An engineered CRISPR-Cas12a variant and DNA-RNA hybrid guides enable robust and rapid COVID-19 testing
As the COVID-19 pandemic continues, variants of the virus are emerging. Here the authors present a diagnostic assay that can detect wildtype and known variants using engineered Cas12a.
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Nature Portfolio
2021
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oai:doaj.org-article:caf7de7ec01a4742a1eed676b48f380b2021-12-02T11:39:46ZAn engineered CRISPR-Cas12a variant and DNA-RNA hybrid guides enable robust and rapid COVID-19 testing10.1038/s41467-021-21996-62041-1723https://doaj.org/article/caf7de7ec01a4742a1eed676b48f380b2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21996-6https://doaj.org/toc/2041-1723As the COVID-19 pandemic continues, variants of the virus are emerging. Here the authors present a diagnostic assay that can detect wildtype and known variants using engineered Cas12a.Kean Hean OoiMengying Mandy LiuJie Wen Douglas TaySeok Yee TeoPornchai KaewsapsakShengyang JinChun Kiat LeeJingwen HouSebastian Maurer-StrohWeisi LinBenedict YanGabriel YanYong-Gui GaoMeng How TanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-23 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Kean Hean Ooi Mengying Mandy Liu Jie Wen Douglas Tay Seok Yee Teo Pornchai Kaewsapsak Shengyang Jin Chun Kiat Lee Jingwen Hou Sebastian Maurer-Stroh Weisi Lin Benedict Yan Gabriel Yan Yong-Gui Gao Meng How Tan An engineered CRISPR-Cas12a variant and DNA-RNA hybrid guides enable robust and rapid COVID-19 testing |
| description |
As the COVID-19 pandemic continues, variants of the virus are emerging. Here the authors present a diagnostic assay that can detect wildtype and known variants using engineered Cas12a. |
| format |
article |
| author |
Kean Hean Ooi Mengying Mandy Liu Jie Wen Douglas Tay Seok Yee Teo Pornchai Kaewsapsak Shengyang Jin Chun Kiat Lee Jingwen Hou Sebastian Maurer-Stroh Weisi Lin Benedict Yan Gabriel Yan Yong-Gui Gao Meng How Tan |
| author_facet |
Kean Hean Ooi Mengying Mandy Liu Jie Wen Douglas Tay Seok Yee Teo Pornchai Kaewsapsak Shengyang Jin Chun Kiat Lee Jingwen Hou Sebastian Maurer-Stroh Weisi Lin Benedict Yan Gabriel Yan Yong-Gui Gao Meng How Tan |
| author_sort |
Kean Hean Ooi |
| title |
An engineered CRISPR-Cas12a variant and DNA-RNA hybrid guides enable robust and rapid COVID-19 testing |
| title_short |
An engineered CRISPR-Cas12a variant and DNA-RNA hybrid guides enable robust and rapid COVID-19 testing |
| title_full |
An engineered CRISPR-Cas12a variant and DNA-RNA hybrid guides enable robust and rapid COVID-19 testing |
| title_fullStr |
An engineered CRISPR-Cas12a variant and DNA-RNA hybrid guides enable robust and rapid COVID-19 testing |
| title_full_unstemmed |
An engineered CRISPR-Cas12a variant and DNA-RNA hybrid guides enable robust and rapid COVID-19 testing |
| title_sort |
engineered crispr-cas12a variant and dna-rna hybrid guides enable robust and rapid covid-19 testing |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/caf7de7ec01a4742a1eed676b48f380b |
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