Classification of skin phenotypes caused by diabetes mellitus using complex scattering parameters in the millimeter-wave frequency range
Abstract The pathological skin phenotype caused by hyperglycemia is an important indicator for the progress of diabetes mellitus. An early detection of diabetes assures an early intervention to regulate the carbohydrate metabolism. In this publication a non-invasive detection principle based on the...
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Nature Portfolio
2017
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oai:doaj.org-article:cafac1b43c9943918457cbca25b696622021-12-02T11:40:34ZClassification of skin phenotypes caused by diabetes mellitus using complex scattering parameters in the millimeter-wave frequency range10.1038/s41598-017-06034-02045-2322https://doaj.org/article/cafac1b43c9943918457cbca25b696622017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06034-0https://doaj.org/toc/2045-2322Abstract The pathological skin phenotype caused by hyperglycemia is an important indicator for the progress of diabetes mellitus. An early detection of diabetes assures an early intervention to regulate the carbohydrate metabolism. In this publication a non-invasive detection principle based on the measurement of complex scattering parameters in the millimeter-wave frequency range is presented. The measurement principle provides evidence of the applicability for the identification of different glycemic states in animal models. The method proposed here can be used to predict diabetes status in animal models and is interesting for application on humans in view of safeness of millimeter-wave radiation. Furthermore the complex scattering parameters give important information about the anatomic varieties between the analyzed skin samples of the different mice strains. In contrast to other methods, our approach is less sensitive to skin variations between animals.Fabian DornufPedro Martín-MateosBlanca DuarteBernhard HilsOscar Elias Bonilla-ManriqueFernando LarcherPablo AcedoViktor KrozerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017) |
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Medicine R Science Q Fabian Dornuf Pedro Martín-Mateos Blanca Duarte Bernhard Hils Oscar Elias Bonilla-Manrique Fernando Larcher Pablo Acedo Viktor Krozer Classification of skin phenotypes caused by diabetes mellitus using complex scattering parameters in the millimeter-wave frequency range |
description |
Abstract The pathological skin phenotype caused by hyperglycemia is an important indicator for the progress of diabetes mellitus. An early detection of diabetes assures an early intervention to regulate the carbohydrate metabolism. In this publication a non-invasive detection principle based on the measurement of complex scattering parameters in the millimeter-wave frequency range is presented. The measurement principle provides evidence of the applicability for the identification of different glycemic states in animal models. The method proposed here can be used to predict diabetes status in animal models and is interesting for application on humans in view of safeness of millimeter-wave radiation. Furthermore the complex scattering parameters give important information about the anatomic varieties between the analyzed skin samples of the different mice strains. In contrast to other methods, our approach is less sensitive to skin variations between animals. |
format |
article |
author |
Fabian Dornuf Pedro Martín-Mateos Blanca Duarte Bernhard Hils Oscar Elias Bonilla-Manrique Fernando Larcher Pablo Acedo Viktor Krozer |
author_facet |
Fabian Dornuf Pedro Martín-Mateos Blanca Duarte Bernhard Hils Oscar Elias Bonilla-Manrique Fernando Larcher Pablo Acedo Viktor Krozer |
author_sort |
Fabian Dornuf |
title |
Classification of skin phenotypes caused by diabetes mellitus using complex scattering parameters in the millimeter-wave frequency range |
title_short |
Classification of skin phenotypes caused by diabetes mellitus using complex scattering parameters in the millimeter-wave frequency range |
title_full |
Classification of skin phenotypes caused by diabetes mellitus using complex scattering parameters in the millimeter-wave frequency range |
title_fullStr |
Classification of skin phenotypes caused by diabetes mellitus using complex scattering parameters in the millimeter-wave frequency range |
title_full_unstemmed |
Classification of skin phenotypes caused by diabetes mellitus using complex scattering parameters in the millimeter-wave frequency range |
title_sort |
classification of skin phenotypes caused by diabetes mellitus using complex scattering parameters in the millimeter-wave frequency range |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/cafac1b43c9943918457cbca25b69662 |
work_keys_str_mv |
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1718395607228350464 |