Genetic polymorphisms as prognostic factors for recurrent kidney stones: A systematic review and meta-analysis.

Genetic polymorphisms have been suggested as risk factors affecting the occurrence and recurrence of kidney stones, although findings regarding the latter remain inconclusive. We performed this systematic review and meta-analysis to clarify the associations between genetic polymorphisms and recurren...

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Autores principales:	Widi Atmoko, Putu Angga Risky Raharja, Ponco Birowo, Agus Rizal Ardy Hariandy Hamid, Akmal Taher, Nur Rasyid
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/caf1d086b5fd4c8fbe11421c314176fe
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spelling	oai:doaj.org-article:caf1d086b5fd4c8fbe11421c314176fe2021-11-25T06:19:17ZGenetic polymorphisms as prognostic factors for recurrent kidney stones: A systematic review and meta-analysis.1932-620310.1371/journal.pone.0251235https://doaj.org/article/caf1d086b5fd4c8fbe11421c314176fe2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251235https://doaj.org/toc/1932-6203Genetic polymorphisms have been suggested as risk factors affecting the occurrence and recurrence of kidney stones, although findings regarding the latter remain inconclusive. We performed this systematic review and meta-analysis to clarify the associations between genetic polymorphisms and recurrent kidney stones. PubMed, SCOPUS, EMBASE, and Cochrane Library databases were searched through May 28th, 2020 to identify eligible studies. The Quality in prognostic studies (QUIPS) tool was used to evaluate bias risk. Allelic frequencies and different inheritance models were assessed. All analyses were performed using Review manager 5.4. A total of 14 studies were included for meta-analysis, assessing urokinase (ApaL1) and vitamin D receptor (VDR) (ApaI, BsmI, FokI, and TaqI) gene polymorphisms. The ApaLI polymorphism demonstrated protective association in the recessive model [odds ratio (OR) 0.45, P < 0.01] albeit higher risk among Caucasians in the heterozygous model (OR 16.03, P < 0.01). The VDR-ApaI polymorphism showed protective association in the dominant model (OR 0.60, P < 0.01). Among Asians, the VDR-FokI polymorphism recessive model showed significant positive association (OR 1.70, P < 0.01) and the VDR-TaqI polymorphism heterozygous model exhibited protective association (OR 0.72, P < 0.01). The VDR-BsmI polymorphism was not significantly associated with recurrent kidney stones in any model. Urokinase-ApaLI (recessive model), VDR-ApaI (dominant model), and VDR-TaqI (heterozygous model) polymorphisms were associated with decreased recurrent kidney stone risk whereas urokinase-ApaLI (heterozygous model) and VDR-FokI polymorphisms were associated with increased risk among Caucasians and Asians, respectively. These findings will assist in identifying individuals at risk of kidney stone recurrence.Widi AtmokoPutu Angga Risky RaharjaPonco BirowoAgus Rizal Ardy Hariandy HamidAkmal TaherNur RasyidPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251235 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Widi Atmoko Putu Angga Risky Raharja Ponco Birowo Agus Rizal Ardy Hariandy Hamid Akmal Taher Nur Rasyid Genetic polymorphisms as prognostic factors for recurrent kidney stones: A systematic review and meta-analysis.
description	Genetic polymorphisms have been suggested as risk factors affecting the occurrence and recurrence of kidney stones, although findings regarding the latter remain inconclusive. We performed this systematic review and meta-analysis to clarify the associations between genetic polymorphisms and recurrent kidney stones. PubMed, SCOPUS, EMBASE, and Cochrane Library databases were searched through May 28th, 2020 to identify eligible studies. The Quality in prognostic studies (QUIPS) tool was used to evaluate bias risk. Allelic frequencies and different inheritance models were assessed. All analyses were performed using Review manager 5.4. A total of 14 studies were included for meta-analysis, assessing urokinase (ApaL1) and vitamin D receptor (VDR) (ApaI, BsmI, FokI, and TaqI) gene polymorphisms. The ApaLI polymorphism demonstrated protective association in the recessive model [odds ratio (OR) 0.45, P < 0.01] albeit higher risk among Caucasians in the heterozygous model (OR 16.03, P < 0.01). The VDR-ApaI polymorphism showed protective association in the dominant model (OR 0.60, P < 0.01). Among Asians, the VDR-FokI polymorphism recessive model showed significant positive association (OR 1.70, P < 0.01) and the VDR-TaqI polymorphism heterozygous model exhibited protective association (OR 0.72, P < 0.01). The VDR-BsmI polymorphism was not significantly associated with recurrent kidney stones in any model. Urokinase-ApaLI (recessive model), VDR-ApaI (dominant model), and VDR-TaqI (heterozygous model) polymorphisms were associated with decreased recurrent kidney stone risk whereas urokinase-ApaLI (heterozygous model) and VDR-FokI polymorphisms were associated with increased risk among Caucasians and Asians, respectively. These findings will assist in identifying individuals at risk of kidney stone recurrence.
format	article
author	Widi Atmoko Putu Angga Risky Raharja Ponco Birowo Agus Rizal Ardy Hariandy Hamid Akmal Taher Nur Rasyid
author_facet	Widi Atmoko Putu Angga Risky Raharja Ponco Birowo Agus Rizal Ardy Hariandy Hamid Akmal Taher Nur Rasyid
author_sort	Widi Atmoko
title	Genetic polymorphisms as prognostic factors for recurrent kidney stones: A systematic review and meta-analysis.
title_short	Genetic polymorphisms as prognostic factors for recurrent kidney stones: A systematic review and meta-analysis.
title_full	Genetic polymorphisms as prognostic factors for recurrent kidney stones: A systematic review and meta-analysis.
title_fullStr	Genetic polymorphisms as prognostic factors for recurrent kidney stones: A systematic review and meta-analysis.
title_full_unstemmed	Genetic polymorphisms as prognostic factors for recurrent kidney stones: A systematic review and meta-analysis.
title_sort	genetic polymorphisms as prognostic factors for recurrent kidney stones: a systematic review and meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/caf1d086b5fd4c8fbe11421c314176fe
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Genetic polymorphisms as prognostic factors for recurrent kidney stones: A systematic review and meta-analysis.

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