SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition

SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition

Geminin-Cdt1 plays essential roles in the regulation of DNA replication. Here the authors reveal that the CULLIN3 E3 ubiquitin ligase adaptor protein SPOP prevents DNA replication over-firing and genome instability by affecting Geminin ubiquitination.

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Autores principales: Jian Ma, Qing Shi, Gaofeng Cui, Haoyue Sheng, Maria Victoria Botuyan, Yingke Zhou, Yuqian Yan, Yundong He, Liguo Wang, Yuzhuo Wang, Georges Mer, Dingwei Ye, Chenji Wang, Haojie Huang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/caf1ac2187f84e9cb816d00c2bdee890
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spelling oai:doaj.org-article:caf1ac2187f84e9cb816d00c2bdee8902021-12-02T18:51:09ZSPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition10.1038/s41467-021-26049-62041-1723https://doaj.org/article/caf1ac2187f84e9cb816d00c2bdee8902021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26049-6https://doaj.org/toc/2041-1723Geminin-Cdt1 plays essential roles in the regulation of DNA replication. Here the authors reveal that the CULLIN3 E3 ubiquitin ligase adaptor protein SPOP prevents DNA replication over-firing and genome instability by affecting Geminin ubiquitination.Jian MaQing ShiGaofeng CuiHaoyue ShengMaria Victoria BotuyanYingke ZhouYuqian YanYundong HeLiguo WangYuzhuo WangGeorges MerDingwei YeChenji WangHaojie HuangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jian Ma
Qing Shi
Gaofeng Cui
Haoyue Sheng
Maria Victoria Botuyan
Yingke Zhou
Yuqian Yan
Yundong He
Liguo Wang
Yuzhuo Wang
Georges Mer
Dingwei Ye
Chenji Wang
Haojie Huang
SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition
description Geminin-Cdt1 plays essential roles in the regulation of DNA replication. Here the authors reveal that the CULLIN3 E3 ubiquitin ligase adaptor protein SPOP prevents DNA replication over-firing and genome instability by affecting Geminin ubiquitination.
format article
author Jian Ma
Qing Shi
Gaofeng Cui
Haoyue Sheng
Maria Victoria Botuyan
Yingke Zhou
Yuqian Yan
Yundong He
Liguo Wang
Yuzhuo Wang
Georges Mer
Dingwei Ye
Chenji Wang
Haojie Huang
author_facet Jian Ma
Qing Shi
Gaofeng Cui
Haoyue Sheng
Maria Victoria Botuyan
Yingke Zhou
Yuqian Yan
Yundong He
Liguo Wang
Yuzhuo Wang
Georges Mer
Dingwei Ye
Chenji Wang
Haojie Huang
author_sort Jian Ma
title SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition
title_short SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition
title_full SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition
title_fullStr SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition
title_full_unstemmed SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition
title_sort spop mutation induces replication over-firing by impairing geminin ubiquitination and triggers replication catastrophe upon atr inhibition
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/caf1ac2187f84e9cb816d00c2bdee890
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