Nanopore sequencing of brain-derived full-length circRNAs reveals circRNA-specific exon usage, intron retention and microexons

Short-read sequencing methods cannot delineate internal exon composition and alternative splicing events of long and multi-exon circular RNAs (circRNAs). Here the authors provide a global map of full-length circRNAs by long-read sequencing in human and mouse brain samples.

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Autores principales:	Karim Rahimi, Morten T. Venø, Daniel M. Dupont, Jørgen Kjems
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/caf8add5fb2e4f0f8efcdf021c9ce999
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spelling	oai:doaj.org-article:caf8add5fb2e4f0f8efcdf021c9ce9992021-12-02T15:07:56ZNanopore sequencing of brain-derived full-length circRNAs reveals circRNA-specific exon usage, intron retention and microexons10.1038/s41467-021-24975-z2041-1723https://doaj.org/article/caf8add5fb2e4f0f8efcdf021c9ce9992021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24975-zhttps://doaj.org/toc/2041-1723Short-read sequencing methods cannot delineate internal exon composition and alternative splicing events of long and multi-exon circular RNAs (circRNAs). Here the authors provide a global map of full-length circRNAs by long-read sequencing in human and mouse brain samples.Karim RahimiMorten T. VenøDaniel M. DupontJørgen KjemsNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Karim Rahimi Morten T. Venø Daniel M. Dupont Jørgen Kjems Nanopore sequencing of brain-derived full-length circRNAs reveals circRNA-specific exon usage, intron retention and microexons
description	Short-read sequencing methods cannot delineate internal exon composition and alternative splicing events of long and multi-exon circular RNAs (circRNAs). Here the authors provide a global map of full-length circRNAs by long-read sequencing in human and mouse brain samples.
format	article
author	Karim Rahimi Morten T. Venø Daniel M. Dupont Jørgen Kjems
author_facet	Karim Rahimi Morten T. Venø Daniel M. Dupont Jørgen Kjems
author_sort	Karim Rahimi
title	Nanopore sequencing of brain-derived full-length circRNAs reveals circRNA-specific exon usage, intron retention and microexons
title_short	Nanopore sequencing of brain-derived full-length circRNAs reveals circRNA-specific exon usage, intron retention and microexons
title_full	Nanopore sequencing of brain-derived full-length circRNAs reveals circRNA-specific exon usage, intron retention and microexons
title_fullStr	Nanopore sequencing of brain-derived full-length circRNAs reveals circRNA-specific exon usage, intron retention and microexons
title_full_unstemmed	Nanopore sequencing of brain-derived full-length circRNAs reveals circRNA-specific exon usage, intron retention and microexons
title_sort	nanopore sequencing of brain-derived full-length circrnas reveals circrna-specific exon usage, intron retention and microexons
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/caf8add5fb2e4f0f8efcdf021c9ce999
work_keys_str_mv	AT karimrahimi nanoporesequencingofbrainderivedfulllengthcircrnasrevealscircrnaspecificexonusageintronretentionandmicroexons AT mortentvenø nanoporesequencingofbrainderivedfulllengthcircrnasrevealscircrnaspecificexonusageintronretentionandmicroexons AT danielmdupont nanoporesequencingofbrainderivedfulllengthcircrnasrevealscircrnaspecificexonusageintronretentionandmicroexons AT jørgenkjems nanoporesequencingofbrainderivedfulllengthcircrnasrevealscircrnaspecificexonusageintronretentionandmicroexons
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Nanopore sequencing of brain-derived full-length circRNAs reveals circRNA-specific exon usage, intron retention and microexons

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