The variability of functional MRI brain signal increases in Alzheimer's disease at cardiorespiratory frequencies
Abstract Biomarkers sensitive to prodromal or early pathophysiological changes in Alzheimer’s disease (AD) symptoms could improve disease detection and enable timely interventions. Changes in brain hemodynamics may be associated with the main clinical AD symptoms. To test this possibility, we measur...
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2020
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oai:doaj.org-article:caee84f1ec8b4f068b3915608e8cac852021-12-02T12:33:05ZThe variability of functional MRI brain signal increases in Alzheimer's disease at cardiorespiratory frequencies10.1038/s41598-020-77984-12045-2322https://doaj.org/article/caee84f1ec8b4f068b3915608e8cac852020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77984-1https://doaj.org/toc/2045-2322Abstract Biomarkers sensitive to prodromal or early pathophysiological changes in Alzheimer’s disease (AD) symptoms could improve disease detection and enable timely interventions. Changes in brain hemodynamics may be associated with the main clinical AD symptoms. To test this possibility, we measured the variability of blood oxygen level-dependent (BOLD) signal in individuals from three independent datasets (totaling 80 AD patients and 90 controls). We detected a replicable increase in brain BOLD signal variability in the AD populations, which constituted a robust biomarker for clearly differentiating AD cases from controls. Fast BOLD scans showed that the elevated BOLD signal variability in AD arises mainly from cardiovascular brain pulsations. Manifesting in abnormal cerebral perfusion and cerebrospinal fluid convection, present observation presents a mechanism explaining earlier observations of impaired glymphatic clearance associated with AD in humans.Timo TuovinenJanne KananenZalan RajnaJohannes LieslehtoVesa KorhonenRiikka RyttyHeli MattilaNiko HuotariLauri RaitamaaHeta HelakariAhmed Abou ElseoudJohanna KrügerPierre LeVanOsmo TervonenJuergen HennigAnne M. RemesMaiken NedergaardVesa KiviniemiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) |
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Medicine R Science Q Timo Tuovinen Janne Kananen Zalan Rajna Johannes Lieslehto Vesa Korhonen Riikka Rytty Heli Mattila Niko Huotari Lauri Raitamaa Heta Helakari Ahmed Abou Elseoud Johanna Krüger Pierre LeVan Osmo Tervonen Juergen Hennig Anne M. Remes Maiken Nedergaard Vesa Kiviniemi The variability of functional MRI brain signal increases in Alzheimer's disease at cardiorespiratory frequencies |
| description |
Abstract Biomarkers sensitive to prodromal or early pathophysiological changes in Alzheimer’s disease (AD) symptoms could improve disease detection and enable timely interventions. Changes in brain hemodynamics may be associated with the main clinical AD symptoms. To test this possibility, we measured the variability of blood oxygen level-dependent (BOLD) signal in individuals from three independent datasets (totaling 80 AD patients and 90 controls). We detected a replicable increase in brain BOLD signal variability in the AD populations, which constituted a robust biomarker for clearly differentiating AD cases from controls. Fast BOLD scans showed that the elevated BOLD signal variability in AD arises mainly from cardiovascular brain pulsations. Manifesting in abnormal cerebral perfusion and cerebrospinal fluid convection, present observation presents a mechanism explaining earlier observations of impaired glymphatic clearance associated with AD in humans. |
| format |
article |
| author |
Timo Tuovinen Janne Kananen Zalan Rajna Johannes Lieslehto Vesa Korhonen Riikka Rytty Heli Mattila Niko Huotari Lauri Raitamaa Heta Helakari Ahmed Abou Elseoud Johanna Krüger Pierre LeVan Osmo Tervonen Juergen Hennig Anne M. Remes Maiken Nedergaard Vesa Kiviniemi |
| author_facet |
Timo Tuovinen Janne Kananen Zalan Rajna Johannes Lieslehto Vesa Korhonen Riikka Rytty Heli Mattila Niko Huotari Lauri Raitamaa Heta Helakari Ahmed Abou Elseoud Johanna Krüger Pierre LeVan Osmo Tervonen Juergen Hennig Anne M. Remes Maiken Nedergaard Vesa Kiviniemi |
| author_sort |
Timo Tuovinen |
| title |
The variability of functional MRI brain signal increases in Alzheimer's disease at cardiorespiratory frequencies |
| title_short |
The variability of functional MRI brain signal increases in Alzheimer's disease at cardiorespiratory frequencies |
| title_full |
The variability of functional MRI brain signal increases in Alzheimer's disease at cardiorespiratory frequencies |
| title_fullStr |
The variability of functional MRI brain signal increases in Alzheimer's disease at cardiorespiratory frequencies |
| title_full_unstemmed |
The variability of functional MRI brain signal increases in Alzheimer's disease at cardiorespiratory frequencies |
| title_sort |
variability of functional mri brain signal increases in alzheimer's disease at cardiorespiratory frequencies |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/caee84f1ec8b4f068b3915608e8cac85 |
| work_keys_str_mv |
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