Using regulatory variants to detect gene–gene interactions identifies networks of genes linked to cell immortalisation

Using regulatory variants to detect gene–gene interactions identifies networks of genes linked to cell immortalisation

For most human genes nearby regulatory variants explain only a small proportion of their expression variation between individuals. Here the authors show how the impact of a gene’s set of nearby regulatory variant is often linked to the expression levels of distal genes, providing insights into gene...

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Autores principales: D. Wragg, Q. Liu, Z. Lin, V. Riggio, C. A. Pugh, A. J. Beveridge, H. Brown, D. A. Hume, S. E. Harris, I. J. Deary, A. Tenesa, J. G. D. Prendergast
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/caf3c6c3130d4e6b811575159199dd1a
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