Multimodal Chorioretinal Imaging in Erdheim-Chester Disease

Riccardo Sacconi,1,* Corrado Campochiaro,2,* Alessandro Rabiolo,1,* Alessandro Marchese,1 Alessandro Tomelleri,2 Livia Tomasso,1 Maria Vittoria Cicinelli,1 Lea Querques,1 Francesco Bandello,1 Lorenzo Dagna,2,* Giuseppe Querques1,* 1Department of Ophthalmology, University Vita-Salute, IRCCS San Raffa...

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Autores principales:	Sacconi R, Campochiaro C, Rabiolo A, Marchese A, Tomelleri A, Tomasso L, Cicinelli MV, Querques L, Bandello F, Dagna L, Querques G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	erdheim-chester disease histiocytosis fluorescein angiography indocyanine green angiography optical coherence tomography. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/cb069311afc440a68755968ce68d7217
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spelling	oai:doaj.org-article:cb069311afc440a68755968ce68d72172021-12-02T10:00:20ZMultimodal Chorioretinal Imaging in Erdheim-Chester Disease1177-5483https://doaj.org/article/cb069311afc440a68755968ce68d72172020-02-01T00:00:00Zhttps://www.dovepress.com/multimodal-chorioretinal-imaging-in-erdheim-chester-disease-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Riccardo Sacconi,1,* Corrado Campochiaro,2,* Alessandro Rabiolo,1,* Alessandro Marchese,1 Alessandro Tomelleri,2 Livia Tomasso,1 Maria Vittoria Cicinelli,1 Lea Querques,1 Francesco Bandello,1 Lorenzo Dagna,2,* Giuseppe Querques1,* 1Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele Scientific Institute, Milan, Italy; 2Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy*These authors contributed equally to this workCorrespondence: Giuseppe QuerquesDepartment of Ophthalmology, University Vita-Salute, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan 20132, ItalyTel +39 0226432648Fax +39 0226433643Email giuseppe.querques@hotmail.itPurpose: To analyze the subclinical intraocular involvement using multimodal imaging approach in patients affected by Erdheim-Chester disease (ECD) without ocular symptoms.Patients and Methods: In this prospective cross-sectional study, 18 eyes of 9 consecutive patients with ECD were enrolled. Each patient underwent comprehensive ocular examination and extensive multimodal chorioretinal imaging.Results: None of the patients presented any evidence of chorioretinal localization of disease using multimodal imaging. One patient exhibited a choroidal nevus complicated by active polypoidal choroidal neovascularization. Subretinal hyperreflective material was seen in three eyes, mainly resembling acquired vitelliform lesion. One patient had an isolated intraretinal hemorrhage. Most patients exhibited peripheral vascular abnormalities (ie, microaneurysms, peripheral vascular leakage). Fundus autofluorescence showed faint hyperautofluorescence in eleven eyes.Conclusion: Intraocular involvement is an extremely rare event of an extremely rare disease. In patients affected by ECD without ocular symptoms, advance multimodal imaging examinations did not show signs of subclinical chorioretinal involvement related to the disease.Keywords: Erdheim-Chester disease, histiocytosis, fluorescein angiography, indocyanine green angiography, optical coherence tomographySacconi RCampochiaro CRabiolo AMarchese ATomelleri ATomasso LCicinelli MVQuerques LBandello FDagna LQuerques GDove Medical Pressarticleerdheim-chester diseasehistiocytosisfluorescein angiographyindocyanine green angiographyoptical coherence tomography.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 581-588 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	erdheim-chester disease histiocytosis fluorescein angiography indocyanine green angiography optical coherence tomography. Ophthalmology RE1-994
spellingShingle	erdheim-chester disease histiocytosis fluorescein angiography indocyanine green angiography optical coherence tomography. Ophthalmology RE1-994 Sacconi R Campochiaro C Rabiolo A Marchese A Tomelleri A Tomasso L Cicinelli MV Querques L Bandello F Dagna L Querques G Multimodal Chorioretinal Imaging in Erdheim-Chester Disease
description	Riccardo Sacconi,1,* Corrado Campochiaro,2,* Alessandro Rabiolo,1,* Alessandro Marchese,1 Alessandro Tomelleri,2 Livia Tomasso,1 Maria Vittoria Cicinelli,1 Lea Querques,1 Francesco Bandello,1 Lorenzo Dagna,2,* Giuseppe Querques1,* 1Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele Scientific Institute, Milan, Italy; 2Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy*These authors contributed equally to this workCorrespondence: Giuseppe QuerquesDepartment of Ophthalmology, University Vita-Salute, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan 20132, ItalyTel +39 0226432648Fax +39 0226433643Email giuseppe.querques@hotmail.itPurpose: To analyze the subclinical intraocular involvement using multimodal imaging approach in patients affected by Erdheim-Chester disease (ECD) without ocular symptoms.Patients and Methods: In this prospective cross-sectional study, 18 eyes of 9 consecutive patients with ECD were enrolled. Each patient underwent comprehensive ocular examination and extensive multimodal chorioretinal imaging.Results: None of the patients presented any evidence of chorioretinal localization of disease using multimodal imaging. One patient exhibited a choroidal nevus complicated by active polypoidal choroidal neovascularization. Subretinal hyperreflective material was seen in three eyes, mainly resembling acquired vitelliform lesion. One patient had an isolated intraretinal hemorrhage. Most patients exhibited peripheral vascular abnormalities (ie, microaneurysms, peripheral vascular leakage). Fundus autofluorescence showed faint hyperautofluorescence in eleven eyes.Conclusion: Intraocular involvement is an extremely rare event of an extremely rare disease. In patients affected by ECD without ocular symptoms, advance multimodal imaging examinations did not show signs of subclinical chorioretinal involvement related to the disease.Keywords: Erdheim-Chester disease, histiocytosis, fluorescein angiography, indocyanine green angiography, optical coherence tomography
format	article
author	Sacconi R Campochiaro C Rabiolo A Marchese A Tomelleri A Tomasso L Cicinelli MV Querques L Bandello F Dagna L Querques G
author_facet	Sacconi R Campochiaro C Rabiolo A Marchese A Tomelleri A Tomasso L Cicinelli MV Querques L Bandello F Dagna L Querques G
author_sort	Sacconi R
title	Multimodal Chorioretinal Imaging in Erdheim-Chester Disease
title_short	Multimodal Chorioretinal Imaging in Erdheim-Chester Disease
title_full	Multimodal Chorioretinal Imaging in Erdheim-Chester Disease
title_fullStr	Multimodal Chorioretinal Imaging in Erdheim-Chester Disease
title_full_unstemmed	Multimodal Chorioretinal Imaging in Erdheim-Chester Disease
title_sort	multimodal chorioretinal imaging in erdheim-chester disease
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/cb069311afc440a68755968ce68d7217
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Multimodal Chorioretinal Imaging in Erdheim-Chester Disease

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