The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel

The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel

The capsaicin receptor TRPV1 has been structurally characterized, but the capsaicin activation dynamics remain elusive. Here authors use fluorescent unnatural amino acid incorporation, computational modeling and Φ-analysis to derive the capsaicin-bound open state model and reveal the capsaicin induc...

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Autores principales: Fan Yang, Xian Xiao, Bo Hyun Lee, Simon Vu, Wei Yang, Vladimir Yarov-Yarovoy, Jie Zheng
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/caedacb6329047018a4de94230ee9e09
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spelling oai:doaj.org-article:caedacb6329047018a4de94230ee9e092021-12-02T15:34:49ZThe conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel10.1038/s41467-018-05339-62041-1723https://doaj.org/article/caedacb6329047018a4de94230ee9e092018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05339-6https://doaj.org/toc/2041-1723The capsaicin receptor TRPV1 has been structurally characterized, but the capsaicin activation dynamics remain elusive. Here authors use fluorescent unnatural amino acid incorporation, computational modeling and Φ-analysis to derive the capsaicin-bound open state model and reveal the capsaicin induced conformational changes.Fan YangXian XiaoBo Hyun LeeSimon VuWei YangVladimir Yarov-YarovoyJie ZhengNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Fan Yang
Xian Xiao
Bo Hyun Lee
Simon Vu
Wei Yang
Vladimir Yarov-Yarovoy
Jie Zheng
The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel
description The capsaicin receptor TRPV1 has been structurally characterized, but the capsaicin activation dynamics remain elusive. Here authors use fluorescent unnatural amino acid incorporation, computational modeling and Φ-analysis to derive the capsaicin-bound open state model and reveal the capsaicin induced conformational changes.
format article
author Fan Yang
Xian Xiao
Bo Hyun Lee
Simon Vu
Wei Yang
Vladimir Yarov-Yarovoy
Jie Zheng
author_facet Fan Yang
Xian Xiao
Bo Hyun Lee
Simon Vu
Wei Yang
Vladimir Yarov-Yarovoy
Jie Zheng
author_sort Fan Yang
title The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel
title_short The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel
title_full The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel
title_fullStr The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel
title_full_unstemmed The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel
title_sort conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/caedacb6329047018a4de94230ee9e09
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