Cdt1 stabilizes an open MCM ring for helicase loading

The loading and activation of the Mcm2-7 replicative helicase couples cell cycle progression to DNA replication. Here the authors use X-ray crystallography and single-particle electron microscopy to demonstrate how Ctd1 functions to promote MCM loading onto DNA.

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Autores principales:	Jordi Frigola, Jun He, Kerstin Kinkelin, Valerie E. Pye, Ludovic Renault, Max E. Douglas, Dirk Remus, Peter Cherepanov, Alessandro Costa, John F. X. Diffley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/cb03dbf473dc4d6197f8ab99b9768f4a
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spelling	oai:doaj.org-article:cb03dbf473dc4d6197f8ab99b9768f4a2021-12-02T15:38:32ZCdt1 stabilizes an open MCM ring for helicase loading10.1038/ncomms157202041-1723https://doaj.org/article/cb03dbf473dc4d6197f8ab99b9768f4a2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15720https://doaj.org/toc/2041-1723The loading and activation of the Mcm2-7 replicative helicase couples cell cycle progression to DNA replication. Here the authors use X-ray crystallography and single-particle electron microscopy to demonstrate how Ctd1 functions to promote MCM loading onto DNA.Jordi FrigolaJun HeKerstin KinkelinValerie E. PyeLudovic RenaultMax E. DouglasDirk RemusPeter CherepanovAlessandro CostaJohn F. X. DiffleyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jordi Frigola Jun He Kerstin Kinkelin Valerie E. Pye Ludovic Renault Max E. Douglas Dirk Remus Peter Cherepanov Alessandro Costa John F. X. Diffley Cdt1 stabilizes an open MCM ring for helicase loading
description	The loading and activation of the Mcm2-7 replicative helicase couples cell cycle progression to DNA replication. Here the authors use X-ray crystallography and single-particle electron microscopy to demonstrate how Ctd1 functions to promote MCM loading onto DNA.
format	article
author	Jordi Frigola Jun He Kerstin Kinkelin Valerie E. Pye Ludovic Renault Max E. Douglas Dirk Remus Peter Cherepanov Alessandro Costa John F. X. Diffley
author_facet	Jordi Frigola Jun He Kerstin Kinkelin Valerie E. Pye Ludovic Renault Max E. Douglas Dirk Remus Peter Cherepanov Alessandro Costa John F. X. Diffley
author_sort	Jordi Frigola
title	Cdt1 stabilizes an open MCM ring for helicase loading
title_short	Cdt1 stabilizes an open MCM ring for helicase loading
title_full	Cdt1 stabilizes an open MCM ring for helicase loading
title_fullStr	Cdt1 stabilizes an open MCM ring for helicase loading
title_full_unstemmed	Cdt1 stabilizes an open MCM ring for helicase loading
title_sort	cdt1 stabilizes an open mcm ring for helicase loading
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/cb03dbf473dc4d6197f8ab99b9768f4a
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Cdt1 stabilizes an open MCM ring for helicase loading

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