behaviors. Evidence shows that bidirectional communication of the gut-brain axis plays an important role. Here, we recruited 62 patients with ASD in southern China, and performed a cross-se...

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Autores principales:	Biyuan Chen, Na You, Bangquan Pan, Xueyi He, Xiaobing Zou
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	autism spectrum disorder gut microbiome repetitive behavior microbiome composition alpha diversity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/caeca6fa009d446f90eeff836b40c803
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id	oai:doaj.org-article:caeca6fa009d446f90eeff836b40c803
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spelling	oai:doaj.org-article:caeca6fa009d446f90eeff836b40c8032021-11-30T18:28:14ZApplication of Clustering Method to Explore the Correlation Between Dominant Flora and the Autism Spectrum Disorder Clinical Phenotype in Chinese Children1662-453X10.3389/fnins.2021.760779https://doaj.org/article/caeca6fa009d446f90eeff836b40c8032021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnins.2021.760779/fullhttps://doaj.org/toc/1662-453XAutism spectrum disorder (ASD) is characterized by deficits in social interactions and repetitive, stereotypic behaviors. Evidence shows that bidirectional communication of the gut-brain axis plays an important role. Here, we recruited 62 patients with ASD in southern China, and performed a cross-sectional study to test the relationship between repeated behavior, gut microbiome composition, and alpha diversity. We divided all participants into two groups based on the clustering results of their microbial compositions and found Veillonella and Ruminococcus as the seed genera in each group. Repetitive behavior differed between clusters, and cluster 2 had milder repetitive symptoms than Cluster 1. Alpha diversity between clusters was significantly different, indicating that cluster 1 had lower alpha diversity and more severe repetitive, stereotypic behaviors. Repetitive behavior had a negative correlation with alpha diversity. We demonstrated that the difference in intestinal microbiome composition and altered alpha diversity can be associated with repetitive, stereotypic behavior in autism. The role of Ruminococcus and Veillonella in ASD is not yet understood.Biyuan ChenNa YouBangquan PanXueyi HeXiaobing ZouFrontiers Media S.A.articleautism spectrum disordergut microbiomerepetitive behaviormicrobiome compositionalpha diversityNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autism spectrum disorder gut microbiome repetitive behavior microbiome composition alpha diversity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	autism spectrum disorder gut microbiome repetitive behavior microbiome composition alpha diversity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Biyuan Chen Na You Bangquan Pan Xueyi He Xiaobing Zou Application of Clustering Method to Explore the Correlation Between Dominant Flora and the Autism Spectrum Disorder Clinical Phenotype in Chinese Children
description	Autism spectrum disorder (ASD) is characterized by deficits in social interactions and repetitive, stereotypic behaviors. Evidence shows that bidirectional communication of the gut-brain axis plays an important role. Here, we recruited 62 patients with ASD in southern China, and performed a cross-sectional study to test the relationship between repeated behavior, gut microbiome composition, and alpha diversity. We divided all participants into two groups based on the clustering results of their microbial compositions and found Veillonella and Ruminococcus as the seed genera in each group. Repetitive behavior differed between clusters, and cluster 2 had milder repetitive symptoms than Cluster 1. Alpha diversity between clusters was significantly different, indicating that cluster 1 had lower alpha diversity and more severe repetitive, stereotypic behaviors. Repetitive behavior had a negative correlation with alpha diversity. We demonstrated that the difference in intestinal microbiome composition and altered alpha diversity can be associated with repetitive, stereotypic behavior in autism. The role of Ruminococcus and Veillonella in ASD is not yet understood.
format	article
author	Biyuan Chen Na You Bangquan Pan Xueyi He Xiaobing Zou
author_facet	Biyuan Chen Na You Bangquan Pan Xueyi He Xiaobing Zou
author_sort	Biyuan Chen
title	Application of Clustering Method to Explore the Correlation Between Dominant Flora and the Autism Spectrum Disorder Clinical Phenotype in Chinese Children
title_short	Application of Clustering Method to Explore the Correlation Between Dominant Flora and the Autism Spectrum Disorder Clinical Phenotype in Chinese Children
title_full	Application of Clustering Method to Explore the Correlation Between Dominant Flora and the Autism Spectrum Disorder Clinical Phenotype in Chinese Children
title_fullStr	Application of Clustering Method to Explore the Correlation Between Dominant Flora and the Autism Spectrum Disorder Clinical Phenotype in Chinese Children
title_full_unstemmed	Application of Clustering Method to Explore the Correlation Between Dominant Flora and the Autism Spectrum Disorder Clinical Phenotype in Chinese Children
title_sort	application of clustering method to explore the correlation between dominant flora and the autism spectrum disorder clinical phenotype in chinese children
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/caeca6fa009d446f90eeff836b40c803
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Application of Clustering Method to Explore the Correlation Between Dominant Flora and the Autism Spectrum Disorder Clinical Phenotype in Chinese Children

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