Using regulatory variants to detect gene–gene interactions identifies networks of genes linked to cell immortalisation

For most human genes nearby regulatory variants explain only a small proportion of their expression variation between individuals. Here the authors show how the impact of a gene’s set of nearby regulatory variant is often linked to the expression levels of distal genes, providing insights into gene...

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Autores principales:	D. Wragg, Q. Liu, Z. Lin, V. Riggio, C. A. Pugh, A. J. Beveridge, H. Brown, D. A. Hume, S. E. Harris, I. J. Deary, A. Tenesa, J. G. D. Prendergast
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/caf3c6c3130d4e6b811575159199dd1a
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spelling	oai:doaj.org-article:caf3c6c3130d4e6b811575159199dd1a2021-12-02T17:31:25ZUsing regulatory variants to detect gene–gene interactions identifies networks of genes linked to cell immortalisation10.1038/s41467-019-13762-62041-1723https://doaj.org/article/caf3c6c3130d4e6b811575159199dd1a2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13762-6https://doaj.org/toc/2041-1723For most human genes nearby regulatory variants explain only a small proportion of their expression variation between individuals. Here the authors show how the impact of a gene’s set of nearby regulatory variant is often linked to the expression levels of distal genes, providing insights into gene networks.D. WraggQ. LiuZ. LinV. RiggioC. A. PughA. J. BeveridgeH. BrownD. A. HumeS. E. HarrisI. J. DearyA. TenesaJ. G. D. PrendergastNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q D. Wragg Q. Liu Z. Lin V. Riggio C. A. Pugh A. J. Beveridge H. Brown D. A. Hume S. E. Harris I. J. Deary A. Tenesa J. G. D. Prendergast Using regulatory variants to detect gene–gene interactions identifies networks of genes linked to cell immortalisation
description	For most human genes nearby regulatory variants explain only a small proportion of their expression variation between individuals. Here the authors show how the impact of a gene’s set of nearby regulatory variant is often linked to the expression levels of distal genes, providing insights into gene networks.
format	article
author	D. Wragg Q. Liu Z. Lin V. Riggio C. A. Pugh A. J. Beveridge H. Brown D. A. Hume S. E. Harris I. J. Deary A. Tenesa J. G. D. Prendergast
author_facet	D. Wragg Q. Liu Z. Lin V. Riggio C. A. Pugh A. J. Beveridge H. Brown D. A. Hume S. E. Harris I. J. Deary A. Tenesa J. G. D. Prendergast
author_sort	D. Wragg
title	Using regulatory variants to detect gene–gene interactions identifies networks of genes linked to cell immortalisation
title_short	Using regulatory variants to detect gene–gene interactions identifies networks of genes linked to cell immortalisation
title_full	Using regulatory variants to detect gene–gene interactions identifies networks of genes linked to cell immortalisation
title_fullStr	Using regulatory variants to detect gene–gene interactions identifies networks of genes linked to cell immortalisation
title_full_unstemmed	Using regulatory variants to detect gene–gene interactions identifies networks of genes linked to cell immortalisation
title_sort	using regulatory variants to detect gene–gene interactions identifies networks of genes linked to cell immortalisation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/caf3c6c3130d4e6b811575159199dd1a
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Using regulatory variants to detect gene–gene interactions identifies networks of genes linked to cell immortalisation

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