Comparative effects of magnetic and water-based hyperthermia treatments on human osteosarcoma cells

Dumitru-Daniel Herea,1,* Camelia Danceanu,1,2,* Ecaterina Radu,1,2,* Luminita Labusca,1,3,* Nicoleta Lupu,1,* Horia Chiriac1,* 1MDM Department, National Institute of Research and Development for Technical Physics, Iasi, Romania; 2University “Al I Cuza,” University of Iasi, Iasi,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Herea D, Danceanu C, Radu E, Labusca L, Lupu N, Chiriac H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	magnetic hyperthermia water-based hyperthermia magnetic nanoparticles cancer cells Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/cb07df224be04e52b3e001a43fc01f78
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:cb07df224be04e52b3e001a43fc01f78
record_format	dspace
spelling	oai:doaj.org-article:cb07df224be04e52b3e001a43fc01f782021-12-02T02:52:42ZComparative effects of magnetic and water-based hyperthermia treatments on human osteosarcoma cells1178-2013https://doaj.org/article/cb07df224be04e52b3e001a43fc01f782018-09-01T00:00:00Zhttps://www.dovepress.com/comparative-effects-of-magnetic-and-water-based-hyperthermia-treatment-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Dumitru-Daniel Herea,1,* Camelia Danceanu,1,2,* Ecaterina Radu,1,2,* Luminita Labusca,1,3,* Nicoleta Lupu,1,* Horia Chiriac1,* 1MDM Department, National Institute of Research and Development for Technical Physics, Iasi, Romania; 2University “Al I Cuza,” University of Iasi, Iasi, Romania; 3Systems Biomedical Informatics and Modeling (SBIM), Frankfurt, Germany *These authors contributed equally to this work Introduction: Hyperthermia (HT) based on magnetic nanoparticles (MNPs) represents a promising approach to induce the apoptosis/necrosis of tumor cells through the heat generated by MNPs submitted to alternating magnetic fields. However, the effects of temperature distribution on the cancer cells’ viability as well as heat resistance of various tumor cell types warrant further investigation. Methods: In this work, the effects induced by magnetic hyperthermia (MHT) and conventional water-based hyperthermia (WHT) on the viability of human osteosarcoma cells at different temperatures (37°C–47°C) was comparatively investigated. Fe-Cr-Nb-B magnetic nanoparticles were submitted either to alternating magnetic fields or to infrared radiation generated by a water-heated incubator. Results: In terms of cell viability, significant differences could be observed after applying the two HT treatment methods. At about equal equilibrium temperatures, MHT was on average 16% more efficient in inducing cytotoxicity effects compared to WHT, as assessed by MTT cytotoxicity assay. Conclusion: We propose the phenomena can be explained by the significantly higher cytotoxic effects initiated during MHT treatment in the vicinity of the heat-generating MNPs compared to the effects triggered by the homogeneously distributed temperature during WHT. These in vitro results confirm other previous findings regarding the superior efficiency of MHT over WHT and explain the cytotoxicity differences observed between the two antitumor HT methods. Keywords: magnetic hyperthermia, water-based hyperthermia, magnetic nanoparticles, cancer cellsHerea DDanceanu CRadu ELabusca LLupu NChiriac HDove Medical Pressarticlemagnetic hyperthermiawater-based hyperthermiamagnetic nanoparticlescancer cellsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 5743-5751 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnetic hyperthermia water-based hyperthermia magnetic nanoparticles cancer cells Medicine (General) R5-920
spellingShingle	magnetic hyperthermia water-based hyperthermia magnetic nanoparticles cancer cells Medicine (General) R5-920 Herea D Danceanu C Radu E Labusca L Lupu N Chiriac H Comparative effects of magnetic and water-based hyperthermia treatments on human osteosarcoma cells
description	Dumitru-Daniel Herea,1,* Camelia Danceanu,1,2,* Ecaterina Radu,1,2,* Luminita Labusca,1,3,* Nicoleta Lupu,1,* Horia Chiriac1,* 1MDM Department, National Institute of Research and Development for Technical Physics, Iasi, Romania; 2University “Al I Cuza,” University of Iasi, Iasi, Romania; 3Systems Biomedical Informatics and Modeling (SBIM), Frankfurt, Germany *These authors contributed equally to this work Introduction: Hyperthermia (HT) based on magnetic nanoparticles (MNPs) represents a promising approach to induce the apoptosis/necrosis of tumor cells through the heat generated by MNPs submitted to alternating magnetic fields. However, the effects of temperature distribution on the cancer cells’ viability as well as heat resistance of various tumor cell types warrant further investigation. Methods: In this work, the effects induced by magnetic hyperthermia (MHT) and conventional water-based hyperthermia (WHT) on the viability of human osteosarcoma cells at different temperatures (37°C–47°C) was comparatively investigated. Fe-Cr-Nb-B magnetic nanoparticles were submitted either to alternating magnetic fields or to infrared radiation generated by a water-heated incubator. Results: In terms of cell viability, significant differences could be observed after applying the two HT treatment methods. At about equal equilibrium temperatures, MHT was on average 16% more efficient in inducing cytotoxicity effects compared to WHT, as assessed by MTT cytotoxicity assay. Conclusion: We propose the phenomena can be explained by the significantly higher cytotoxic effects initiated during MHT treatment in the vicinity of the heat-generating MNPs compared to the effects triggered by the homogeneously distributed temperature during WHT. These in vitro results confirm other previous findings regarding the superior efficiency of MHT over WHT and explain the cytotoxicity differences observed between the two antitumor HT methods. Keywords: magnetic hyperthermia, water-based hyperthermia, magnetic nanoparticles, cancer cells
format	article
author	Herea D Danceanu C Radu E Labusca L Lupu N Chiriac H
author_facet	Herea D Danceanu C Radu E Labusca L Lupu N Chiriac H
author_sort	Herea D
title	Comparative effects of magnetic and water-based hyperthermia treatments on human osteosarcoma cells
title_short	Comparative effects of magnetic and water-based hyperthermia treatments on human osteosarcoma cells
title_full	Comparative effects of magnetic and water-based hyperthermia treatments on human osteosarcoma cells
title_fullStr	Comparative effects of magnetic and water-based hyperthermia treatments on human osteosarcoma cells
title_full_unstemmed	Comparative effects of magnetic and water-based hyperthermia treatments on human osteosarcoma cells
title_sort	comparative effects of magnetic and water-based hyperthermia treatments on human osteosarcoma cells
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/cb07df224be04e52b3e001a43fc01f78
work_keys_str_mv	AT heread comparativeeffectsofmagneticandwaterbasedhyperthermiatreatmentsonhumanosteosarcomacells AT danceanuc comparativeeffectsofmagneticandwaterbasedhyperthermiatreatmentsonhumanosteosarcomacells AT radue comparativeeffectsofmagneticandwaterbasedhyperthermiatreatmentsonhumanosteosarcomacells AT labuscal comparativeeffectsofmagneticandwaterbasedhyperthermiatreatmentsonhumanosteosarcomacells AT lupun comparativeeffectsofmagneticandwaterbasedhyperthermiatreatmentsonhumanosteosarcomacells AT chiriach comparativeeffectsofmagneticandwaterbasedhyperthermiatreatmentsonhumanosteosarcomacells
_version_	1718402125659111424

Comparative effects of magnetic and water-based hyperthermia treatments on human osteosarcoma cells

Ejemplares similares