GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation

GLP-1 receptor signalling promotes β-cell glucose metabolism via mTOR-dependent HIF-1α activation

Abstract Glucagon-like peptide-1 (GLP-1) promotes insulin secretion from pancreatic β-cells in a glucose dependent manner. Several pathways mediate this action by rapid, kinase phosphorylation-dependent, but gene expression-independent mechanisms. Since GLP-1-induced insulin secretion requires gluco...

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Main Authors: Rodrigo Carlessi, Younan Chen, Jordan Rowlands, Vinicius F. Cruzat, Kevin N. Keane, Lauren Egan, Cyril Mamotte, Rebecca Stokes, Jenny E. Gunton, Paulo Ivo Homem de Bittencourt, Philip Newsholme
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/caf5cdca187a473db8fc37928e03d4c9
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https://doaj.org/article/caf5cdca187a473db8fc37928e03d4c9

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